Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-3342
Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Improved air quality and attenuated lung function decline : modification by obesity in the SAPALDIA cohort
Authors: Schikowski, Tamara
Schaffner, Emmanuel
Meier, Flurina
Phuleria, Harish C.
Vierkötter, Andrea
Schindler, Christian
Kriemler, Susi
Zemp, Elisabeth
Krämer, Ursula
Bridevaux, Pierre-Olivier
Rochat, Thierry
Schwart, Joel
Künzli, Nino
Probst-Hensch, Nicole
DOI: 10.21256/zhaw-3342
10.1289/ehp.1206145
Published in: Environmental Health Perspectives
Volume(Issue): 121
Issue: 9
Page(s): 1034
Pages to: 1039
Issue Date: 2013
Publisher / Ed. Institution: National Institute of Environmental Health Sciences
ISSN: 0091-6765
1552-9924
Language: English
Subject (DDC): 616: Internal medicine and diseases
Abstract: Background: Air pollution and obesity are hypothesized to contribute to accelerated decline in lung function with age through their inflammatory properties. Objective: We investigated whether the previously reported association between improved air quality and lung health in the population-based SAPALDIA cohort is modified by obesity. Methods: We used adjusted mixed-model analyses to estimate the association of average body mass index (BMI) and changes in particulate matter with aerodynamic diameter = 10 µm (PM10; ΔPM10) with lung function decline over a 10-year follow-up period. Results: Lung function data and complete information were available for 4,664 participants. Age-related declines in lung function among participants with high average BMI were more rapid for FVC (forced vital capacity), but slower for FEV1/FVC (forced expiratory volume in 1 sec/FVC) and FEF25-75 (forced expiratory flow at 25-75%) than declines among those with low or normal average BMI. Improved air quality was associated with attenuated reductions in FEV1/FVC, FEF25-75, and FEF25-75/FVC over time among low- and normal-BMI participants, but not overweight or obese participants. The attenuation was most pronounced for ΔFEF25-75/FVC (30% and 22% attenuation in association with a 10-µg/m3 decrease in PM10 among low- and normal-weight participants, respectively.) Conclusion: Our results point to the importance of considering health effects of air pollution exposure and obesity in parallel. Further research must address the mechanisms underlying the observed interaction.
Further description: All documents published by EHP are in the public domain. PDF copies of published articles can be freely shared and distributed without permission from either EHP or the authors.
URI: https://digitalcollection.zhaw.ch/handle/11475/16419
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: School of Management and Law
Organisational Unit: Winterthur Institute of Health Economics (WIG)
Appears in collections:Publikationen School of Management and Law

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Schikowski, T., Schaffner, E., Meier, F., Phuleria, H. C., Vierkötter, A., Schindler, C., Kriemler, S., Zemp, E., Krämer, U., Bridevaux, P.-O., Rochat, T., Schwart, J., Künzli, N., & Probst-Hensch, N. (2013). Improved air quality and attenuated lung function decline : modification by obesity in the SAPALDIA cohort. Environmental Health Perspectives, 121(9), 1034–1039. https://doi.org/10.21256/zhaw-3342
Schikowski, T. et al. (2013) ‘Improved air quality and attenuated lung function decline : modification by obesity in the SAPALDIA cohort’, Environmental Health Perspectives, 121(9), pp. 1034–1039. Available at: https://doi.org/10.21256/zhaw-3342.
T. Schikowski et al., “Improved air quality and attenuated lung function decline : modification by obesity in the SAPALDIA cohort,” Environmental Health Perspectives, vol. 121, no. 9, pp. 1034–1039, 2013, doi: 10.21256/zhaw-3342.
SCHIKOWSKI, Tamara, Emmanuel SCHAFFNER, Flurina MEIER, Harish C. PHULERIA, Andrea VIERKÖTTER, Christian SCHINDLER, Susi KRIEMLER, Elisabeth ZEMP, Ursula KRÄMER, Pierre-Olivier BRIDEVAUX, Thierry ROCHAT, Joel SCHWART, Nino KÜNZLI und Nicole PROBST-HENSCH, 2013. Improved air quality and attenuated lung function decline : modification by obesity in the SAPALDIA cohort. Environmental Health Perspectives. 2013. Bd. 121, Nr. 9, S. 1034–1039. DOI 10.21256/zhaw-3342
Schikowski, Tamara, Emmanuel Schaffner, Flurina Meier, Harish C. Phuleria, Andrea Vierkötter, Christian Schindler, Susi Kriemler, et al. 2013. “Improved Air Quality and Attenuated Lung Function Decline : Modification by Obesity in the SAPALDIA Cohort.” Environmental Health Perspectives 121 (9): 1034–39. https://doi.org/10.21256/zhaw-3342.
Schikowski, Tamara, et al. “Improved Air Quality and Attenuated Lung Function Decline : Modification by Obesity in the SAPALDIA Cohort.” Environmental Health Perspectives, vol. 121, no. 9, 2013, pp. 1034–39, https://doi.org/10.21256/zhaw-3342.


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