Mitochondrial routing of glucose and sucrose polymers after pinocytotic uptake : avenues for drug delivery

Rashid, Rafi; Beyer, Sebastian; Blocki, Anna; Le Visage, Catherine; Trau, Dieter; Wohland, Thorsten; Raghunath, Michael

doi:10.1021/bm500243m

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Mitochondrial routing of glucose and sucrose polymers after pinocytotic uptake : avenues for drug delivery
Authors:	Rashid, Rafi Beyer, Sebastian Blocki, Anna Le Visage, Catherine Trau, Dieter Wohland, Thorsten Raghunath, Michael
DOI:	10.1021/bm500243m
Published in:	Biomacromolecules
Volume(Issue):	15
Issue:	6
Page(s):	2119
Pages to:	2127
Issue Date:	2014
Publisher / Ed. Institution:	American Chemical Society
ISSN:	1525-7797 1526-4602
Language:	English
Subject (DDC):	571: Physiology and related subjects
Abstract:	Mitochondria are key organelles organizing cellular metabolic flux. Therefore, a targeted drug delivery to mitochondria promises the advancement of medicine in fields that are associated with mitochondrial dysfunction. However, successful mitochondrial drug delivery is limited by complex transport steps across organelle membranes and fast drug efflux in cases of multidrug resistance. Strategies to deliver small-molecular-weight drugs to mitochondria are very limited, while the use of complex polymeric carriers is limited by a lack of clinical feasibility. We show here that clinically established macromolecules such as a sucrose copolymer (Ficoll 70/400 kDa) and polyglucose (dextran 70/500 kDa) are micropinocytosed swiftly by mesenchymal stem cells and subsequently routed to mitochondria. The intracellular level of Ficoll appears to decrease over time, suggesting that it does not persist within cells. After coupling to polysucrose, the low-molecular-weight photodynamic drug Rose Bengal reached mitochondria and thus exhibited an increased destructive potential after laser excitation. These findings support new opportunities to deliver already clinically approved drugs to mitochondria.
URI:	https://digitalcollection.zhaw.ch/handle/11475/12193
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

Files in This Item:

There are no files associated with this item.

Show full item record

Rashid, R., Beyer, S., Blocki, A., Le Visage, C., Trau, D., Wohland, T., & Raghunath, M. (2014). Mitochondrial routing of glucose and sucrose polymers after pinocytotic uptake : avenues for drug delivery. Biomacromolecules, 15(6), 2119–2127. https://doi.org/10.1021/bm500243m

Rashid, R. et al. (2014) ‘Mitochondrial routing of glucose and sucrose polymers after pinocytotic uptake : avenues for drug delivery’, Biomacromolecules, 15(6), pp. 2119–2127. Available at: https://doi.org/10.1021/bm500243m.

R. Rashid et al., “Mitochondrial routing of glucose and sucrose polymers after pinocytotic uptake : avenues for drug delivery,” Biomacromolecules, vol. 15, no. 6, pp. 2119–2127, 2014, doi: 10.1021/bm500243m.

RASHID, Rafi, Sebastian BEYER, Anna BLOCKI, Catherine LE VISAGE, Dieter TRAU, Thorsten WOHLAND und Michael RAGHUNATH, 2014. Mitochondrial routing of glucose and sucrose polymers after pinocytotic uptake : avenues for drug delivery. Biomacromolecules. 2014. Bd. 15, Nr. 6, S. 2119–2127. DOI 10.1021/bm500243m

Rashid, Rafi, Sebastian Beyer, Anna Blocki, Catherine Le Visage, Dieter Trau, Thorsten Wohland, and Michael Raghunath. 2014. “Mitochondrial Routing of Glucose and Sucrose Polymers after Pinocytotic Uptake : Avenues for Drug Delivery.” Biomacromolecules 15 (6): 2119–27. https://doi.org/10.1021/bm500243m.

Rashid, Rafi, et al. “Mitochondrial Routing of Glucose and Sucrose Polymers after Pinocytotic Uptake : Avenues for Drug Delivery.” Biomacromolecules, vol. 15, no. 6, 2014, pp. 2119–27, https://doi.org/10.1021/bm500243m.