Lymphopenia is highly prevalent in overt myelofibrosis at diagnosis but lacks additional prognostic value

Messerich, N.-M.; Cogliatti, S.; Lehmann, T.; Holbro, L.; Graf, R.; Benz, R.; Volken, T.; Silzle, T.

Publication type:	Conference other
Type of review:	Peer review (abstract)
Title:	Lymphopenia is highly prevalent in overt myelofibrosis at diagnosis but lacks additional prognostic value
Authors:	Messerich, N.-M. Cogliatti, S. Lehmann, T. Holbro, L. Graf, R. Benz, R. Volken, T. Silzle, T.
et. al:	No
Published in:	Swiss Medical Weekly
Proceedings:	Abstracts of the Swiss Oncology & Hematology Congress (SOHC)
Volume(Issue):	151
Issue:	Suppl. 255
Page(s):	32
Pages to:	33
Conference details:	Swiss Oncology & Hematology Congress (SOHC), Zurich Airport, 18-20 November 2021
Issue Date:	18-Nov-2021
Publisher / Ed. Institution:	EMH Swiss Medical Publishers
ISSN:	1424-7860
Language:	English
Subjects:	Lymphopenia; Myelofibrosis
Subject (DDC):	616: Internal medicine and diseases
Abstract:	Background: Lymphopenia is prognostically relevant in several malignancies. Little is known about its role in myelofibrosis (MF). Aim: To evaluate the prevalence of lymphopenia at diagnosis and its prognostic impact in MF. Methods: Patients diagnosed between 2010-2020 at the Cantonal Hospitals St. Gallen and Muensterlingen with primary MF [PMF], MF secondary to essential thrombocytopenia or polycythemia vera [MF- post] and prefibrotic primary MF [pre- PMF] were evaluated for the absolute lymphocyte count (ALC) at diagnosis. Results: 80 patients with overt MF (PMF n = 59, MF-post n = 21) and 28 with pre-PMF were included. The ALC was lower in overt MF compared to pre-PMF (median 1.5x109/l versus 2.0x109/l, p = 0.039). In MF-post (evaluable post-ET n = 8, post-PV n = 10), a drop of the ALC was documented at MF-diagnosis compared to the diagnosis of the preceeding disorder (median 1.35x109/l versus 2.05x109/l, p = 0.009). An ALC <1.5x109/l was associated with lower hemoglobin concentration and neutrophil-counts (median 100 vs. 115g/l and 5.5 vs. 8 G/l, p = 0.009 and p = 0.023). For cases with fibrosis grade 3 versus grade 2, a trend towards a lower ALC was noted (median 1.3x109/l versus 1.6x109/l, p = 0.07). The DIPSS-groups did not differ with regard to the ALC. Neither an ALC <1.0x109/l nor <1.5x1.0x109/l was associated with a survival difference (median 65 versus 73 months, p = 0.879 and 66 versus 89 months, p = 0.823). Conclusions: Lymphopenia in MF is highly prevalent at diagnosis, but offers no additional prognostic information. Its association with lower hemoglobin values and the development of fibrosis in cases of MF-post points towards a possible relationship of lymphopenia with MF-pathophysiology.
URI:	https://smw.ch/article/doi/SMW.2021.w30107 https://digitalcollection.zhaw.ch/handle/11475/24896
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	School of Health Sciences
Organisational Unit:	Institute of Public Health (IPH)
Appears in collections:	Publikationen Gesundheit

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Messerich, N.-M., Cogliatti, S., Lehmann, T., Holbro, L., Graf, R., Benz, R., Volken, T., & Silzle, T. (2021). Lymphopenia is highly prevalent in overt myelofibrosis at diagnosis but lacks additional prognostic value [Conference presentation]. Swiss Medical Weekly, 151(Suppl. 255), 32–33. https://smw.ch/article/doi/SMW.2021.w30107

Messerich, N.-M. et al. (2021) ‘Lymphopenia is highly prevalent in overt myelofibrosis at diagnosis but lacks additional prognostic value’, in Swiss Medical Weekly. EMH Swiss Medical Publishers, pp. 32–33. Available at: https://smw.ch/article/doi/SMW.2021.w30107.

N.-M. Messerich et al., “Lymphopenia is highly prevalent in overt myelofibrosis at diagnosis but lacks additional prognostic value,” in Swiss Medical Weekly, Nov. 2021, vol. 151, no. Suppl. 255, pp. 32–33. [Online]. Available: https://smw.ch/article/doi/SMW.2021.w30107

MESSERICH, N.-M., S. COGLIATTI, T. LEHMANN, L. HOLBRO, R. GRAF, R. BENZ, T. VOLKEN und T. SILZLE, 2021. Lymphopenia is highly prevalent in overt myelofibrosis at diagnosis but lacks additional prognostic value. In: Swiss Medical Weekly [online]. Conference presentation. EMH Swiss Medical Publishers. 18 November 2021. S. 32–33. Verfügbar unter: https://smw.ch/article/doi/SMW.2021.w30107

Messerich, N.-M., S. Cogliatti, T. Lehmann, L. Holbro, R. Graf, R. Benz, T. Volken, and T. Silzle. 2021. “Lymphopenia Is Highly Prevalent in Overt Myelofibrosis at Diagnosis but Lacks Additional Prognostic Value.” Conference presentation. In Swiss Medical Weekly, 151:32–33. EMH Swiss Medical Publishers. https://smw.ch/article/doi/SMW.2021.w30107.

Messerich, N.-M., et al. “Lymphopenia Is Highly Prevalent in Overt Myelofibrosis at Diagnosis but Lacks Additional Prognostic Value.” Swiss Medical Weekly, vol. 151, no. Suppl. 255, EMH Swiss Medical Publishers, 2021, pp. 32–33, https://smw.ch/article/doi/SMW.2021.w30107.