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dc.contributor.authorPeters, Christin-
dc.contributor.authorBuller, Rebecca-
dc.date.accessioned2019-02-16T09:31:32Z-
dc.date.available2019-02-16T09:31:32Z-
dc.date.issued2019-
dc.identifier.issn1865-7125de_CH
dc.identifier.issn0939-5075de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/15397-
dc.description.abstractBiocatalysis has developed enormously in the last decade and now offers solutions for the sustainable production of chiral and highly functionalised asset molecules. Products generated by enzymatic transformations are already being used in the food, feed, chemical, pharmaceutical and cosmetic industry, and the accessible compound panoply is expected to expand even further. In particular, the combination of stereo-selective enzymes in linear cascade reactions is an elegant strategy toward enantiomeric pure compounds, as it reduces the number of isolation and purification steps and avoids accumulation of potentially unstable intermediates. Here, we present the set-up of an enzyme cascade to selectively convert citral to (-)-iso-isopulegol by combining an ene reductase and a squalene hopene cyclase. In the initial reaction step, the ene reductase YqjM from Bacillus subtilis selectively transforms citral to (S)-citronellal, which is subsequently cyclised exclusively to (-)-iso-isopulegol by a mutant of the squalene hopene cyclase from Alicyclobacillus acidocaldarius (AacSHC). With this approach, we can convert citral to an enantiopure precursor for isomenthol derivatives.de_CH
dc.language.isoende_CH
dc.publisherDe Gruyterde_CH
dc.relation.ispartofZeitschrift für Naturforschung Cde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject(–)-iso-isopulegolde_CH
dc.subjectBiocatalysisde_CH
dc.subjectEne reductasesde_CH
dc.subjectEnzyme cascadede_CH
dc.subjectSqualene hopene cyclasesde_CH
dc.subject.ddc660.6: Biotechnologiede_CH
dc.titleLinear enzyme cascade for the production of (–)-iso-isopulegolde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1515/znc-2018-0146de_CH
dc.identifier.pmid30645192de_CH
zhaw.funding.euNode_CH
zhaw.issue3-4de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume74de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedBiokatalysede_CH
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Peters, C., & Buller, R. (2019). Linear enzyme cascade for the production of (–)-iso-isopulegol. Zeitschrift Für Naturforschung C, 74(3-4). https://doi.org/10.1515/znc-2018-0146
Peters, C. and Buller, R. (2019) ‘Linear enzyme cascade for the production of (–)-iso-isopulegol’, Zeitschrift für Naturforschung C, 74(3-4). Available at: https://doi.org/10.1515/znc-2018-0146.
C. Peters and R. Buller, “Linear enzyme cascade for the production of (–)-iso-isopulegol,” Zeitschrift für Naturforschung C, vol. 74, no. 3-4, 2019, doi: 10.1515/znc-2018-0146.
PETERS, Christin und Rebecca BULLER, 2019. Linear enzyme cascade for the production of (–)-iso-isopulegol. Zeitschrift für Naturforschung C. 2019. Bd. 74, Nr. 3-4. DOI 10.1515/znc-2018-0146
Peters, Christin, and Rebecca Buller. 2019. “Linear Enzyme Cascade for the Production Of (–)-Iso-Isopulegol.” Zeitschrift Für Naturforschung C 74 (3-4). https://doi.org/10.1515/znc-2018-0146.
Peters, Christin, and Rebecca Buller. “Linear Enzyme Cascade for the Production Of (–)-Iso-Isopulegol.” Zeitschrift Für Naturforschung C, vol. 74, no. 3-4, 2019, https://doi.org/10.1515/znc-2018-0146.


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