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  2. School of Management and Law
  3. Publikationen
  4. Publikationen School of Management and Law
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dc.contributor.authorEichler, Klaus-
dc.contributor.authorPuhan, Milo A.-
dc.contributor.authorBachmann, Lucas M.-
dc.date.accessioned2018-08-24T11:20:36Z-
dc.date.available2018-08-24T11:20:36Z-
dc.date.issued2007-
dc.identifier.issn0003-9926de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/9607-
dc.description.abstractGuidance on statin provision in patients without cardiovascular disease is of great practical importance. In recent years, several publications emerged showing conflicting results. The systematic review by Thavendiranathan et al. is timely and covers a relevant issue but not without limitations. We have 3 observations. First, this review enrolled moderate- and high-risk patients (average extrapolated 10-year coronary risk, 13%) despite the fact that greater than 80% of the US population who are free of cardiovascular disease do not fall into this risk category. No direct conclusions of the effects in this large group can therefore be made. Second, it is unclear how the authors reached the conclusion that “reductions in the risk of major coronary events from statin therapy were significantly associated with greater absolute baseline coronary artery disease risk.” We were unable to reproduce this finding when repeating analyses using the data presented in Tables 1 and 2 in the review by Thavendiranathan et al. We constructed a forest plot sorted for increasing baseline risk of the primary studies showing an inverse association. A greater (relative) benefit from statin therapy was significantly associated with smaller absolute baseline risk for major coronary events (P = .04). Third, regarding the number-needed-to-treat analyses, it seems inconsistent that the authors assumed the effects of statins to be constant across risk groups, an assumption contradictory to their metaregression analysis.de_CH
dc.language.isoende_CH
dc.publisherAmerican Medical Associationde_CH
dc.relation.ispartofArchives of Internal Medicinede_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectCardiovascular diseasede_CH
dc.subjectHumande_CH
dc.subjectHydroxymethylglutaryl-CoA reductase inhibitorsde_CH
dc.subjectPreventionde_CH
dc.subjectStatinsde_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleThe role of statins in primary pevention of cardiovascular diseasede_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Management and Lawde_CH
zhaw.organisationalunitWinterthurer Institut für Gesundheitsökonomie (WIG)de_CH
dc.identifier.doi10.1001/archinte.167.10.1100-ade_CH
dc.identifier.pmid17533216de_CH
zhaw.funding.euNode_CH
zhaw.issue10de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.start1100de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume167de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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Eichler, K., Puhan, M. A., & Bachmann, L. M. (2007). The role of statins in primary pevention of cardiovascular disease. Archives of Internal Medicine, 167(10), 1100. https://doi.org/10.1001/archinte.167.10.1100-a
Eichler, K., Puhan, M.A. and Bachmann, L.M. (2007) ‘The role of statins in primary pevention of cardiovascular disease’, Archives of Internal Medicine, 167(10), p. 1100. Available at: https://doi.org/10.1001/archinte.167.10.1100-a.
K. Eichler, M. A. Puhan, and L. M. Bachmann, “The role of statins in primary pevention of cardiovascular disease,” Archives of Internal Medicine, vol. 167, no. 10, p. 1100, 2007, doi: 10.1001/archinte.167.10.1100-a.
EICHLER, Klaus, Milo A. PUHAN und Lucas M. BACHMANN, 2007. The role of statins in primary pevention of cardiovascular disease. Archives of Internal Medicine. 2007. Bd. 167, Nr. 10, S. 1100. DOI 10.1001/archinte.167.10.1100-a
Eichler, Klaus, Milo A. Puhan, and Lucas M. Bachmann. 2007. “The Role of Statins in Primary Pevention of Cardiovascular Disease.” Archives of Internal Medicine 167 (10): 1100. https://doi.org/10.1001/archinte.167.10.1100-a.
Eichler, Klaus, et al. “The Role of Statins in Primary Pevention of Cardiovascular Disease.” Archives of Internal Medicine, vol. 167, no. 10, 2007, p. 1100, https://doi.org/10.1001/archinte.167.10.1100-a.


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