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dc.contributor.authorDewavrin, Jean-Yves-
dc.contributor.authorAbdurrahiem, Muhammed-
dc.contributor.authorBlocki, Anna-
dc.contributor.authorMusib, Mrinal-
dc.contributor.authorPiazza, Francesco-
dc.contributor.authorRaghunath, Michael-
dc.date.accessioned2018-10-26T14:12:38Z-
dc.date.available2018-10-26T14:12:38Z-
dc.date.issued2015-
dc.identifier.issn1520-6106de_CH
dc.identifier.issn1520-5207de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/12196-
dc.description.abstractThe competition for access to space that arises between macromolecules is the basis of the macromolecular crowding phenomenon, known to modulate biochemical reactions in subtle ways. Crowding is a highly conserved physiological condition in and around cells in metazoans, and originates from a mixture of heterogeneous biomolecules. Here, using collagen fibrillogenesis as an experimental test platform and ideas from the theory of nonideal solutions, we show that an entropy-based synergy is created by a mixture of two different populations of artificial crowders, providing small crowders with extra volume occupancy when in the vicinity of bigger crowders. We present the physiological mechanism by which synergistic effects maximize volume exclusion with the minimum amount of heterogeneous crowders, demonstrating how the evolutionarily optimized crowded conditions found in vivo can be reproduced effectively in vitro.de_CH
dc.language.isoende_CH
dc.publisherAmerican Chemical Societyde_CH
dc.relation.ispartofJournal of Physical Chemistry Bde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject.ddc571: Physiologie und verwandte Themende_CH
dc.subject.ddc572: Biochemiede_CH
dc.titleSynergistic rate boosting of collagen fibrillogenesis in heterogeneous mixtures of crowding agentsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1021/jp5077559de_CH
zhaw.funding.euNode_CH
zhaw.issue12de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.end4358de_CH
zhaw.pages.start4350de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume119de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedMetabolic Tissue Engineeringde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Dewavrin, J.-Y., Abdurrahiem, M., Blocki, A., Musib, M., Piazza, F., & Raghunath, M. (2015). Synergistic rate boosting of collagen fibrillogenesis in heterogeneous mixtures of crowding agents. Journal of Physical Chemistry B, 119(12), 4350–4358. https://doi.org/10.1021/jp5077559
Dewavrin, J.-Y. et al. (2015) ‘Synergistic rate boosting of collagen fibrillogenesis in heterogeneous mixtures of crowding agents’, Journal of Physical Chemistry B, 119(12), pp. 4350–4358. Available at: https://doi.org/10.1021/jp5077559.
J.-Y. Dewavrin, M. Abdurrahiem, A. Blocki, M. Musib, F. Piazza, and M. Raghunath, “Synergistic rate boosting of collagen fibrillogenesis in heterogeneous mixtures of crowding agents,” Journal of Physical Chemistry B, vol. 119, no. 12, pp. 4350–4358, 2015, doi: 10.1021/jp5077559.
DEWAVRIN, Jean-Yves, Muhammed ABDURRAHIEM, Anna BLOCKI, Mrinal MUSIB, Francesco PIAZZA und Michael RAGHUNATH, 2015. Synergistic rate boosting of collagen fibrillogenesis in heterogeneous mixtures of crowding agents. Journal of Physical Chemistry B. 2015. Bd. 119, Nr. 12, S. 4350–4358. DOI 10.1021/jp5077559
Dewavrin, Jean-Yves, Muhammed Abdurrahiem, Anna Blocki, Mrinal Musib, Francesco Piazza, and Michael Raghunath. 2015. “Synergistic Rate Boosting of Collagen Fibrillogenesis in Heterogeneous Mixtures of Crowding Agents.” Journal of Physical Chemistry B 119 (12): 4350–58. https://doi.org/10.1021/jp5077559.
Dewavrin, Jean-Yves, et al. “Synergistic Rate Boosting of Collagen Fibrillogenesis in Heterogeneous Mixtures of Crowding Agents.” Journal of Physical Chemistry B, vol. 119, no. 12, 2015, pp. 4350–58, https://doi.org/10.1021/jp5077559.


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