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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-20307
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dc.contributor.authorWade-Bohleber, L.M.-
dc.contributor.authorBöker, H.-
dc.contributor.authorGrimm, S.-
dc.contributor.authorGärtner, M.-
dc.contributor.authorErnst, J.-
dc.contributor.authorRecher, D.A.-
dc.contributor.authorBuergi, N.-
dc.contributor.authorSeifritz, E.-
dc.contributor.authorRichter, A.-
dc.date.accessioned2020-07-27T08:22:59Z-
dc.date.available2020-07-27T08:22:59Z-
dc.date.issued2020-
dc.identifier.issn0165-0327de_CH
dc.identifier.issn1573-2517de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/20307-
dc.description.abstractBackground Depression and the experience of early adversity are associated with impairments in interpersonal and social cognitive functioning. The neural mechanisms involved in these impairments remain insufficiently understood. Methods In a sample of 48 depressed and 50 healthy participants, we explored seed-to-voxel functional connectivity (FC) during the recall of formative relationship episodes using functional magnetic resonance imaging. Results While depressive symptoms were associated with increased FC of brain regions that form an introspective socio-affective network, such as the precuneus, bilateral anterior insula, dorsal anterior cingulate cortex, left amygdala, and medial prefrontal cortex, early adversity linked to decreased FC of brain regions mediating emotion processing such as the bilateral anterior insula and increased FC of the bilateral parahippocampal gyrus. Limitations We report both results that are corrected for the number of seeds tested in FC analyses using strict Bonferroni adjustments and unadjusted results as part of an exploratory analysis. Discussion Our findings suggest that depression and early adversity are associated with differential FC patterns in the brain during the recall of formative relationship episodes. Hyperconnectivity of an introspective socio-affective network associated with depressive symptoms may link to enhanced self-focus and emotional reactivity. Patterns of neural activation associated with early adversity may underpin numbed affective states or enhanced affective memory regulation. Overall, these findings inform about the neural underpinnings of a reflective ability that is predictive of the adaptation to depression and to early adversity and relevant for psychotherapy outcomes.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofJournal of Affective Disordersde_CH
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/de_CH
dc.subjectDepressionde_CH
dc.subjectEarly adversityde_CH
dc.subjectInterpersonal functioningde_CH
dc.subjectSocial cognitionde_CH
dc.subjectAutobiographic memory retrievalde_CH
dc.subjectTask-based functional connectivityde_CH
dc.subject.ddc616.8: Neurologie und Krankheiten des Nervensystemsde_CH
dc.titleDepression is associated with hyperconnectivity of an introspective socio-affective network during the recall of formative relationship episodesde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementAngewandte Psychologiede_CH
zhaw.organisationalunitPsychologisches Institut (PI)de_CH
dc.identifier.doi10.1016/j.jad.2020.05.110de_CH
dc.identifier.doi10.21256/zhaw-20307-
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end534de_CH
zhaw.pages.start522de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume274de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedKlinische Psychologiede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Wade-Bohleber, L. M., Böker, H., Grimm, S., Gärtner, M., Ernst, J., Recher, D. A., Buergi, N., Seifritz, E., & Richter, A. (2020). Depression is associated with hyperconnectivity of an introspective socio-affective network during the recall of formative relationship episodes. Journal of Affective Disorders, 274, 522–534. https://doi.org/10.1016/j.jad.2020.05.110
Wade-Bohleber, L.M. et al. (2020) ‘Depression is associated with hyperconnectivity of an introspective socio-affective network during the recall of formative relationship episodes’, Journal of Affective Disorders, 274, pp. 522–534. Available at: https://doi.org/10.1016/j.jad.2020.05.110.
L. M. Wade-Bohleber et al., “Depression is associated with hyperconnectivity of an introspective socio-affective network during the recall of formative relationship episodes,” Journal of Affective Disorders, vol. 274, pp. 522–534, 2020, doi: 10.1016/j.jad.2020.05.110.
WADE-BOHLEBER, L.M., H. BÖKER, S. GRIMM, M. GÄRTNER, J. ERNST, D.A. RECHER, N. BUERGI, E. SEIFRITZ und A. RICHTER, 2020. Depression is associated with hyperconnectivity of an introspective socio-affective network during the recall of formative relationship episodes. Journal of Affective Disorders. 2020. Bd. 274, S. 522–534. DOI 10.1016/j.jad.2020.05.110
Wade-Bohleber, L.M., H. Böker, S. Grimm, M. Gärtner, J. Ernst, D.A. Recher, N. Buergi, E. Seifritz, and A. Richter. 2020. “Depression Is Associated with Hyperconnectivity of an Introspective Socio-Affective Network during the Recall of Formative Relationship Episodes.” Journal of Affective Disorders 274: 522–34. https://doi.org/10.1016/j.jad.2020.05.110.
Wade-Bohleber, L. M., et al. “Depression Is Associated with Hyperconnectivity of an Introspective Socio-Affective Network during the Recall of Formative Relationship Episodes.” Journal of Affective Disorders, vol. 274, 2020, pp. 522–34, https://doi.org/10.1016/j.jad.2020.05.110.


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