Alpha-1 antitrypsin deficiency : from the lung to the heart?

Curjuric, Ivan; Imboden, Medea; Bettschart, Robert; Caviezel, Seraina; Dratva, Julia; Pons, Marco; Rothe, Thomas; Schmidt-Trucksäss, Arno; Stolz, Daiana; Thun, Gian Andri; von Eckardstein, Arnold; Kronenberg, Florian; Ferrarotti, Ilaria; Probst-Hensch, Nicole M

doi:10.1016/j.atherosclerosis.2018.01.042

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Alpha-1 antitrypsin deficiency : from the lung to the heart?
Authors:	Curjuric, Ivan Imboden, Medea Bettschart, Robert Caviezel, Seraina Dratva, Julia Pons, Marco Rothe, Thomas Schmidt-Trucksäss, Arno Stolz, Daiana Thun, Gian Andri von Eckardstein, Arnold Kronenberg, Florian Ferrarotti, Ilaria Probst-Hensch, Nicole M
et. al:	No
DOI:	10.1016/j.atherosclerosis.2018.01.042
Published in:	Atherosclerosis
Volume(Issue):	270
Page(s):	166
Pages to:	172
Issue Date:	2018
Publisher / Ed. Institution:	Elsevier
ISSN:	1879-1484 0021-9150
Language:	English
Subjects:	Alpha-1 antitrypsin deficiency; Cardiovascular disease; Cohort study; MESH): carotid intima-media thickness; Mendelian randomization analysis; Aged; Blood pressure; Carotid artery disease; Carotid intima-media thickness; Female; Genetic predisposition to disease; Human; Hypertension; Male; Mendelian randomization analysis; Middle aged; Phenotype; Pulmonary disease, chronic obstructive; Risk assessment; Risk factor; Switzerland; alpha 1-antitrypsin; alpha 1-antitrypsin deficiency; Mutation
Subject (DDC):	616: Internal medicine and diseases
Abstract:	Alpha-1 antitrypsin (A1AT) is the most abundant serine protease inhibitor in human blood and exerts important anti-inflammatory and immune-modulatory effects. In combination with smoking or other long-term noxious exposures such as occupational dust and fumes, genetic A1AT deficiency can cause chronic obstructive pulmonary disease, a condition with elevated cardiovascular risk. The effects of A1AT deficiency on cardiovascular risk have hardly been studied today.
URI:	https://digitalcollection.zhaw.ch/handle/11475/17594
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	School of Health Sciences
Organisational Unit:	Institute of Public Health (IPH)
Appears in collections:	Publikationen Gesundheit

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Curjuric, I., Imboden, M., Bettschart, R., Caviezel, S., Dratva, J., Pons, M., Rothe, T., Schmidt-Trucksäss, A., Stolz, D., Thun, G. A., von Eckardstein, A., Kronenberg, F., Ferrarotti, I., & Probst-Hensch, N. M. (2018). Alpha-1 antitrypsin deficiency : from the lung to the heart? Atherosclerosis, 270, 166–172. https://doi.org/10.1016/j.atherosclerosis.2018.01.042

Curjuric, I. et al. (2018) ‘Alpha-1 antitrypsin deficiency : from the lung to the heart?’, Atherosclerosis, 270, pp. 166–172. Available at: https://doi.org/10.1016/j.atherosclerosis.2018.01.042.

I. Curjuric et al., “Alpha-1 antitrypsin deficiency : from the lung to the heart?,” Atherosclerosis, vol. 270, pp. 166–172, 2018, doi: 10.1016/j.atherosclerosis.2018.01.042.

CURJURIC, Ivan, Medea IMBODEN, Robert BETTSCHART, Seraina CAVIEZEL, Julia DRATVA, Marco PONS, Thomas ROTHE, Arno SCHMIDT-TRUCKSÄSS, Daiana STOLZ, Gian Andri THUN, Arnold VON ECKARDSTEIN, Florian KRONENBERG, Ilaria FERRAROTTI und Nicole M PROBST-HENSCH, 2018. Alpha-1 antitrypsin deficiency : from the lung to the heart? Atherosclerosis. 2018. Bd. 270, S. 166–172. DOI 10.1016/j.atherosclerosis.2018.01.042

Curjuric, Ivan, Medea Imboden, Robert Bettschart, Seraina Caviezel, Julia Dratva, Marco Pons, Thomas Rothe, et al. 2018. “Alpha-1 Antitrypsin Deficiency : From the Lung to the Heart?” Atherosclerosis 270: 166–72. https://doi.org/10.1016/j.atherosclerosis.2018.01.042.

Curjuric, Ivan, et al. “Alpha-1 Antitrypsin Deficiency : From the Lung to the Heart?” Atherosclerosis, vol. 270, 2018, pp. 166–72, https://doi.org/10.1016/j.atherosclerosis.2018.01.042.