Issue Date | Title | Involved Person(s) |
10-Jun-2019 | Approaching target selectivity by de novo drug design | Fischer, Thomas; Gazzola, Silvia; Riedl, Rainer |
14-Sep-2020 | Challenges with matrix metalloproteinase inhibition and future drug discovery avenues | Fischer, Thomas; Riedl, Rainer |
2017 | Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017) | Fischer, Thomas; Riedl, Rainer |
2017 | Cover profile : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor | Fischer, Thomas; Riedl, Rainer |
5-Feb-2019 | Design and structural evolution of matrix metalloproteinase inhibitors | Fischer, Thomas; Senn, Nicole; Riedl, Rainer |
2012 | Design, synthesis and biological testing of novel MMP-inhibitors | Fischer, Thomas; Riedl, Rainer |
2017 | Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor | Fischer, Thomas; Riedl, Rainer |
16-Sep-2010 | Fragment based scaffold hopping in drug discovery | Riedl, Rainer; Fischer, Thomas |
2019 | High consistency of structure-based design and x-ray crystallography : design, synthesis, kinetic evaluation and crystallographic binding mode determination of biphenyl-N-acyl-β-D-glucopyranosylamines as glycogen phosphorylase inhibitors | Fischer, Thomas; Koulas, Symeon M.; Tsagkarakou, Anastasia S.; Kyriakis, Efthimios; Stravodimos, George A., et al |
2019 | Inhibitory antibodies designed for matrix metalloproteinase modulation | Fischer, Thomas; Riedl, Rainer |
2016 | Molecular recognition of the catalytic zinc(II) ion in MMP-13 : structure-based evolution of an allosteric inhibitor to dual binding mode inhibitors with improved lipophilic ligand efficiencies | Fischer, Thomas; Riedl, Rainer |
23-Jan-2021 | New perspectives in oral peptide delivery | Zizzari, Alessandra Tania; Pliatsika, Dimanthi; Gall, Flavio; Fischer, Thomas; Riedl, Rainer |
Feb-2022 | Paracelsus' legacy in the faunal realm : drugs deriving from animal toxins | Fischer, Thomas; Riedl, Rainer |
2013 | Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors | Fischer, Thomas; Riedl, Rainer |
2012 | Structure based design and synthesis of novel MMP inhibitors | Riedl, Rainer; Fischer, Thomas |
Sep-2011 | Structure based design and synthesis of novel MMP inhibitors | Riedl, Rainer; Fischer, Thomas; Züger, Patrik; Brand, Michael |
2017 | Targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor | Fischer, Thomas; Riedl, Rainer |