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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-24638
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dc.contributor.authorSalikhanov, Islam-
dc.contributor.authorHeinimann, Karl-
dc.contributor.authorChappuis, Pierre-
dc.contributor.authorBuerki, Nicole-
dc.contributor.authorGraffeo, Rossella-
dc.contributor.authorHeinzelmann, Viola-
dc.contributor.authorRabaglio, Manuela-
dc.contributor.authorTaborelli, Monica-
dc.contributor.authorWieser, Simon-
dc.contributor.authorKatapodi, Maria C.-
dc.date.accessioned2022-03-18T09:25:07Z-
dc.date.available2022-03-18T09:25:07Z-
dc.date.issued2021-11-15-
dc.identifier.issn0022-2593de_CH
dc.identifier.issn1468-6244de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/24638-
dc.description.abstractBackground: We estimated the cost-effectiveness of universal DNA screening for Lynch syndrome (LS) among newly diagnosed patients with colorectal cancer (CRC) followed by cascade screening of relatives from the Swiss healthcare system perspective. Methods: We integrated decision trees with Markov models to calculate incremental cost per quality-adjusted life-year saved by screening all patients with CRC (alternative strategy) compared with CRC tumour-based testing followed by DNA sequencing (current strategy). Results: The alternative strategy has an incremental cost-effectiveness ratio of CHF65 058 compared with the current strategy, which is cost-effective according to Swiss standards. Based on annual incidence of CRC in Switzerland, universal DNA screening correctly identifies all 123 patients with CRC with LS, prevents 17 LS deaths and avoids 19 CRC cases, while the current strategy leads to 32 false negative results and 253 LS cases lost to follow-up. One way and probabilistic sensitivity analyses showed that universal DNA testing is cost-effective in around 80% of scenarios, and that the cost of DNA testing and the number of invited relatives per LS case determine the cost-effectiveness ratio. Conclusion: Results can inform policymakers, healthcare providers and insurance companies about the costs and benefits associated with universal screening for LS and cascade genetic testing of relatives.de_CH
dc.language.isoende_CH
dc.publisherBMJ Publishing Groupde_CH
dc.relation.ispartofJournal of Medical Geneticsde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectCost and cost analysisde_CH
dc.subjectGastrointestinal diseasede_CH
dc.subjectGenetic counselingde_CH
dc.subjectGenetic testingde_CH
dc.subjectHealth care economic and organizationde_CH
dc.subject.ddc362.1041: Gesundheitsökonomiede_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleSwiss cost-effectiveness analysis of universal screening for Lynch syndrome of patients with colorectal cancer followed by cascade genetic testing of relativesde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Management and Lawde_CH
zhaw.organisationalunitWinterthurer Institut für Gesundheitsökonomie (WIG)de_CH
dc.identifier.doi10.1136/jmedgenet-2021-108062de_CH
dc.identifier.doi10.21256/zhaw-24638-
dc.identifier.pmid34782441de_CH
zhaw.funding.euNode_CH
zhaw.issue9de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end930de_CH
zhaw.pages.start924de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume59de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Salikhanov, I., Heinimann, K., Chappuis, P., Buerki, N., Graffeo, R., Heinzelmann, V., Rabaglio, M., Taborelli, M., Wieser, S., & Katapodi, M. C. (2021). Swiss cost-effectiveness analysis of universal screening for Lynch syndrome of patients with colorectal cancer followed by cascade genetic testing of relatives. Journal of Medical Genetics, 59(9), 924–930. https://doi.org/10.1136/jmedgenet-2021-108062
Salikhanov, I. et al. (2021) ‘Swiss cost-effectiveness analysis of universal screening for Lynch syndrome of patients with colorectal cancer followed by cascade genetic testing of relatives’, Journal of Medical Genetics, 59(9), pp. 924–930. Available at: https://doi.org/10.1136/jmedgenet-2021-108062.
I. Salikhanov et al., “Swiss cost-effectiveness analysis of universal screening for Lynch syndrome of patients with colorectal cancer followed by cascade genetic testing of relatives,” Journal of Medical Genetics, vol. 59, no. 9, pp. 924–930, Nov. 2021, doi: 10.1136/jmedgenet-2021-108062.
SALIKHANOV, Islam, Karl HEINIMANN, Pierre CHAPPUIS, Nicole BUERKI, Rossella GRAFFEO, Viola HEINZELMANN, Manuela RABAGLIO, Monica TABORELLI, Simon WIESER und Maria C. KATAPODI, 2021. Swiss cost-effectiveness analysis of universal screening for Lynch syndrome of patients with colorectal cancer followed by cascade genetic testing of relatives. Journal of Medical Genetics. 15 November 2021. Bd. 59, Nr. 9, S. 924–930. DOI 10.1136/jmedgenet-2021-108062
Salikhanov, Islam, Karl Heinimann, Pierre Chappuis, Nicole Buerki, Rossella Graffeo, Viola Heinzelmann, Manuela Rabaglio, Monica Taborelli, Simon Wieser, and Maria C. Katapodi. 2021. “Swiss Cost-Effectiveness Analysis of Universal Screening for Lynch Syndrome of Patients with Colorectal Cancer Followed by Cascade Genetic Testing of Relatives.” Journal of Medical Genetics 59 (9): 924–30. https://doi.org/10.1136/jmedgenet-2021-108062.
Salikhanov, Islam, et al. “Swiss Cost-Effectiveness Analysis of Universal Screening for Lynch Syndrome of Patients with Colorectal Cancer Followed by Cascade Genetic Testing of Relatives.” Journal of Medical Genetics, vol. 59, no. 9, Nov. 2021, pp. 924–30, https://doi.org/10.1136/jmedgenet-2021-108062.


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