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dc.contributor.authorNicolescu, Rodica-
dc.contributor.authorPetcu, Cristian-
dc.contributor.authorCordeanu, Aurelia-
dc.contributor.authorFabritius, Klaus-
dc.contributor.authorSchlumpf, Margret-
dc.contributor.authorKrebs, Rolf-
dc.contributor.authorKrämer, Ursula-
dc.contributor.authorWinneke, Gerhard-
dc.date.accessioned2018-10-10T11:22:19Z-
dc.date.available2018-10-10T11:22:19Z-
dc.date.issued2010-07-
dc.identifier.issn0013-9351de_CH
dc.identifier.issn1096-0953de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/11575-
dc.description.abstractNeurobehavioral measures of attention, and clinical features of the attention-deficit hyperactivity disorder (ADHD) have been studied in pediatric environmental lead research. However rarely, if ever, have performance measures of attention or executive functions and questionnaire-based quantitative ADHD-observations been studied in the same subjects. We examined associations between pediatric blood lead concentrations (PbB), as well as those of mercury (Hg), and aluminum (Al), and performance in four different attention tasks, as well as behavioral ratings from an ICD-10 (hyperactivity) and DSM-IV-coded (attention deficit) German questionnaire (FBB-ADHS). Asymptomatic, 8-12 year old children from two Romanian cities were studied, namely Bucharest and Pantelimon, a city near a metal-processing plant. Blood was analyzed for Pb, Al, and Hg. Data from 83 children were available for final analysis. We assessed attention performance by means of four tasks of the computer-based ADHD-taylored German KITAP-battery. We also received questionnaire ratings from parents and teachers covering three ADHD-dimensions. Multiple linear regression analysis was used to estimate associations between the three neurotoxic trace metals in blood and the different ADHD features. After adjusting for eleven potentially confounding variables we found consistent borderline to significant associations between Pb, but not other metals, in blood and various performance- and questionnaire data. False alarm responses (FAR) in the KITAP subtests rather than response latencies exhibited positive associations with PbB. Questionnaire ratings for ADHD dimensions also revealed PbB-related adversity. With any two-fold increase of PbB outcome changed markedly, namely up to 35%. Restriction to children with PbBs<10mug/dl had only a marginal influence on outcome. The converging evidence from performance- and questionnaire data confirms that core elements of ADHD are adversely affected by low environmental PbB even below 10mug/dl, but not by other neurotoxic trace metals. Observed effect-sizes are considerably larger than those typically found for lead-related IQ-deficit, thus suggesting that attention deficit could be the more basic adverse effect of lead in children. This is the first study from Central and Eastern Europe dealing with links between environmental exposure of children to neurotoxic metals and ADHD.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofEnvironmental Researchde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAluminumde_CH
dc.subjectAttention deficit disorder with hyperactivityde_CH
dc.subjectEnvironmental exposurede_CH
dc.subjectEnvironmental monitoringde_CH
dc.subjectEnvironmental pollutantsde_CH
dc.subjectEpidemiological nonitoringde_CH
dc.subjectExecutive functionde_CH
dc.subjectLeadde_CH
dc.subjectMercuryde_CH
dc.subjectNervous Systemde_CH
dc.subjectRomaniade_CH
dc.subject.ddc363: Umwelt- und Sicherheitsproblemede_CH
dc.subject.ddc616.8: Neurologie und Krankheiten des Nervensystemsde_CH
dc.titleEnvironmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children : performance and questionnaire datade_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Umwelt und Natürliche Ressourcen (IUNR)de_CH
dc.identifier.doi10.1016/j.envres.2010.04.002de_CH
dc.identifier.pmid20434143de_CH
zhaw.funding.euNode_CH
zhaw.issue5de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end483de_CH
zhaw.pages.start476de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume110de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedBodenökologiede_CH
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Nicolescu, R., Petcu, C., Cordeanu, A., Fabritius, K., Schlumpf, M., Krebs, R., Krämer, U., & Winneke, G. (2010). Environmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children : performance and questionnaire data. Environmental Research, 110(5), 476–483. https://doi.org/10.1016/j.envres.2010.04.002
Nicolescu, R. et al. (2010) ‘Environmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children : performance and questionnaire data’, Environmental Research, 110(5), pp. 476–483. Available at: https://doi.org/10.1016/j.envres.2010.04.002.
R. Nicolescu et al., “Environmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children : performance and questionnaire data,” Environmental Research, vol. 110, no. 5, pp. 476–483, Jul. 2010, doi: 10.1016/j.envres.2010.04.002.
NICOLESCU, Rodica, Cristian PETCU, Aurelia CORDEANU, Klaus FABRITIUS, Margret SCHLUMPF, Rolf KREBS, Ursula KRÄMER und Gerhard WINNEKE, 2010. Environmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children : performance and questionnaire data. Environmental Research. Juli 2010. Bd. 110, Nr. 5, S. 476–483. DOI 10.1016/j.envres.2010.04.002
Nicolescu, Rodica, Cristian Petcu, Aurelia Cordeanu, Klaus Fabritius, Margret Schlumpf, Rolf Krebs, Ursula Krämer, and Gerhard Winneke. 2010. “Environmental Exposure to Lead, but Not Other Neurotoxic Metals, Relates to Core Elements of ADHD in Romanian Children : Performance and Questionnaire Data.” Environmental Research 110 (5): 476–83. https://doi.org/10.1016/j.envres.2010.04.002.
Nicolescu, Rodica, et al. “Environmental Exposure to Lead, but Not Other Neurotoxic Metals, Relates to Core Elements of ADHD in Romanian Children : Performance and Questionnaire Data.” Environmental Research, vol. 110, no. 5, July 2010, pp. 476–83, https://doi.org/10.1016/j.envres.2010.04.002.


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