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https://doi.org/10.21256/zhaw-25589| Publication type: | Conference paper |
| Type of review: | Peer review (publication) |
| Title: | Portable multi-wavelength fluorescence measurement device |
| Authors: | Hagen, Raphael Fehr, Daniel Spano, Fabrizio Brambilla, Davide Bonmarin, Mathias |
| et. al: | No |
| DOI: | 10.1109/MeMeA54994.2022.9856591 10.21256/zhaw-25589 |
| Proceedings: | 2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA) |
| Conference details: | XVII IEEE International Symposium on Medical Measurements and Applications, Messina, Italy, 22-24 June 2022 |
| Issue Date: | 2022 |
| Publisher / Ed. Institution: | IEEE |
| ISBN: | 978-1-6654-8299-8 |
| Language: | English |
| Subject (DDC): | 610.28: Biomedicine, biomedical engineering |
| Abstract: | Monitoring-based preventive medicine relies heavily on minimal or noninvasive, portable and cost-effective measurement solutions. This work presents a portable multi-wavelength fluorescence measurement system. The pinhole collimator, Fresnel focusing lens and PIN photo diode provide a cost-effective fluorescent light detection path. The with matte black filament 3D printed housing reduces unwanted reflections along the detection path. The integrated laser diode drivers ensure constant optical output power during operation. This is achieved by utilizing a laser diode package which incorporates both a laser and monitor diode. The monitor diode's output photocurrent is proportional to the optical output power, and thus provides, a feedback path for the driver. An optical diffuser is pre-mounted on each laser diode, providing a uniform illumination of the measurement area. The device adapts to a wide variety of fluorescent dyes by offering exchangeable laser diode modules and support of standard-sized optical thin film filters. The precision integrator transimpedance amplifier applies a switched-input photocurrent measurement technique that ensures the level of sensitivity required for clinical usage. Experimental validation indicates sensitivity in the pico-ampere range. Ex vivo and in vivo measurements, performed by the Faculty of Pharmacy at the Université de Montréal, confirm that the instrument matches its intended application. |
| Further description: | © 2022 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/25589 |
| Fulltext version: | Accepted version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | School of Engineering |
| Organisational Unit: | Institute of Computational Physics (ICP) |
| Appears in collections: | Publikationen School of Engineering |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2022_Hagen-etal_Portable-multi-wavelength-fluoresence-measurement-device.pdf | Accepted Version | 7.56 MB | Adobe PDF |  View/Open |
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Hagen, R., Fehr, D., Spano, F., Brambilla, D., & Bonmarin, M. (2022). Portable multi-wavelength fluorescence measurement device. 2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA). https://doi.org/10.1109/MeMeA54994.2022.9856591
Hagen, R. et al. (2022) ‘Portable multi-wavelength fluorescence measurement device’, in 2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA). IEEE. Available at: https://doi.org/10.1109/MeMeA54994.2022.9856591.
R. Hagen, D. Fehr, F. Spano, D. Brambilla, and M. Bonmarin, “Portable multi-wavelength fluorescence measurement device,” in 2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA), 2022. doi: 10.1109/MeMeA54994.2022.9856591.
HAGEN, Raphael, Daniel FEHR, Fabrizio SPANO, Davide BRAMBILLA und Mathias BONMARIN, 2022. Portable multi-wavelength fluorescence measurement device. In: 2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA). Conference paper. IEEE. 2022. ISBN 978-1-6654-8299-8
Hagen, Raphael, Daniel Fehr, Fabrizio Spano, Davide Brambilla, and Mathias Bonmarin. 2022. “Portable Multi-Wavelength Fluorescence Measurement Device.” Conference paper. In 2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA). IEEE. https://doi.org/10.1109/MeMeA54994.2022.9856591.
Hagen, Raphael, et al. “Portable Multi-Wavelength Fluorescence Measurement Device.” 2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA), IEEE, 2022, https://doi.org/10.1109/MeMeA54994.2022.9856591.
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