| Publication type: | Conference poster |
| Type of review: | Not specified |
| Title: | Shape-based assessment of intracranial aneurysm disease status |
| Authors: | Juchler, Norman Schilling, Sabine Vartan, Kurtcuoglu Hirsch, Sven |
| Conference details: | ZNZ Symposium 2016, Zurich, 15. September 2016 |
| Issue Date: | 15-Sep-2016 |
| Language: | English |
| Subjects: | Shape-based risk assessment; Intracranial aneurysms |
| Subject (DDC): | 616: Internal medicine and diseases |
| Abstract: | The risk assessment of intracranial aneurysms is an exceedingly difficult task. Clinicians associate aneurysm shape irregularity with disease instability. However, there is no consensus on which shape features reliably predict aneurysm instability. We have adopted a machine learning approach to identify shape features with predictive power for aneurysm instability: From imaging data 3D models of aneurysms are extracted that are used to train a classifier. A variety of representations of the 3D shape are calculated, these include the Zernike moment invariants (ZMI) and geometry indices such as aspect ratio, ellipticity and non-sphericity. The processing pipeline was applied to synthetic data and clinical datasets of 413 aneurysms registered in the AneurysmDataBase (SwissNeuroFoundation) and AneuriskWeb database. Classification based on ZMI alone allowed us to distinguish between sidewall and bifurcation aneurysms, but failed to forecast an aneurysm’s rupture status reliably. Simpler geometry indices performed similarly well in rupture status prediction. On synthetic data we showed that ZMI could encode shape irregularity. It remains to be investigated whether further stratification of the aneurysms in terms of location, size and clinical factors will increase the robustness of the applied classification methods. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/12073 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Computational Life Sciences (ICLS) |
| Published as part of the ZHAW project: | AneuX |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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Juchler, N., Schilling, S., Vartan, K., & Hirsch, S. (2016, September 15). Shape-based assessment of intracranial aneurysm disease status. ZNZ Symposium 2016, Zurich, 15. September 2016.
Juchler, N. et al. (2016) ‘Shape-based assessment of intracranial aneurysm disease status’, in ZNZ Symposium 2016, Zurich, 15. September 2016.
N. Juchler, S. Schilling, K. Vartan, and S. Hirsch, “Shape-based assessment of intracranial aneurysm disease status,” in ZNZ Symposium 2016, Zurich, 15. September 2016, Sep. 2016.
JUCHLER, Norman, Sabine SCHILLING, Kurtcuoglu VARTAN und Sven HIRSCH, 2016. Shape-based assessment of intracranial aneurysm disease status. In: ZNZ Symposium 2016, Zurich, 15. September 2016. Conference poster. 15 September 2016
Juchler, Norman, Sabine Schilling, Kurtcuoglu Vartan, and Sven Hirsch. 2016. “Shape-Based Assessment of Intracranial Aneurysm Disease Status.” Conference poster. In ZNZ Symposium 2016, Zurich, 15. September 2016.
Juchler, Norman, et al. “Shape-Based Assessment of Intracranial Aneurysm Disease Status.” ZNZ Symposium 2016, Zurich, 15. September 2016, 2016.
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