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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Advances in the biofabrication of 3D skin in vitro : healthy and pathological models
Authors: Randall, Matthew J.
Jüngel, Astrid
Rimann, Markus
Wuertz-Kozak, Karin
DOI: 10.21256/zhaw-4769
Published in: Frontiers in Bioengineering and Biotechnology
Volume(Issue): 6
Issue: 154
Pages: 154
Issue Date: 31-Oct-2018
Publisher / Ed. Institution: Frontiers Research Foundation
ISSN: 2296-4185
Language: English
Subjects: 3D tissue model; Biofabrication; Bioprinting; Electrospinning; In vitro; Preclinical testing; Skin; Skin disease
Subject (DDC): 610: Medicine and health
660.6: Biotechnology
Abstract: The relevance for in vitro three-dimensional (3D) tissue culture of skin has been present for almost a century. From using skin biopsies in organ culture, to vascularized organotypic full-thickness reconstructed human skin equivalents, in vitro tissue regeneration of 3D skin has reached a golden era. However, the reconstruction of 3D skin still has room to grow and develop. The need for reproducible methodology, physiological structures and tissue architecture, and perfusable vasculature are only recently becoming a reality, though the addition of more complex structures such as glands and tactile corpuscles require advanced technologies. In this review, we will discuss the current methodology for biofabrication of 3D skin models and highlight the advantages and disadvantages of the existing systems as well as emphasize how new techniques can aid in the production of a truly physiologically relevant skin construct for preclinical innovation.
Fulltext version: Published version
License (according to publishing contract): CC BY 4.0: Attribution 4.0 International
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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