Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: A Structural view on medicinal chemistry strategies against drug resistance
Authors: Agnello, Stefano
Brand, Michael
Chellat, Mathieu
Gazzola, Silvia
Riedl, Rainer
et. al: No
DOI: 10.1002/anie.201802416
Published in: Angewandte Chemie
Volume(Issue): 58
Issue: 11
Page(s): 3300
Pages to: 3345
Issue Date: 30-May-2018
Publisher / Ed. Institution: Wiley
ISSN: 0044-8249
Language: English
Subjects: Drug discovery; Drug resistance; Medicinal chemistry; Structure-activity relationships; Structure-based drug design; Animals; Anti-HIV Agents; Anti-infective agents; Antimalarials; Antineoplastic agents; Drug design; Humans; Molecular models; Molecular structure; Protein binding; Signal transduction
Subject (DDC): 615: Pharmacology and therapeutics
Abstract: The natural phenomenon of drug resistance is a widespread issue that hampers the performance of drugs in many major clinical indications. Antibacterial and antifungal drugs are affected, as well as compounds for the treatment of cancer, viral infections, or parasitic diseases. Despite the very diverse set of biological targets and organisms involved in the development of drug resistance, the underlying molecular mechanisms have been identified to understand the emergence of resistance and to overcome this detrimental process. Detailed structural information on the root causes for drug resistance is nowadays frequently available, so next-generation drugs can be designed that are anticipated to suffer less from resistance. This knowledge-based approach is essential for fighting the inevitable occurrence of drug resistance.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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