Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Quantifying bioactivity on a large scale : quality assurance and analysis of multiparametric ultra-HTS data
Authors: Heyse, Stephan
Brodte, Annette
Bruttger, Oliver
Dürr, Oliver
Freeman, Tobe
Jung, Tom
Lindemann, Michael
Ottl, Johannes
Rinn, Bernd
DOI: 10.1016/j.jala.2005.05.003
Published in: SLAS Technology: Translating Life Sciences Innovation
Volume(Issue): 10
Issue: 4
Page(s): 207
Pages to: 212
Issue Date: 2005
Publisher / Ed. Institution: Sage
ISSN: 2472-6303
2472-6311
Language: English
Subject (DDC): 572: Biochemistry
615: Pharmacology and therapeutics
Abstract: There is a growing need to precisely quantify the selectivity of large compound sets in high throughput screening, directing investment in lead optimization towards compounds with a high chance of success. High-content, high-density screening technologies such as multiparametric ultra-HTS provide a basis for highly precise screening with unprecedented scope for delineating process artifacts from reliable signals. However, the full potential of these technologies can only be realized with suitable experimental design and sophisticated data analysis tools. We present two advanced analysis workflows demonstrating how multiparametric readouts from a high throughput primary screen can improve decision quality in the hit identification process. The first involves discrete thresholding and the application of multiple selection criteria. The second uses machine learning algorithms and allows an unbiased consideration of all measured parameters.
URI: https://digitalcollection.zhaw.ch/handle/11475/13897
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: School of Engineering
Organisational Unit: Institute of Data Analysis and Process Design (IDP)
Appears in collections:Publikationen School of Engineering

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Heyse, S., Brodte, A., Bruttger, O., Dürr, O., Freeman, T., Jung, T., Lindemann, M., Ottl, J., & Rinn, B. (2005). Quantifying bioactivity on a large scale : quality assurance and analysis of multiparametric ultra-HTS data. SLAS Technology: Translating Life Sciences Innovation, 10(4), 207–212. https://doi.org/10.1016/j.jala.2005.05.003
Heyse, S. et al. (2005) ‘Quantifying bioactivity on a large scale : quality assurance and analysis of multiparametric ultra-HTS data’, SLAS Technology: Translating Life Sciences Innovation, 10(4), pp. 207–212. Available at: https://doi.org/10.1016/j.jala.2005.05.003.
S. Heyse et al., “Quantifying bioactivity on a large scale : quality assurance and analysis of multiparametric ultra-HTS data,” SLAS Technology: Translating Life Sciences Innovation, vol. 10, no. 4, pp. 207–212, 2005, doi: 10.1016/j.jala.2005.05.003.
HEYSE, Stephan, Annette BRODTE, Oliver BRUTTGER, Oliver DÜRR, Tobe FREEMAN, Tom JUNG, Michael LINDEMANN, Johannes OTTL und Bernd RINN, 2005. Quantifying bioactivity on a large scale : quality assurance and analysis of multiparametric ultra-HTS data. SLAS Technology: Translating Life Sciences Innovation. 2005. Bd. 10, Nr. 4, S. 207–212. DOI 10.1016/j.jala.2005.05.003
Heyse, Stephan, Annette Brodte, Oliver Bruttger, Oliver Dürr, Tobe Freeman, Tom Jung, Michael Lindemann, Johannes Ottl, and Bernd Rinn. 2005. “Quantifying Bioactivity on a Large Scale : Quality Assurance and Analysis of Multiparametric Ultra-HTS Data.” SLAS Technology: Translating Life Sciences Innovation 10 (4): 207–12. https://doi.org/10.1016/j.jala.2005.05.003.
Heyse, Stephan, et al. “Quantifying Bioactivity on a Large Scale : Quality Assurance and Analysis of Multiparametric Ultra-HTS Data.” SLAS Technology: Translating Life Sciences Innovation, vol. 10, no. 4, 2005, pp. 207–12, https://doi.org/10.1016/j.jala.2005.05.003.


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