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  2. School of Engineering
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  4. Publikationen School of Engineering
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dc.contributor.authorDürr, Oliver-
dc.contributor.authorDuval, François-
dc.contributor.authorNichols, Anthony-
dc.contributor.authorLang, Paul-
dc.contributor.authorBrodte, Annette-
dc.contributor.authorHeyse, Stephan-
dc.contributor.authorBesson, Dominique-
dc.date.accessioned2018-12-17T08:15:47Z-
dc.date.available2018-12-17T08:15:47Z-
dc.date.issued2007-
dc.identifier.issn1087-0571de_CH
dc.identifier.issn1552-454Xde_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/13890-
dc.description.abstractRecent technological advances in high-content screening instrumentation have increased its ease of use and throughput, expanding the application of high-content screening to the early stages of drug discovery. However, high-content screens produce complex data sets, presenting a challenge for both extraction and interpretation of meaningful information. This shifts the high-content screening process bottleneck from the experimental to the analytical stage. In this article, the authors discuss different approaches of data analysis, using a phenotypic neurite outgrowth screen as an example. Distance measurements and hierarchical clustering methods lead to a profound understanding of different high-content screening readouts. In addition, the authors introduce a hit selection procedure based on machine learning methods and demonstrate that this method increases the hit verification rate significantly (up to a factor of 5), compared to conventional hit selection based on single readouts only.de_CH
dc.language.isoende_CH
dc.publisherSagede_CH
dc.relation.ispartofJournal of Biomolecular Screeningde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectCluster analysisde_CH
dc.subjectMultivariate analysisde_CH
dc.subjectNeuritesde_CH
dc.subjectQuality controlde_CH
dc.subjectReproducibility of resultsde_CH
dc.subjectTissue array analysisde_CH
dc.subject.ddc572: Biochemiede_CH
dc.titleRobust hit identification by quality assurance and multivariate data analysis of a high-content, cell-based assayde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Engineeringde_CH
zhaw.organisationalunitInstitut für Datenanalyse und Prozessdesign (IDP)de_CH
dc.identifier.doi10.1177/1087057107309036de_CH
dc.identifier.pmid18087069de_CH
zhaw.funding.euNode_CH
zhaw.issue8de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.end1049de_CH
zhaw.pages.start1042de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume12de_CH
zhaw.publication.reviewNot specifiedde_CH
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Dürr, O., Duval, F., Nichols, A., Lang, P., Brodte, A., Heyse, S., & Besson, D. (2007). Robust hit identification by quality assurance and multivariate data analysis of a high-content, cell-based assay. Journal of Biomolecular Screening, 12(8), 1042–1049. https://doi.org/10.1177/1087057107309036
Dürr, O. et al. (2007) ‘Robust hit identification by quality assurance and multivariate data analysis of a high-content, cell-based assay’, Journal of Biomolecular Screening, 12(8), pp. 1042–1049. Available at: https://doi.org/10.1177/1087057107309036.
O. Dürr et al., “Robust hit identification by quality assurance and multivariate data analysis of a high-content, cell-based assay,” Journal of Biomolecular Screening, vol. 12, no. 8, pp. 1042–1049, 2007, doi: 10.1177/1087057107309036.
DÜRR, Oliver, François DUVAL, Anthony NICHOLS, Paul LANG, Annette BRODTE, Stephan HEYSE und Dominique BESSON, 2007. Robust hit identification by quality assurance and multivariate data analysis of a high-content, cell-based assay. Journal of Biomolecular Screening. 2007. Bd. 12, Nr. 8, S. 1042–1049. DOI 10.1177/1087057107309036
Dürr, Oliver, François Duval, Anthony Nichols, Paul Lang, Annette Brodte, Stephan Heyse, and Dominique Besson. 2007. “Robust Hit Identification by Quality Assurance and Multivariate Data Analysis of a High-Content, Cell-Based Assay.” Journal of Biomolecular Screening 12 (8): 1042–49. https://doi.org/10.1177/1087057107309036.
Dürr, Oliver, et al. “Robust Hit Identification by Quality Assurance and Multivariate Data Analysis of a High-Content, Cell-Based Assay.” Journal of Biomolecular Screening, vol. 12, no. 8, 2007, pp. 1042–49, https://doi.org/10.1177/1087057107309036.


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