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https://doi.org/10.21256/zhaw-19319| Publication type: | Book part |
| Type of review: | Editorial review |
| Title: | Development, engineering and biological characterization of stirred tank bioreactors |
| Authors: | Schirmer, Cedric Nussbaumer, Thomas Schöb, Reto Pörtner, Ralf Eibl-Schindler, Regine Eibl, Dieter |
| et. al: | No |
| DOI: | 10.5772/intechopen.79444 10.21256/zhaw-19319 |
| Published in: | Biopharmaceuticals |
| Editors of the parent work: | Yeh, Ming-Kung Chen, Yuan-Chuan |
| Page(s): | 87 |
| Pages to: | 107 |
| Issue Date: | 2018 |
| Publisher / Ed. Institution: | IntechOpen |
| Publisher / Ed. Institution: | London |
| ISBN: | 978-1-78923-718-4 978-1-78923-719-1 |
| Language: | English |
| Subjects: | Stirred bioreactor; Characterization; Mixing time; Power input; Volumetric mass transfer coefficient; Development; Cultivation system |
| Subject (DDC): | 660: Chemical engineering |
| Abstract: | Stirred tank bioreactors are still the predominant cultivation systems in large scale biopharmaceutical production. Today, several manufacturers provide both reusable and single-use systems, whereas the broad variety of designs and properties lead to deviations in biological performance. Although the methods for bioreactor characterization are well established, varying experimental conditions and procedures can result in significantly different outcomes. In order to guarantee a reliable comparison and evaluation of different single-use and reusable bioreactor types, standardized methods for their characterization are needed. Equally important is the biological capability of bioreactors, which must be accessed by standardized cultivation procedures of industrially relevant organisms (bacteria, yeasts as well as mammalian and animal cell cultures). In addition, the implementation of well-defined uniform procedures for biological and engineering characterization during the development phase can support a fast assessment of the suitability of a bioreactor system. Based on stirred bioreactors, we describe the aspects of the engineering characterization in order to discuss further the biological characterization as a valuable complement. Finally, a case study is presented. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/19319 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY 3.0: Attribution 3.0 Unported |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2019Schirmer-etal_Development, Engineering and Biological Characterization of Stirred Tank Bioreactors.pdf | 3.91 MB | Adobe PDF |  View/Open |
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Schirmer, C., Nussbaumer, T., Schöb, R., Pörtner, R., Eibl-Schindler, R., & Eibl, D. (2018). Development, engineering and biological characterization of stirred tank bioreactors. In M.-K. Yeh & Y.-C. Chen (Eds.), Biopharmaceuticals (pp. 87–107). IntechOpen. https://doi.org/10.5772/intechopen.79444
Schirmer, C. et al. (2018) ‘Development, engineering and biological characterization of stirred tank bioreactors’, in M.-K. Yeh and Y.-C. Chen (eds) Biopharmaceuticals. London: IntechOpen, pp. 87–107. Available at: https://doi.org/10.5772/intechopen.79444.
C. Schirmer, T. Nussbaumer, R. Schöb, R. Pörtner, R. Eibl-Schindler, and D. Eibl, “Development, engineering and biological characterization of stirred tank bioreactors,” in Biopharmaceuticals, M.-K. Yeh and Y.-C. Chen, Eds. London: IntechOpen, 2018, pp. 87–107. doi: 10.5772/intechopen.79444.
SCHIRMER, Cedric, Thomas NUSSBAUMER, Reto SCHÖB, Ralf PÖRTNER, Regine EIBL-SCHINDLER und Dieter EIBL, 2018. Development, engineering and biological characterization of stirred tank bioreactors. In: Ming-Kung YEH und Yuan-Chuan CHEN (Hrsg.), Biopharmaceuticals. London: IntechOpen. S. 87–107. ISBN 978-1-78923-718-4
Schirmer, Cedric, Thomas Nussbaumer, Reto Schöb, Ralf Pörtner, Regine Eibl-Schindler, and Dieter Eibl. 2018. “Development, Engineering and Biological Characterization of Stirred Tank Bioreactors.” In Biopharmaceuticals, edited by Ming-Kung Yeh and Yuan-Chuan Chen, 87–107. London: IntechOpen. https://doi.org/10.5772/intechopen.79444.
Schirmer, Cedric, et al. “Development, Engineering and Biological Characterization of Stirred Tank Bioreactors.” Biopharmaceuticals, edited by Ming-Kung Yeh and Yuan-Chuan Chen, IntechOpen, 2018, pp. 87–107, https://doi.org/10.5772/intechopen.79444.
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