A cost-effective and reliable method to predict mechanical stress in single-use and standard pumps

Dittler, Ina; Kaiser, Stephan; Blaschczok, Katharina; Löffelholz, Christian; Bösch, Pascal; Dornfeld, Wolfgang; Schöb, Reto; Rojahn, Jürgen; Kraume, Matthias; Eibl, Dieter

doi:10.1002/elsc.201300068

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	A cost-effective and reliable method to predict mechanical stress in single-use and standard pumps
Authors:	Dittler, Ina Kaiser, Stephan Blaschczok, Katharina Löffelholz, Christian Bösch, Pascal Dornfeld, Wolfgang Schöb, Reto Rojahn, Jürgen Kraume, Matthias Eibl, Dieter
DOI:	10.1002/elsc.201300068
Published in:	Engineering in Life Sciences
Volume(Issue):	14
Issue:	3
Page(s):	311
Pages to:	317
Issue Date:	May-2014
Publisher / Ed. Institution:	Wiley
Publisher / Ed. Institution:	Weinheim
ISSN:	1618-0240 1618-2863
Language:	English
Subject (DDC):	620: Engineering
Abstract:	The suitability of oil-water emulsions to predict shear forces in stirred bioreactors under cost-effective and time-saving conditions has been demonstrated several times, but no application to pumps has been described so far. In this report, the drop sizes in a model oil-water system were determined for the Levitronix PuraLev® MU series (PuraLev® 200MU and PuraLev® 600MU), a peristaltic pump (Masterflex® I/P Easy Load), and a 4-piston diaphragm pump (Quattroflow 1200-SU) using inline endoscopy. It was determined that the Sauter mean diameter could be used as a comparison criterion to estimate mechanical stress in pumps. The investigation showed that PuraLev® MU pumps are characterized by up to 59 % larger Sauter mean diameters than their counterparts at comparable operational conditions. This indicates lower hydrodynamic stress in the PuraLev® MU pumps. Using computational fluid dynamics (CFD), a well-streamlined fluid flow and low turbulent energy dissipation rates (TEDR) were found in the PuraLev® MU pumps, which correlated well with experimental results. A calculation model was used to predict the Sauter mean diameter by combining both experimental and CFD data. Good agreement with deviations below 13% was determined between model predictions and experimental data.
URI:	https://digitalcollection.zhaw.ch/handle/11475/2344
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Dittler, I., Kaiser, S., Blaschczok, K., Löffelholz, C., Bösch, P., Dornfeld, W., Schöb, R., Rojahn, J., Kraume, M., & Eibl, D. (2014). A cost-effective and reliable method to predict mechanical stress in single-use and standard pumps. Engineering in Life Sciences, 14(3), 311–317. https://doi.org/10.1002/elsc.201300068

Dittler, I. et al. (2014) ‘A cost-effective and reliable method to predict mechanical stress in single-use and standard pumps’, Engineering in Life Sciences, 14(3), pp. 311–317. Available at: https://doi.org/10.1002/elsc.201300068.

I. Dittler et al., “A cost-effective and reliable method to predict mechanical stress in single-use and standard pumps,” Engineering in Life Sciences, vol. 14, no. 3, pp. 311–317, May 2014, doi: 10.1002/elsc.201300068.

DITTLER, Ina, Stephan KAISER, Katharina BLASCHCZOK, Christian LÖFFELHOLZ, Pascal BÖSCH, Wolfgang DORNFELD, Reto SCHÖB, Jürgen ROJAHN, Matthias KRAUME und Dieter EIBL, 2014. A cost-effective and reliable method to predict mechanical stress in single-use and standard pumps. Engineering in Life Sciences. Mai 2014. Bd. 14, Nr. 3, S. 311–317. DOI 10.1002/elsc.201300068

Dittler, Ina, Stephan Kaiser, Katharina Blaschczok, Christian Löffelholz, Pascal Bösch, Wolfgang Dornfeld, Reto Schöb, Jürgen Rojahn, Matthias Kraume, and Dieter Eibl. 2014. “A Cost-Effective and Reliable Method to Predict Mechanical Stress in Single-Use and Standard Pumps.” Engineering in Life Sciences 14 (3): 311–17. https://doi.org/10.1002/elsc.201300068.

Dittler, Ina, et al. “A Cost-Effective and Reliable Method to Predict Mechanical Stress in Single-Use and Standard Pumps.” Engineering in Life Sciences, vol. 14, no. 3, May 2014, pp. 311–17, https://doi.org/10.1002/elsc.201300068.