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dc.contributor.authorSchirmer, Cedric-
dc.description.abstractIn the pharmaceutical industry, pumps are most often used for fluid transfer in upstream and downstream processing steps. As an alternative to the membrane or peristaltic pumps, Levitronix® GmbH has developed pulsation-free and bearingless centrifugal pumps with replaceable plastic pump heads that prevent leakage and extend the range of applications of disposable pumps to higher flow rates. However, as the application of pumps for biological and shear sensitive liquids can be very critical, the suitability must be proven. Especially in downstream processing, the evaluation of the mechanical stress on proteins is particularly relevant. To investigate the influence of different pump types on protein quality at different flow rates and pressures, chicken egg white lysozyme was chosen as model protein. Enzyme activity and particle size measurements were performed to detect changes in the protein.de_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject.ddc610.28: Biomedizin, Biomedizinische Technikde_CH
dc.subject.ddc660.6: Biotechnologiede_CH
dc.titleShear stress investigations on Levitronix single-use centrifugal pumpsde_CH
dc.typeKonferenz: Sonstigesde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.conference.detailsLevitronix Bioprocessing Conference, Live Webinar Part 2, 27 May 2020de_CH
zhaw.publication.reviewKeine Begutachtungde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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