Sub-clinical psychosis symptoms in young adults are risk factors for subsequent common mental disorders

Rössler, Wulf; Hengartner, Michael Pascal; Ajdacic-Gross, Vladeta; Haker, Helene; Gamma, Alex; Angst, Jules

doi:10.1016/j.schres.2011.06.019

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Sub-clinical psychosis symptoms in young adults are risk factors for subsequent common mental disorders
Authors:	Rössler, Wulf Hengartner, Michael Pascal Ajdacic-Gross, Vladeta Haker, Helene Gamma, Alex Angst, Jules
DOI:	10.1016/j.schres.2011.06.019
Published in:	Schizophrenia Research
Volume(Issue):	131
Issue:	1-3
Page(s):	18
Pages to:	23
Issue Date:	2011
Publisher / Ed. Institution:	Elsevier
ISSN:	0920-9964 1573-2509
Language:	English
Subjects:	Adult; Area Under Curve; Bipolar Disorder; Cohort Studies; Female; Humans; Logistic Models; Male; Mental Disorders; Middle Aged; Obsessive-Compulsive Disorder; Phobic Disorders; Psychiatric Status Rating Scales; Psychotic Disorders; Retrospective Studies; Risk Factors; Young Adult
Subject (DDC):	616.89: Mental disorders, clinical psychology and psychiatry
Abstract:	Background: Not all persons identified in the early stages to be at risk for psychosis eventually cross the threshold for a psychotic illness. However, sub-clinical symptoms may not only indicate a specific risk but also suggest a more general, underlying psychopathology that predisposes one to various common mental disorders. Methods: Analyzing data from the prospective Zurich Cohort Study, we used two psychosis subscales – “schizotypal signs” and “schizophrenia nuclear symptoms” – derived from the SCL-90-R checklist that measured sub-clinical psychosis symptoms in 1979. We also assessed 10 different diagnoses of common mental disorders through seven interview waves between 1979 and 2008. This 30-year span, covering participant ages of 19/20 to 49/50, encompasses the period of highest risk for the occurrence of such disorders. Results: Both psychosis scales from 1979, but especially “schizotypal signs”, were significantly correlated with most mental disorders over the subsequent test period. Higher values on both subscales were associated with an increasing number of co-occurring disorders. Conclusions: Our data demonstrate that sub-clinical psychosis generally represents a risk factor for the development of common mental disorders and a liability for co-occurring disorders. This refers in particular to dysthymia, bipolar disorder, social phobia, and obsessive–compulsive disorder. Proneness to psychosis could signal a fundamental tendency toward common mental disorders.
URI:	https://digitalcollection.zhaw.ch/handle/11475/15117
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Applied Psychology
Organisational Unit:	Psychological Institute (PI)
Appears in collections:	Publikationen Angewandte Psychologie

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Rössler, W., Hengartner, M. P., Ajdacic-Gross, V., Haker, H., Gamma, A., & Angst, J. (2011). Sub-clinical psychosis symptoms in young adults are risk factors for subsequent common mental disorders. Schizophrenia Research, 131(1-3), 18–23. https://doi.org/10.1016/j.schres.2011.06.019

Rössler, W. et al. (2011) ‘Sub-clinical psychosis symptoms in young adults are risk factors for subsequent common mental disorders’, Schizophrenia Research, 131(1-3), pp. 18–23. Available at: https://doi.org/10.1016/j.schres.2011.06.019.

W. Rössler, M. P. Hengartner, V. Ajdacic-Gross, H. Haker, A. Gamma, and J. Angst, “Sub-clinical psychosis symptoms in young adults are risk factors for subsequent common mental disorders,” Schizophrenia Research, vol. 131, no. 1-3, pp. 18–23, 2011, doi: 10.1016/j.schres.2011.06.019.

RÖSSLER, Wulf, Michael Pascal HENGARTNER, Vladeta AJDACIC-GROSS, Helene HAKER, Alex GAMMA und Jules ANGST, 2011. Sub-clinical psychosis symptoms in young adults are risk factors for subsequent common mental disorders. Schizophrenia Research. 2011. Bd. 131, Nr. 1-3, S. 18–23. DOI 10.1016/j.schres.2011.06.019

Rössler, Wulf, Michael Pascal Hengartner, Vladeta Ajdacic-Gross, Helene Haker, Alex Gamma, and Jules Angst. 2011. “Sub-Clinical Psychosis Symptoms in Young Adults Are Risk Factors for Subsequent Common Mental Disorders.” Schizophrenia Research 131 (1-3): 18–23. https://doi.org/10.1016/j.schres.2011.06.019.

Rössler, Wulf, et al. “Sub-Clinical Psychosis Symptoms in Young Adults Are Risk Factors for Subsequent Common Mental Disorders.” Schizophrenia Research, vol. 131, no. 1-3, 2011, pp. 18–23, https://doi.org/10.1016/j.schres.2011.06.019.