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https://doi.org/10.21256/zhaw-1661| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | The MATCHIT automaton : exploiting compartmentalization for the synthesis of branched polymers |
| Authors: | Weyland, Mathias S. Fellermann, Harold Hadorn, Maik Sorek, Daniel Lancet, Doron Rasmussen, Steen Füchslin, Rudolf Marcel |
| DOI: | 10.21256/zhaw-1661 10.1155/2013/467428 |
| Published in: | Computational and Mathematical Methods in Medicine |
| Volume(Issue): | 2013 |
| Issue: | 467428 |
| Issue Date: | 2013 |
| Publisher / Ed. Institution: | Hindawi |
| ISSN: | 1748-670X 1748-6718 |
| Language: | English |
| Subject (DDC): | 005: Computer programming, programs and data 540: Chemistry |
| Abstract: | We propose an automaton, a theoretical framework that demonstrates how to improve the yield of the synthesis of branched chemical polymer reactions. This is achieved by separating substeps of the path of synthesis into compartments. We use chemical containers (chemtainers) to carry the substances through a sequence of fixed successive compartments. We describe the automaton in mathematical terms and show how it can be configured automatically in order to synthesize a given branched polymer target. The algorithm we present finds an optimal path of synthesis in linear time. We discuss how the automaton models compartmentalized structures found in cells, such as the endoplasmic reticulum and the Golgi apparatus, and we show how this compartmentalization can be exploited for the synthesis of branched polymers such as oligosaccharides. Lastly, we show examples of artificial branched polymers and discuss how the automaton can be configured to synthesize them with maximal yield. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2801 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY 3.0: Attribution 3.0 Unported |
| Departement: | School of Engineering |
| Organisational Unit: | Institute of Applied Mathematics and Physics (IAMP) |
| Appears in collections: | Publikationen School of Engineering |
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|---|---|---|---|---|
| 2013_Weyland_The MATCHIT automaton_Computational and Mathematical Methods in Medicine.pdf | 1.41 MB | Adobe PDF |  View/Open |
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Weyland, M. S., Fellermann, H., Hadorn, M., Sorek, D., Lancet, D., Rasmussen, S., & Füchslin, R. M. (2013). The MATCHIT automaton : exploiting compartmentalization for the synthesis of branched polymers. Computational and Mathematical Methods in Medicine, 2013(467428). https://doi.org/10.21256/zhaw-1661
Weyland, M.S. et al. (2013) ‘The MATCHIT automaton : exploiting compartmentalization for the synthesis of branched polymers’, Computational and Mathematical Methods in Medicine, 2013(467428). Available at: https://doi.org/10.21256/zhaw-1661.
M. S. Weyland et al., “The MATCHIT automaton : exploiting compartmentalization for the synthesis of branched polymers,” Computational and Mathematical Methods in Medicine, vol. 2013, no. 467428, 2013, doi: 10.21256/zhaw-1661.
WEYLAND, Mathias S., Harold FELLERMANN, Maik HADORN, Daniel SOREK, Doron LANCET, Steen RASMUSSEN und Rudolf Marcel FÜCHSLIN, 2013. The MATCHIT automaton : exploiting compartmentalization for the synthesis of branched polymers. Computational and Mathematical Methods in Medicine. 2013. Bd. 2013, Nr. 467428. DOI 10.21256/zhaw-1661
Weyland, Mathias S., Harold Fellermann, Maik Hadorn, Daniel Sorek, Doron Lancet, Steen Rasmussen, and Rudolf Marcel Füchslin. 2013. “The MATCHIT Automaton : Exploiting Compartmentalization for the Synthesis of Branched Polymers.” Computational and Mathematical Methods in Medicine 2013 (467428). https://doi.org/10.21256/zhaw-1661.
Weyland, Mathias S., et al. “The MATCHIT Automaton : Exploiting Compartmentalization for the Synthesis of Branched Polymers.” Computational and Mathematical Methods in Medicine, vol. 2013, no. 467428, 2013, https://doi.org/10.21256/zhaw-1661.
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