Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-18730
Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Towards 99mTc- and Re-based multifunctional silica platforms for theranostic applications
Authors: Wuillemin, Michel A.
Reber, Michael
Fox, Thomas
Spingler, Bernhard
Brühwiler, Dominik
Alberto, Roger
Braband, Henrik
et. al: No
DOI: 10.3390/inorganics7110134
10.21256/zhaw-18730
Published in: Inorganics
Volume(Issue): 7
Issue: 11
Page(s): 134
Issue Date: 2019
Publisher / Ed. Institution: MDPI
ISSN: 2304-6740
Language: English
Subjects: Technetium; Rhenium; Complexes; Mesoporous silica; MCM-41; SBA-15; Theranostic; Radioprobe
Subject (DDC): 540: Chemistry
Abstract: Taking advantage of the radiation properties of 99mTc and 186/188Re and the photophysical characteristics of the {M(CO)3}+ moiety (M = Re), we developed a multifunctional silica platform with the theranostic pair 99mTc/Re with high potential for (nano)medical applications. Starting with a general screening to evaluate the most suitable mesoporous silica construct and the development of appropriate chelate systems, multifunctional mesoporous silica microparticles (SBA-15) were synthesized. These particles act as a model towards the synthesis of the corresponding nanoconstructs. The particles can be modified at the external surface with a targeting function and labeled with the {M(CO)3}+ moiety (M = 99mTc, Re) at the pore surface. Thus, a silica platform is realized, whose bioprofile is not altered by the loaded modalities. The described synthetic procedures can be applied to establish a target-specific theranostic nanoplatform, which enables the combination of fluorescence and radio imaging, with the possibility of radio- and chemotherapy.
URI: https://digitalcollection.zhaw.ch/handle/11475/18730
Fulltext version: Published version
License (according to publishing contract): CC BY 4.0: Attribution 4.0 International
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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Wuillemin, M. A., Reber, M., Fox, T., Spingler, B., Brühwiler, D., Alberto, R., & Braband, H. (2019). Towards 99mTc- and Re-based multifunctional silica platforms for theranostic applications. Inorganics, 7(11), 134. https://doi.org/10.3390/inorganics7110134
Wuillemin, M.A. et al. (2019) ‘Towards 99mTc- and Re-based multifunctional silica platforms for theranostic applications’, Inorganics, 7(11), p. 134. Available at: https://doi.org/10.3390/inorganics7110134.
M. A. Wuillemin et al., “Towards 99mTc- and Re-based multifunctional silica platforms for theranostic applications,” Inorganics, vol. 7, no. 11, p. 134, 2019, doi: 10.3390/inorganics7110134.
WUILLEMIN, Michel A., Michael REBER, Thomas FOX, Bernhard SPINGLER, Dominik BRÜHWILER, Roger ALBERTO und Henrik BRABAND, 2019. Towards 99mTc- and Re-based multifunctional silica platforms for theranostic applications. Inorganics. 2019. Bd. 7, Nr. 11, S. 134. DOI 10.3390/inorganics7110134
Wuillemin, Michel A., Michael Reber, Thomas Fox, Bernhard Spingler, Dominik Brühwiler, Roger Alberto, and Henrik Braband. 2019. “Towards 99mTc- and Re-Based Multifunctional Silica Platforms for Theranostic Applications.” Inorganics 7 (11): 134. https://doi.org/10.3390/inorganics7110134.
Wuillemin, Michel A., et al. “Towards 99mTc- and Re-Based Multifunctional Silica Platforms for Theranostic Applications.” Inorganics, vol. 7, no. 11, 2019, p. 134, https://doi.org/10.3390/inorganics7110134.


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