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  4. Publikationen Life Sciences und Facility Management
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dc.contributor.authorPeh, Priscilla-
dc.contributor.authorLim, Natalie Sheng Jie-
dc.contributor.authorBlocki, Anna-
dc.contributor.authorChee, Stella Min Ling-
dc.contributor.authorPark, Heyjin Chris-
dc.contributor.authorLiao, Susan-
dc.contributor.authorChan, Casey-
dc.contributor.authorRaghunath, Michael-
dc.date.accessioned2018-10-26T14:33:08Z-
dc.date.available2018-10-26T14:33:08Z-
dc.date.issued2015-
dc.identifier.issn1043-1802de_CH
dc.identifier.issn1520-4812de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/12203-
dc.description.abstractBlend emulsion electrospinning is widely perceived to destroy the bioactivity of proteins, and a blend emulsion of water-soluble and nonsoluble molecules is believed to be thermodynamically unstable to electrospin smoothly. Here we demonstrate a method to retain the bioactivity of disparate fragile biomolecules when electrospun. Using bovine serum albumin as a carrier protein; water-soluble vitamin C, fat soluble vitamin D3, steroid hormone hydrocortisone, peptide hormone insulin, thyroid hormone triiodothyronine (T3), and peptide epidermal growth factor (EGF) were simultaneously blend-spun into PLGA-collagen nanofibers. Upon release, vitamin C maintained the ability to facilitate Type I collagen secretion by fibroblasts, EGF stimulated skin fibroblast proliferation, and insulin potentiated adipogenic differentiation. Transgenic cell reporter assays confirmed the bioactivity of vitamin D3, T3, and hydrocortisone. These factors concertedly increased keratinocyte and fibroblast proliferation while maintaining keratinocyte basal state. This method presents an elegant solution to simultaneously deliver disparate bioactive biomolecules for wound healing applications.de_CH
dc.language.isoende_CH
dc.publisherAmerican Chemical Societyde_CH
dc.relation.ispartofBioconjugate Chemistryde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject.ddc572: Biochemiede_CH
dc.subject.ddc617: Chirurgiede_CH
dc.titleSimultaneous delivery of highly diverse bioactive compounds from blend electrospun fibers for skin wound healingde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1021/acs.bioconjchem.5b00123de_CH
zhaw.funding.euNode_CH
zhaw.issue7de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.end1358de_CH
zhaw.pages.start1348de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume26de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedMetabolic Tissue Engineeringde_CH
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Peh, P., Lim, N. S. J., Blocki, A., Chee, S. M. L., Park, H. C., Liao, S., Chan, C., & Raghunath, M. (2015). Simultaneous delivery of highly diverse bioactive compounds from blend electrospun fibers for skin wound healing. Bioconjugate Chemistry, 26(7), 1348–1358. https://doi.org/10.1021/acs.bioconjchem.5b00123
Peh, P. et al. (2015) ‘Simultaneous delivery of highly diverse bioactive compounds from blend electrospun fibers for skin wound healing’, Bioconjugate Chemistry, 26(7), pp. 1348–1358. Available at: https://doi.org/10.1021/acs.bioconjchem.5b00123.
P. Peh et al., “Simultaneous delivery of highly diverse bioactive compounds from blend electrospun fibers for skin wound healing,” Bioconjugate Chemistry, vol. 26, no. 7, pp. 1348–1358, 2015, doi: 10.1021/acs.bioconjchem.5b00123.
PEH, Priscilla, Natalie Sheng Jie LIM, Anna BLOCKI, Stella Min Ling CHEE, Heyjin Chris PARK, Susan LIAO, Casey CHAN und Michael RAGHUNATH, 2015. Simultaneous delivery of highly diverse bioactive compounds from blend electrospun fibers for skin wound healing. Bioconjugate Chemistry. 2015. Bd. 26, Nr. 7, S. 1348–1358. DOI 10.1021/acs.bioconjchem.5b00123
Peh, Priscilla, Natalie Sheng Jie Lim, Anna Blocki, Stella Min Ling Chee, Heyjin Chris Park, Susan Liao, Casey Chan, and Michael Raghunath. 2015. “Simultaneous Delivery of Highly Diverse Bioactive Compounds from Blend Electrospun Fibers for Skin Wound Healing.” Bioconjugate Chemistry 26 (7): 1348–58. https://doi.org/10.1021/acs.bioconjchem.5b00123.
Peh, Priscilla, et al. “Simultaneous Delivery of Highly Diverse Bioactive Compounds from Blend Electrospun Fibers for Skin Wound Healing.” Bioconjugate Chemistry, vol. 26, no. 7, 2015, pp. 1348–58, https://doi.org/10.1021/acs.bioconjchem.5b00123.


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