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https://doi.org/10.21256/zhaw-1686| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors |
| Authors: | Fischer, Thomas Riedl, Rainer |
| DOI: | 10.1002/cmdc.201300278 10.21256/zhaw-1686 |
| Published in: | ChemMedChem |
| Volume(Issue): | 8 |
| Issue: | 9 |
| Page(s): | 1457 |
| Pages to: | 1461 |
| Issue Date: | 2013 |
| Publisher / Ed. Institution: | Wiley |
| ISSN: | 1860-7187 1860-7179 |
| Language: | English |
| Subjects: | Water-mediated interactions; Medicinal chemistry; Chemical biology; Structure-based design |
| Subject (DDC): | 572: Biochemistry |
| Abstract: | Water in the architecture of life: Potent and selective matrix metalloproteinase-13 (MMP-13) inhibitors were rationally designed by targeting multiple water-mediated interactions between the target protein and small-molecule inhibitors. This structure-based design concept offers tremendous opportunities for the discovery of unique small molecules with tailored biological activity. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2865 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY-NC 3.0: Attribution - Non commercial 3.0 Unported |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 2013_Fischer_Strategic targeting of multiple water-mediated interactions_ChemMedChem.pdf | 1.29 MB | Adobe PDF |  View/Open |
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Fischer, T., & Riedl, R. (2013). Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors. ChemMedChem, 8(9), 1457–1461. https://doi.org/10.1002/cmdc.201300278
Fischer, T. and Riedl, R. (2013) ‘Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors’, ChemMedChem, 8(9), pp. 1457–1461. Available at: https://doi.org/10.1002/cmdc.201300278.
T. Fischer and R. Riedl, “Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors,” ChemMedChem, vol. 8, no. 9, pp. 1457–1461, 2013, doi: 10.1002/cmdc.201300278.
FISCHER, Thomas und Rainer RIEDL, 2013. Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors. ChemMedChem. 2013. Bd. 8, Nr. 9, S. 1457–1461. DOI 10.1002/cmdc.201300278
Fischer, Thomas, and Rainer Riedl. 2013. “Strategic Targeting of Multiple Water-Mediated Interactions : A Concise and Rational Structure-Based Design Approach to Potent and Selective MMP-13 Inhibitors.” ChemMedChem 8 (9): 1457–61. https://doi.org/10.1002/cmdc.201300278.
Fischer, Thomas, and Rainer Riedl. “Strategic Targeting of Multiple Water-Mediated Interactions : A Concise and Rational Structure-Based Design Approach to Potent and Selective MMP-13 Inhibitors.” ChemMedChem, vol. 8, no. 9, 2013, pp. 1457–61, https://doi.org/10.1002/cmdc.201300278.
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