Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods

Löffelholz, Christian; Husemann, Ute; Greller, Gerhard; Meusel, Wolfram; Kauling, Jörg; Ay, Peter; Kraume, Matthias; Eibl-Schindler, Regine; Eibl, Dieter

doi:10.1002/cite.201200125

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods
Authors:	Löffelholz, Christian Husemann, Ute Greller, Gerhard Meusel, Wolfram Kauling, Jörg Ay, Peter Kraume, Matthias Eibl-Schindler, Regine Eibl, Dieter
DOI:	10.1002/cite.201200125
Published in:	Chemie Ingenieur Technik
Volume(Issue):	85
Issue:	1-2
Page(s):	40
Pages to:	56
Issue Date:	Feb-2013
Publisher / Ed. Institution:	Wiley
Publisher / Ed. Institution:	Weinheim
ISSN:	0009-286X 1522-2640
Language:	English
Subject (DDC):	660: Chemical engineering
Abstract:	During the past five years, the number of single-use bioreactors used in biopharmaceutical research and production has increased tremendously. This increase has been particularly associated with mammalian cell culture processes from small- to medium-scale volumes. Even though nowadays customers can choose from a multitude of 2nd and 3rd generation single-use bioreactors, ranging from mL- up to m3-scale, there is a lack of knowledge of their engineering parameters. Different approaches have been applied to characterization investigations, resulting in an inability to compare different single-use bioreactors with each other and their reusable counterparts, creating an obstacle to a systematic approach to scaling-up the process. This article describes parametric, experimental and computer-based numeric methods for biochemical engineering characterization of single-use bioreactors, which have already been used successfully for the characterization of their reusable counterparts. For the first time, these methods have been evaluated in terms of their practical application.
URI:	https://digitalcollection.zhaw.ch/handle/11475/2245
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Löffelholz, C., Husemann, U., Greller, G., Meusel, W., Kauling, J., Ay, P., Kraume, M., Eibl-Schindler, R., & Eibl, D. (2013). Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods. Chemie Ingenieur Technik, 85(1-2), 40–56. https://doi.org/10.1002/cite.201200125

Löffelholz, C. et al. (2013) ‘Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods’, Chemie Ingenieur Technik, 85(1-2), pp. 40–56. Available at: https://doi.org/10.1002/cite.201200125.

C. Löffelholz et al., “Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods,” Chemie Ingenieur Technik, vol. 85, no. 1-2, pp. 40–56, Feb. 2013, doi: 10.1002/cite.201200125.

LÖFFELHOLZ, Christian, Ute HUSEMANN, Gerhard GRELLER, Wolfram MEUSEL, Jörg KAULING, Peter AY, Matthias KRAUME, Regine EIBL-SCHINDLER und Dieter EIBL, 2013. Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods. Chemie Ingenieur Technik. Februar 2013. Bd. 85, Nr. 1-2, S. 40–56. DOI 10.1002/cite.201200125

Löffelholz, Christian, Ute Husemann, Gerhard Greller, Wolfram Meusel, Jörg Kauling, Peter Ay, Matthias Kraume, Regine Eibl-Schindler, and Dieter Eibl. 2013. “Bioengineering Parameters for Single-Use Bioreactors : Overview and Evaluation of Suitable Methods.” Chemie Ingenieur Technik 85 (1-2): 40–56. https://doi.org/10.1002/cite.201200125.

Löffelholz, Christian, et al. “Bioengineering Parameters for Single-Use Bioreactors : Overview and Evaluation of Suitable Methods.” Chemie Ingenieur Technik, vol. 85, no. 1-2, Feb. 2013, pp. 40–56, https://doi.org/10.1002/cite.201200125.