|Publication type:||Article in scientific journal|
|Type of review:||Peer review (publication)|
|Title:||A Structural view on medicinal chemistry strategies against drug resistance|
|Published in:||Angewandte Chemie|
|Publisher / Ed. Institution:||Wiley|
|Subjects:||Drug discovery; Drug resistance; Medicinal chemistry; Structure-activity relationships; Structure-based drug design; Animals; Anti-HIV Agents; Anti-infective agents; Antimalarials; Antineoplastic agents; Drug design; Humans; Molecular models; Molecular structure; Protein binding; Signal transduction|
|Subject (DDC):||615: Pharmacology and therapeutics|
|Abstract:||The natural phenomenon of drug resistance is a widespread issue that hampers the performance of drugs in many major clinical indications. Antibacterial and antifungal drugs are affected, as well as compounds for the treatment of cancer, viral infections, or parasitic diseases. Despite the very diverse set of biological targets and organisms involved in the development of drug resistance, the underlying molecular mechanisms have been identified to understand the emergence of resistance and to overcome this detrimental process. Detailed structural information on the root causes for drug resistance is nowadays frequently available, so next-generation drugs can be designed that are anticipated to suffer less from resistance. This knowledge-based approach is essential for fighting the inevitable occurrence of drug resistance.|
|Fulltext version:||Published version|
|License (according to publishing contract):||Licence according to publishing contract|
|Departement:||Life Sciences and Facility Management|
|Organisational Unit:||Institute of Chemistry and Biotechnology (ICBT)|
|Appears in collections:||Publikationen Life Sciences und Facility Management|
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