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dc.contributor.authorWeidenbacher, Lukas-
dc.contributor.authorMüller, Eike-
dc.contributor.authorGuex, Anne Géraldine-
dc.contributor.authorZündel, Manuel-
dc.contributor.authorSchweizer, Peter-
dc.contributor.authorMarina, Vita-
dc.contributor.authorAdlhart, Christian-
dc.contributor.authorVejsadová, Lucie-
dc.contributor.authorPauer, Robin-
dc.contributor.authorSpiecker, Erdmann-
dc.contributor.authorManiura-Weber, Katharina-
dc.contributor.authorFerguson, Stephen J.-
dc.contributor.authorRossi, René M.-
dc.contributor.authorRottmar, Markus-
dc.contributor.authorFortunato, Giuseppino-
dc.date.accessioned2019-02-07T16:07:15Z-
dc.date.available2019-02-07T16:07:15Z-
dc.date.issued2019-
dc.identifier.issn1944-8244de_CH
dc.identifier.issn1944-8252de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/15177-
dc.description.abstractDespite major technological advances within the field of cardiovascular engineering, the risk of thromboembolic events on artificial surfaces in contact with blood remains a major challenge and limits the functionality of ventricular assist devices (VADs) during mid- or long-term therapy. Here, a biomimetic blood–material interface is created via a nanofiber-based approach that promotes the endothelialization capability of elastic silicone surfaces for next-generation VADs under elevated hemodynamic loads. A blend fiber membrane made of elastic polyurethane and low-thrombogenic poly(vinylidene fluoride-co-hexafluoropropylene) was partially embedded into the surface of silicone films. These blend membranes resist fundamental irreversible deformation of the internal structure and are stably attached to the surface, while also exhibiting enhanced antithrombotic properties when compared to bare silicone. The composite material supports the formation of a stable monolayer of endothelial cells within a pulsatile flow bioreactor, resembling the physiological in vivo situation in a VAD. The nanofiber surface modification concept thus presents a promising approach for the future design of advanced elastic composite materials that are particularly interesting for applications in contact with blood.de_CH
dc.language.isoende_CH
dc.publisherAmerican Chemical Societyde_CH
dc.relation.ispartofACS Applied Materials & Interfacesde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectElectrospun composite materialsde_CH
dc.subjectEndothelializationde_CH
dc.subjectFluorinated surface functionalizationde_CH
dc.subjectPulsatile flow bioreactorde_CH
dc.subjectThrombogenicityde_CH
dc.subject.ddc660: Technische Chemiede_CH
dc.titleIn vitro endothelialization of surface-integrated nanofiber networks for stretchable blood interfacesde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1021/acsami.8b18121de_CH
dc.identifier.pmid30668107de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedFunktionsmaterialien und Nanotechnologiede_CH
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Weidenbacher, L., Müller, E., Guex, A. G., Zündel, M., Schweizer, P., Marina, V., Adlhart, C., Vejsadová, L., Pauer, R., Spiecker, E., Maniura-Weber, K., Ferguson, S. J., Rossi, R. M., Rottmar, M., & Fortunato, G. (2019). In vitro endothelialization of surface-integrated nanofiber networks for stretchable blood interfaces. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.8b18121
Weidenbacher, L. et al. (2019) ‘In vitro endothelialization of surface-integrated nanofiber networks for stretchable blood interfaces’, ACS Applied Materials & Interfaces [Preprint]. Available at: https://doi.org/10.1021/acsami.8b18121.
L. Weidenbacher et al., “In vitro endothelialization of surface-integrated nanofiber networks for stretchable blood interfaces,” ACS Applied Materials & Interfaces, 2019, doi: 10.1021/acsami.8b18121.
WEIDENBACHER, Lukas, Eike MÜLLER, Anne Géraldine GUEX, Manuel ZÜNDEL, Peter SCHWEIZER, Vita MARINA, Christian ADLHART, Lucie VEJSADOVÁ, Robin PAUER, Erdmann SPIECKER, Katharina MANIURA-WEBER, Stephen J. FERGUSON, René M. ROSSI, Markus ROTTMAR und Giuseppino FORTUNATO, 2019. In vitro endothelialization of surface-integrated nanofiber networks for stretchable blood interfaces. ACS Applied Materials & Interfaces. 2019. DOI 10.1021/acsami.8b18121
Weidenbacher, Lukas, Eike Müller, Anne Géraldine Guex, Manuel Zündel, Peter Schweizer, Vita Marina, Christian Adlhart, et al. 2019. “In Vitro Endothelialization of Surface-Integrated Nanofiber Networks for Stretchable Blood Interfaces.” ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.8b18121.
Weidenbacher, Lukas, et al. “In Vitro Endothelialization of Surface-Integrated Nanofiber Networks for Stretchable Blood Interfaces.” ACS Applied Materials & Interfaces, 2019, https://doi.org/10.1021/acsami.8b18121.


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