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dc.contributor.authorEibl-Schindler, Regine-
dc.contributor.authorSteiger, Nina-
dc.contributor.authorWellnitz, Sabine-
dc.contributor.authorVicente, Tiago-
dc.contributor.authorJohn, Corinne-
dc.contributor.authorEibl, Dieter-
dc.date.accessioned2018-01-29T15:11:51Z-
dc.date.available2018-01-29T15:11:51Z-
dc.date.issued2014-
dc.identifier.isbn978-3-642-45157-7de_CH
dc.identifier.isbn978-3-642-45158-4de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/2254-
dc.description.abstractDuring the last few years virus like particles (VLPs) have become increasingly interesting for the production of vaccines. This development is explained by their excellent safety profile as well as a significant number of clinical studies showing strong and long-lasting protection. A further reason is the possibility of speeding up VLP vaccine manufacturing by implementing single-use (SU) technology in the case of mammalian and insect-cell-based processes, for which a multitude of SU devices up to middle-volume scale already exist. After briefly introducing the vaccine types and expression systems currently in use, this chapter turns to VLP vaccines and the insect cell/baculovirus expression vector system (IC/BEVS). Based on the main process characteristics and typical process flow of IC/BEVS-based VLP vaccine productions, suitable SU devices and their implementation are addressed. We subsequently report on the successful development of a fast, scalable benchtop production process generating a four-protein component influenza A H1N1 VLP vaccine candidate. This process is based on Spodoptera frugiperda (Sf)-9 cells and combines Redbiotec’s rePAXTM technology with obtainable SU devices for upstream (USP) and downstream processing (DSP).de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofDisposable bioreactors IIde_CH
dc.relation.ispartofseriesAdvances in Biochemical Engineering/Biotechnologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectDSPde_CH
dc.subjectInfluenzade_CH
dc.subjectVLP vaccinede_CH
dc.subjectSf-9/BEVS USPde_CH
dc.subjectWave-mixed bioreactorde_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.titleFast single-use VLP vaccine productions based on insect cells and the baculovirus expression vector system : influenza as case studyde_CH
dc.typeBuchbeitragde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.publisher.placeBerlinde_CH
dc.identifier.doi10.1007/10_2013_186de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end125de_CH
zhaw.pages.start99de_CH
zhaw.parentwork.editorEibl, Dieter-
zhaw.parentwork.editorEibl-Schindler, Regine-
zhaw.publication.statuspublishedVersionde_CH
zhaw.series.number138de_CH
zhaw.publication.reviewEditorial reviewde_CH
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Eibl-Schindler, R., Steiger, N., Wellnitz, S., Vicente, T., John, C., & Eibl, D. (2014). Fast single-use VLP vaccine productions based on insect cells and the baculovirus expression vector system : influenza as case study. In D. Eibl & R. Eibl-Schindler (Eds.), Disposable bioreactors II (pp. 99–125). Springer. https://doi.org/10.1007/10_2013_186
Eibl-Schindler, R. et al. (2014) ‘Fast single-use VLP vaccine productions based on insect cells and the baculovirus expression vector system : influenza as case study’, in D. Eibl and R. Eibl-Schindler (eds) Disposable bioreactors II. Berlin: Springer, pp. 99–125. Available at: https://doi.org/10.1007/10_2013_186.
R. Eibl-Schindler, N. Steiger, S. Wellnitz, T. Vicente, C. John, and D. Eibl, “Fast single-use VLP vaccine productions based on insect cells and the baculovirus expression vector system : influenza as case study,” in Disposable bioreactors II, D. Eibl and R. Eibl-Schindler, Eds. Berlin: Springer, 2014, pp. 99–125. doi: 10.1007/10_2013_186.
EIBL-SCHINDLER, Regine, Nina STEIGER, Sabine WELLNITZ, Tiago VICENTE, Corinne JOHN und Dieter EIBL, 2014. Fast single-use VLP vaccine productions based on insect cells and the baculovirus expression vector system : influenza as case study. In: Dieter EIBL und Regine EIBL-SCHINDLER (Hrsg.), Disposable bioreactors II. Berlin: Springer. S. 99–125. ISBN 978-3-642-45157-7
Eibl-Schindler, Regine, Nina Steiger, Sabine Wellnitz, Tiago Vicente, Corinne John, and Dieter Eibl. 2014. “Fast Single-Use VLP Vaccine Productions Based on Insect Cells and the Baculovirus Expression Vector System : Influenza as Case Study.” In Disposable Bioreactors II, edited by Dieter Eibl and Regine Eibl-Schindler, 99–125. Berlin: Springer. https://doi.org/10.1007/10_2013_186.
Eibl-Schindler, Regine, et al. “Fast Single-Use VLP Vaccine Productions Based on Insect Cells and the Baculovirus Expression Vector System : Influenza as Case Study.” Disposable Bioreactors II, edited by Dieter Eibl and Regine Eibl-Schindler, Springer, 2014, pp. 99–125, https://doi.org/10.1007/10_2013_186.


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