Please use this identifier to cite or link to this item:
https://doi.org/10.21256/zhaw-4769| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Advances in the biofabrication of 3D skin in vitro : healthy and pathological models |
| Authors: | Randall, Matthew J. Jüngel, Astrid Rimann, Markus Wuertz-Kozak, Karin |
| DOI: | 10.21256/zhaw-4769 10.3389/fbioe.2018.00154 |
| Published in: | Frontiers in Bioengineering and Biotechnology |
| Volume(Issue): | 6 |
| Issue: | 154 |
| Page(s): | 154 |
| Issue Date: | 31-Oct-2018 |
| Publisher / Ed. Institution: | Frontiers Research Foundation |
| ISSN: | 2296-4185 |
| Language: | English |
| Subjects: | 3D tissue model; Biofabrication; Bioprinting; Electrospinning; In vitro; Preclinical testing; Skin; Skin disease |
| Subject (DDC): | 610: Medicine and health 660.6: Biotechnology |
| Abstract: | The relevance for in vitro three-dimensional (3D) tissue culture of skin has been present for almost a century. From using skin biopsies in organ culture, to vascularized organotypic full-thickness reconstructed human skin equivalents, in vitro tissue regeneration of 3D skin has reached a golden era. However, the reconstruction of 3D skin still has room to grow and develop. The need for reproducible methodology, physiological structures and tissue architecture, and perfusable vasculature are only recently becoming a reality, though the addition of more complex structures such as glands and tactile corpuscles require advanced technologies. In this review, we will discuss the current methodology for biofabrication of 3D skin models and highlight the advantages and disadvantages of the existing systems as well as emphasize how new techniques can aid in the production of a truly physiologically relevant skin construct for preclinical innovation. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/13235 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY 4.0: Attribution 4.0 International |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2018_Randall_Advances_in_the_biofabrication_fbioe-06-00154.pdf | 1.78 MB | Adobe PDF |  View/Open |
Show full item record
Randall, M. J., Jüngel, A., Rimann, M., & Wuertz-Kozak, K. (2018). Advances in the biofabrication of 3D skin in vitro : healthy and pathological models. Frontiers in Bioengineering and Biotechnology, 6(154), 154. https://doi.org/10.21256/zhaw-4769
Randall, M.J. et al. (2018) ‘Advances in the biofabrication of 3D skin in vitro : healthy and pathological models’, Frontiers in Bioengineering and Biotechnology, 6(154), p. 154. Available at: https://doi.org/10.21256/zhaw-4769.
M. J. Randall, A. Jüngel, M. Rimann, and K. Wuertz-Kozak, “Advances in the biofabrication of 3D skin in vitro : healthy and pathological models,” Frontiers in Bioengineering and Biotechnology, vol. 6, no. 154, p. 154, Oct. 2018, doi: 10.21256/zhaw-4769.
RANDALL, Matthew J., Astrid JÜNGEL, Markus RIMANN und Karin WUERTZ-KOZAK, 2018. Advances in the biofabrication of 3D skin in vitro : healthy and pathological models. Frontiers in Bioengineering and Biotechnology. 31 Oktober 2018. Bd. 6, Nr. 154, S. 154. DOI 10.21256/zhaw-4769
Randall, Matthew J., Astrid Jüngel, Markus Rimann, and Karin Wuertz-Kozak. 2018. “Advances in the Biofabrication of 3D Skin in Vitro : Healthy and Pathological Models.” Frontiers in Bioengineering and Biotechnology 6 (154): 154. https://doi.org/10.21256/zhaw-4769.
Randall, Matthew J., et al. “Advances in the Biofabrication of 3D Skin in Vitro : Healthy and Pathological Models.” Frontiers in Bioengineering and Biotechnology, vol. 6, no. 154, Oct. 2018, p. 154, https://doi.org/10.21256/zhaw-4769.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.