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dc.contributor.authorBijlenga, Philippe-
dc.contributor.authorGondar, Renato-
dc.contributor.authorSchilling, Sabine-
dc.contributor.authorMorel, Sandrine-
dc.contributor.authorHirsch, Sven-
dc.contributor.authorCuony, Johanna-
dc.contributor.authorCorniola, Marco-Vincenzo-
dc.contributor.authorPerren, Fabienne-
dc.contributor.authorRüfenacht, Daniel-
dc.contributor.authorSchaller, Karl-
dc.date.accessioned2018-12-06T13:07:04Z-
dc.date.available2018-12-06T13:07:04Z-
dc.date.issued2017-
dc.identifier.issn0039-2499de_CH
dc.identifier.issn1524-4628de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/13615-
dc.description.abstractBackground and Purpose: The aim of this study is to assess whether the PHASES score allows to (1) match decisions taken by multidisciplinary team whether to observe or intervene, (2) classify patients being diagnosed with a ruptured versus unruptured intracranial aneurysm (UIA), and (3) discriminate patients at low risk of rupture from the population of patients diagnosed with intracranial aneurysm. Methods: Population-based prospective and consecutive data were collected between 2006 and 2014. Patients (n=841) were stratified into 4 groups: stable UIA; growing observed UIA; immediately treated UIA; and aneurysmal subarachnoid hemorrhage (aSAH). All patients initially observed were pooled in a follow-up UIA group; patients from growing observed UIA, immediately treated UIA, and aSAH were pooled in a high risk of rupture group. Results are expressed as median [quartile 1, quartile 3]. Results: PHASES scores of immediately treated UIA patients were significantly higher than follow-up UIA group (5 [3, 7] versus 2 [1, 4]). Patients diagnosed with UIA and PHASES score of >3 were more likely to be treated, and the score ≤3 was predictive for observation (areas under these curves=0.74). Odds of being diagnosed with an aSAH were associated with PHASES score of >3 (UIA, 4 [2, 6]; aSAH, 5 [4, 8]; areas under these curves=0.66). Scores of stable UIA patients were significantly lower than high risk of rupture group (2 [1, 4] versus 5 [4, 7]; stable UIA outcome prediction by PHASES score of ≤3: areas under these curves=0.76). Conclusions: There is a progression of PHASES score between stable UIA, growing observed UIA, immediately treated UIA, and aSAH groups. PHASES score of ≤3 is associated with a low but not negligible likelihood of aneurysm rupture, and specificity of the classifier is low.de_CH
dc.language.isoende_CH
dc.publisherLippincott Williams & Wilkinsde_CH
dc.relation.ispartofStroke: A Journal of Cerebral Circulationde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectHypertensionde_CH
dc.subjectIntracranial aneurysmde_CH
dc.subjectProbabilityde_CH
dc.subjectRiskde_CH
dc.subjectSubarachnoid hemorrhagede_CH
dc.subject.ddc616.8: Neurologie und Krankheiten des Nervensystemsde_CH
dc.titlePHASES score for the management of intracranial aneurysmde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Computational Life Sciences (ICLS)de_CH
dc.identifier.doi10.1161/STROKEAHA.117.017391de_CH
dc.identifier.pmid28667020de_CH
zhaw.funding.euNode_CH
zhaw.issue8de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end2112de_CH
zhaw.pages.start2105de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume48de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedBiomedical Simulationde_CH
zhaw.funding.zhawAneuXde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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