De novo enzymes by computational design

Kries, Hajo; Blomberg, Rebecca; Hilvert, Donald

doi:10.1016/j.cbpa.2013.02.012

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	De novo enzymes by computational design
Authors:	Kries, Hajo Blomberg, Rebecca Hilvert, Donald
DOI:	10.1016/j.cbpa.2013.02.012
Published in:	Current Opinion in Chemical Biology
Volume(Issue):	17
Issue:	2
Page(s):	221
Pages to:	228
Issue Date:	2013
Publisher / Ed. Institution:	Elsevier
ISSN:	1367-5931 1879-0402
Language:	English
Subjects:	Algorithms; Computational biology; Directed molecular evolution; Enzymes; Protein engineering
Subject (DDC):	004: Computer science 660.6: Biotechnology
Abstract:	Computational enzyme design has emerged as a promising tool for generating made-to-order biocatalysts. In addition to improving the reliability of the design cycle, current efforts in this area are focusing on expanding the set of catalyzed reactions and investigating the structure and mechanism of individual designs. Although the activities of de novo enzymes are typically low, they can be significantly increased by directed evolution. Analysis of their evolutionary trajectories provides valuable feedback for the design algorithms and can enhance our understanding of natural protein evolution.
URI:	https://digitalcollection.zhaw.ch/handle/11475/9662
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Kries, H., Blomberg, R., & Hilvert, D. (2013). De novo enzymes by computational design. Current Opinion in Chemical Biology, 17(2), 221–228. https://doi.org/10.1016/j.cbpa.2013.02.012

Kries, H., Blomberg, R. and Hilvert, D. (2013) ‘De novo enzymes by computational design’, Current Opinion in Chemical Biology, 17(2), pp. 221–228. Available at: https://doi.org/10.1016/j.cbpa.2013.02.012.

H. Kries, R. Blomberg, and D. Hilvert, “De novo enzymes by computational design,” Current Opinion in Chemical Biology, vol. 17, no. 2, pp. 221–228, 2013, doi: 10.1016/j.cbpa.2013.02.012.

KRIES, Hajo, Rebecca BLOMBERG und Donald HILVERT, 2013. De novo enzymes by computational design. Current Opinion in Chemical Biology. 2013. Bd. 17, Nr. 2, S. 221–228. DOI 10.1016/j.cbpa.2013.02.012

Kries, Hajo, Rebecca Blomberg, and Donald Hilvert. 2013. “De Novo Enzymes by Computational Design.” Current Opinion in Chemical Biology 17 (2): 221–28. https://doi.org/10.1016/j.cbpa.2013.02.012.

Kries, Hajo, et al. “De Novo Enzymes by Computational Design.” Current Opinion in Chemical Biology, vol. 17, no. 2, 2013, pp. 221–28, https://doi.org/10.1016/j.cbpa.2013.02.012.