Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dürr, Oliver | - |
dc.contributor.author | Duval, François | - |
dc.contributor.author | Nichols, Anthony | - |
dc.contributor.author | Lang, Paul | - |
dc.contributor.author | Brodte, Annette | - |
dc.contributor.author | Heyse, Stephan | - |
dc.contributor.author | Besson, Dominique | - |
dc.date.accessioned | 2018-12-17T08:15:47Z | - |
dc.date.available | 2018-12-17T08:15:47Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1087-0571 | de_CH |
dc.identifier.issn | 1552-454X | de_CH |
dc.identifier.uri | https://digitalcollection.zhaw.ch/handle/11475/13890 | - |
dc.description.abstract | Recent technological advances in high-content screening instrumentation have increased its ease of use and throughput, expanding the application of high-content screening to the early stages of drug discovery. However, high-content screens produce complex data sets, presenting a challenge for both extraction and interpretation of meaningful information. This shifts the high-content screening process bottleneck from the experimental to the analytical stage. In this article, the authors discuss different approaches of data analysis, using a phenotypic neurite outgrowth screen as an example. Distance measurements and hierarchical clustering methods lead to a profound understanding of different high-content screening readouts. In addition, the authors introduce a hit selection procedure based on machine learning methods and demonstrate that this method increases the hit verification rate significantly (up to a factor of 5), compared to conventional hit selection based on single readouts only. | de_CH |
dc.language.iso | en | de_CH |
dc.publisher | Sage | de_CH |
dc.relation.ispartof | Journal of Biomolecular Screening | de_CH |
dc.rights | Licence according to publishing contract | de_CH |
dc.subject | Cluster analysis | de_CH |
dc.subject | Multivariate analysis | de_CH |
dc.subject | Neurites | de_CH |
dc.subject | Quality control | de_CH |
dc.subject | Reproducibility of results | de_CH |
dc.subject | Tissue array analysis | de_CH |
dc.subject.ddc | 572: Biochemie | de_CH |
dc.title | Robust hit identification by quality assurance and multivariate data analysis of a high-content, cell-based assay | de_CH |
dc.type | Beitrag in wissenschaftlicher Zeitschrift | de_CH |
dcterms.type | Text | de_CH |
zhaw.departement | School of Engineering | de_CH |
zhaw.organisationalunit | Institut für Datenanalyse und Prozessdesign (IDP) | de_CH |
dc.identifier.doi | 10.1177/1087057107309036 | de_CH |
dc.identifier.pmid | 18087069 | de_CH |
zhaw.funding.eu | No | de_CH |
zhaw.issue | 8 | de_CH |
zhaw.originated.zhaw | No | de_CH |
zhaw.pages.end | 1049 | de_CH |
zhaw.pages.start | 1042 | de_CH |
zhaw.publication.status | publishedVersion | de_CH |
zhaw.volume | 12 | de_CH |
zhaw.publication.review | Not specified | de_CH |
Appears in collections: | Publikationen School of Engineering |
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Dürr, O., Duval, F., Nichols, A., Lang, P., Brodte, A., Heyse, S., & Besson, D. (2007). Robust hit identification by quality assurance and multivariate data analysis of a high-content, cell-based assay. Journal of Biomolecular Screening, 12(8), 1042–1049. https://doi.org/10.1177/1087057107309036
Dürr, O. et al. (2007) ‘Robust hit identification by quality assurance and multivariate data analysis of a high-content, cell-based assay’, Journal of Biomolecular Screening, 12(8), pp. 1042–1049. Available at: https://doi.org/10.1177/1087057107309036.
O. Dürr et al., “Robust hit identification by quality assurance and multivariate data analysis of a high-content, cell-based assay,” Journal of Biomolecular Screening, vol. 12, no. 8, pp. 1042–1049, 2007, doi: 10.1177/1087057107309036.
DÜRR, Oliver, François DUVAL, Anthony NICHOLS, Paul LANG, Annette BRODTE, Stephan HEYSE und Dominique BESSON, 2007. Robust hit identification by quality assurance and multivariate data analysis of a high-content, cell-based assay. Journal of Biomolecular Screening. 2007. Bd. 12, Nr. 8, S. 1042–1049. DOI 10.1177/1087057107309036
Dürr, Oliver, François Duval, Anthony Nichols, Paul Lang, Annette Brodte, Stephan Heyse, and Dominique Besson. 2007. “Robust Hit Identification by Quality Assurance and Multivariate Data Analysis of a High-Content, Cell-Based Assay.” Journal of Biomolecular Screening 12 (8): 1042–49. https://doi.org/10.1177/1087057107309036.
Dürr, Oliver, et al. “Robust Hit Identification by Quality Assurance and Multivariate Data Analysis of a High-Content, Cell-Based Assay.” Journal of Biomolecular Screening, vol. 12, no. 8, 2007, pp. 1042–49, https://doi.org/10.1177/1087057107309036.
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