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dc.contributor.authorHirsch, Sven-
dc.contributor.authorEgger, Julian-
dc.contributor.authorWanke, Isabel-
dc.contributor.authorKulcsar, Zsolt-
dc.contributor.authorRüfenacht, Daniel-
dc.date.accessioned2018-12-14T15:43:26Z-
dc.date.available2018-12-14T15:43:26Z-
dc.date.issued2013-
dc.identifier.isbn978-0-9562914-2-4de_CH
dc.identifier.issn2227-3085de_CH
dc.identifier.issn2227-9385de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/13871-
dc.description.abstractWe present a clinical perspective, supported by biological findings, reflecting the potential of computational tools to understand and treat intracranial aneurysms. Thrombus formation and chronic inflammation are integral to disease progression, driven by blood flow energy. The interplay between flow energy, blood clotting and remodeling of the tissue is key to an enhanced disease understanding, to improve patient counseling and ultimately endovascular treatment planning. Current concepts suggest that blood governs wall remodeling by multiple biological steps. The process starts with flow induced thrombus adhesion (atherothrombosis) to the wall that secondarily leads to the release of biological mediators of inflammation entertaining destructive remodeling. Destructive wall remodeling jeopardizes the mechanical wall integrity with ensuing circumscribed softening and expansion of the aneurysm shape. The shape of an aneurysm is the visible result of these complex pathological processes and characterizes its disease status. Wall adherent thrombus formation, inflammatory reactions and the driving force of blood flow cause lumen shape changes. Here, shape irregularity is a distinctive sign of focal wall weakening. The integration of shape-analysis,vascular biology and phenotypical information will allow for personalized characterization of aneurysmal vascular disease and help to identify and establish shape as an image-based biomarker. Future translational efforts should aim at providing adequate IT tools and contributing to validation and disease understanding. Ensuing results will have a high likelihood to impact significantly on current clinical disease management.de_CH
dc.language.isoende_CH
dc.publisherCity University of Hong Kongde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectBiomedical simulationde_CH
dc.subjectIntracranial aneurysmsde_CH
dc.subjectBlood flowde_CH
dc.subjectThrombusde_CH
dc.subjectRemodelingde_CH
dc.subjectEndovascular treatmentde_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleClinical relevance of mechano-biological transduction in intracranial aneurysms : the mediating role of thrombus formation and inflammatory response expressing as aneurysm shapede_CH
dc.typeKonferenz: Paperde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Computational Life Sciences (ICLS)de_CH
zhaw.publisher.placeHong Kongde_CH
zhaw.conference.detailsCMBE 2013, Hong Kong, , 16-18 December 2013de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end110de_CH
zhaw.pages.start107de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.title.proceedingsCMBE13 : 3rd International Conference on Computational & Mathematical Biomedical Engineeringde_CH
zhaw.funding.snfCR32I3 127008de_CH
zhaw.webfeedBiomedical Simulationde_CH
zhaw.funding.zhawAneuXde_CH
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Hirsch, S., Egger, J., Wanke, I., Kulcsar, Z., & Rüfenacht, D. (2013). Clinical relevance of mechano-biological transduction in intracranial aneurysms : the mediating role of thrombus formation and inflammatory response expressing as aneurysm shape [Conference paper]. CMBE13 : 3rd International Conference on Computational & Mathematical Biomedical Engineering, 107–110.
Hirsch, S. et al. (2013) ‘Clinical relevance of mechano-biological transduction in intracranial aneurysms : the mediating role of thrombus formation and inflammatory response expressing as aneurysm shape’, in CMBE13 : 3rd International Conference on Computational & Mathematical Biomedical Engineering. Hong Kong: City University of Hong Kong, pp. 107–110.
S. Hirsch, J. Egger, I. Wanke, Z. Kulcsar, and D. Rüfenacht, “Clinical relevance of mechano-biological transduction in intracranial aneurysms : the mediating role of thrombus formation and inflammatory response expressing as aneurysm shape,” in CMBE13 : 3rd International Conference on Computational & Mathematical Biomedical Engineering, 2013, pp. 107–110.
HIRSCH, Sven, Julian EGGER, Isabel WANKE, Zsolt KULCSAR und Daniel RÜFENACHT, 2013. Clinical relevance of mechano-biological transduction in intracranial aneurysms : the mediating role of thrombus formation and inflammatory response expressing as aneurysm shape. In: CMBE13 : 3rd International Conference on Computational & Mathematical Biomedical Engineering. Conference paper. Hong Kong: City University of Hong Kong. 2013. S. 107–110. ISBN 978-0-9562914-2-4
Hirsch, Sven, Julian Egger, Isabel Wanke, Zsolt Kulcsar, and Daniel Rüfenacht. 2013. “Clinical Relevance of Mechano-Biological Transduction in Intracranial Aneurysms : The Mediating Role of Thrombus Formation and Inflammatory Response Expressing as Aneurysm Shape.” Conference paper. In CMBE13 : 3rd International Conference on Computational & Mathematical Biomedical Engineering, 107–10. Hong Kong: City University of Hong Kong.
Hirsch, Sven, et al. “Clinical Relevance of Mechano-Biological Transduction in Intracranial Aneurysms : The Mediating Role of Thrombus Formation and Inflammatory Response Expressing as Aneurysm Shape.” CMBE13 : 3rd International Conference on Computational & Mathematical Biomedical Engineering, City University of Hong Kong, 2013, pp. 107–10.


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