Best practices in heterotrophic high-cell-density microalgal processes : achievements, potential and possible limitations

Bumbak, Fabian; Cook, Stella; Zachleder, Vilém; Hauser, Silas; Kovar, Karin

doi:10.21256/zhaw-4872

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-4872

Full metadata record

DC Field	Value	Language
dc.contributor.author	Bumbak, Fabian	-
dc.contributor.author	Cook, Stella	-
dc.contributor.author	Zachleder, Vilém	-
dc.contributor.author	Hauser, Silas	-
dc.contributor.author	Kovar, Karin	-
dc.date.accessioned	2018-11-16T10:10:16Z	-
dc.date.available	2018-11-16T10:10:16Z	-
dc.date.issued	2011	-
dc.identifier.issn	0175-7598	de_CH
dc.identifier.issn	1432-0614	de_CH
dc.identifier.uri	https://digitalcollection.zhaw.ch/handle/11475/12906	-
dc.description.abstract	Microalgae of numerous heterotrophic genera (obligate or facultative) exhibit considerable metabolic versatility and flexibility but are currently underexploited in the biotechnological manufacturing of known plant-derived compounds, novel high-value biomolecules or enriched biomass. Highly efficient production of microalgal biomass without the need for light is now feasible in inexpensive, well-defined mineral medium, typically supplemented with glucose. Cell densities of more than 100 g l(-1) cell dry weight have been achieved with Chlorella, Crypthecodinium and Galdieria species while controlling the addition of organic sources of carbon and energy in fedbatch mode. The ability of microalgae to adapt their metabolism to varying culture conditions provides opportunities to modify, control and thereby maximise the formation of targeted compounds with non-recombinant microalgae. This review outlines the critical aspects of cultivation technology and current best practices in the heterotrophic high-cell-density cultivation of microalgae. The primary topics include (1) the characteristics of microalgae that make them suitable for heterotrophic cultivation, (2) the appropriate chemical composition of mineral growth media, (3) the different strategies for fedbatch cultivations and (4) the principles behind the customisation of biomass composition. The review confirms that, although fundamental knowledge is now available, the development of efficient, economically feasible large-scale bioprocesses remains an obstacle to the commercialisation of this promising technology.	de_CH
dc.language.iso	en	de_CH
dc.publisher	Springer	de_CH
dc.relation.ispartof	Applied Microbiology and Biotechnology	de_CH
dc.rights	http://creativecommons.org/licenses/by-nc/4.0/	de_CH
dc.subject	Biomass	de_CH
dc.subject	Biotechnology	de_CH
dc.subject	Cell Culture Techniques	de_CH
dc.subject	Culture Media	de_CH
dc.subject	Microalgae	de_CH
dc.subject.ddc	570: Biologie	de_CH
dc.title	Best practices in heterotrophic high-cell-density microalgal processes : achievements, potential and possible limitations	de_CH
dc.type	Beitrag in wissenschaftlicher Zeitschrift	de_CH
dcterms.type	Text	de_CH
zhaw.departement	Life Sciences und Facility Management	de_CH
zhaw.organisationalunit	Institut für Lebensmittel- und Getränkeinnovation (ILGI)	de_CH
dc.identifier.doi	10.21256/zhaw-4872	-
dc.identifier.doi	10.1007/s00253-011-3311-6	de_CH
dc.identifier.pmid	21567179	de_CH
zhaw.funding.eu	No	de_CH
zhaw.issue	31	de_CH
zhaw.originated.zhaw	Yes	de_CH
zhaw.pages.end	46	de_CH
zhaw.pages.start	31	de_CH
zhaw.publication.status	publishedVersion	de_CH
zhaw.volume	91	de_CH
zhaw.publication.review	Peer review (Publikation)	de_CH
zhaw.webfeed	LM-Technologie	de_CH
Appears in collections:	Publikationen Life Sciences und Facility Management

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Bumbak, F., Cook, S., Zachleder, V., Hauser, S., & Kovar, K. (2011). Best practices in heterotrophic high-cell-density microalgal processes : achievements, potential and possible limitations. Applied Microbiology and Biotechnology, 91(31), 31–46. https://doi.org/10.21256/zhaw-4872

Bumbak, F. et al. (2011) ‘Best practices in heterotrophic high-cell-density microalgal processes : achievements, potential and possible limitations’, Applied Microbiology and Biotechnology, 91(31), pp. 31–46. Available at: https://doi.org/10.21256/zhaw-4872.

F. Bumbak, S. Cook, V. Zachleder, S. Hauser, and K. Kovar, “Best practices in heterotrophic high-cell-density microalgal processes : achievements, potential and possible limitations,” Applied Microbiology and Biotechnology, vol. 91, no. 31, pp. 31–46, 2011, doi: 10.21256/zhaw-4872.

BUMBAK, Fabian, Stella COOK, Vilém ZACHLEDER, Silas HAUSER und Karin KOVAR, 2011. Best practices in heterotrophic high-cell-density microalgal processes : achievements, potential and possible limitations. Applied Microbiology and Biotechnology. 2011. Bd. 91, Nr. 31, S. 31–46. DOI 10.21256/zhaw-4872

Bumbak, Fabian, Stella Cook, Vilém Zachleder, Silas Hauser, and Karin Kovar. 2011. “Best Practices in Heterotrophic High-Cell-Density Microalgal Processes : Achievements, Potential and Possible Limitations.” Applied Microbiology and Biotechnology 91 (31): 31–46. https://doi.org/10.21256/zhaw-4872.

Bumbak, Fabian, et al. “Best Practices in Heterotrophic High-Cell-Density Microalgal Processes : Achievements, Potential and Possible Limitations.” Applied Microbiology and Biotechnology, vol. 91, no. 31, 2011, pp. 31–46, https://doi.org/10.21256/zhaw-4872.