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dc.contributor.authorZuzak, T.-
dc.contributor.authorRist, L.-
dc.contributor.authorEggenschwiler, J.-
dc.contributor.authorGrotzer, M. A.-
dc.contributor.authorViviani, A.-
dc.date.accessioned2019-02-13T14:41:48Z-
dc.date.available2019-02-13T14:41:48Z-
dc.date.issued2006-
dc.identifier.issn0250-7005de_CH
dc.identifier.issn1791-7530de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/15305-
dc.description.abstractBackground: Medulloblastoma constitute more than 20% of all paediatric brain tumours and are the most common malignant brain tumours in children. Adjuvant chemotherapy has seen a strong increase in the use of complementary medicine for cancer treatment. Evidence for cytotoxic and apoptotic effects of Viscum album (Mistletoe) in vitro is available, however, no data concerning paediatric tumours, especially paediatric brain tumours, has been provided so far. Materials and methods: In order to compare the receptiveness of medulloblastoma cells to different Viscum album preparations, in vitro cytotoxic effects of eight Viscum album extracts on four different paediatric medulloblastoma cell lines were analysed by MTT-Tests. Lectin contents of the extracts were determined to correlate them with the mitochondrial activity of mistletoe-treated cells. Flowcytometric analyses with Annexin V-FITC staining were carried out to quantify the amount of apoptotic cells compared to necrotic and viable cells. Results: Data obtained with the medulloblastoma cell lines, Daoy, D342, D425 and UW-288-2, treated with Viscum album preparations from eight dissimilar host trees (Iscucin Abietis, Pini, Populi, Mali, Salicis, Crataegi, Quercus and Tiliae), indicated a significant growth-inhibition of all cell lines, yet the cell susceptibility was dissimilar against the different extracts. The decrease in mitochondrial activity and increase in apoptosis correlated with the lectin content of the used preparation in a dose-dependent manner. Conclusion: These in vitro results show that paediatric medulloblastoma cells respond to Viscum album preparations, by undergoing cell death through apoptosis and that this growth-inhibition correlates with the lectin content of the used preparation.de_CH
dc.language.isoende_CH
dc.publisherInternational Institute of Anticancer Researchde_CH
dc.relation.ispartofAnticancer Researchde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectViscumde_CH
dc.subjectTumourde_CH
dc.subjectMedulloblastomade_CH
dc.subjectBrainde_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titlePaediatic medulloblastoma cells are susceptible to Viscum album L. (mistletoe) preparationsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.funding.euNode_CH
zhaw.issue5Ade_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end3492de_CH
zhaw.pages.start3485de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume26de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedZellphysiologiede_CH
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Zuzak, T., Rist, L., Eggenschwiler, J., Grotzer, M. A., & Viviani, A. (2006). Paediatic medulloblastoma cells are susceptible to Viscum album L. (mistletoe) preparations. Anticancer Research, 26(5A), 3485–3492.
Zuzak, T. et al. (2006) ‘Paediatic medulloblastoma cells are susceptible to Viscum album L. (mistletoe) preparations’, Anticancer Research, 26(5A), pp. 3485–3492.
T. Zuzak, L. Rist, J. Eggenschwiler, M. A. Grotzer, and A. Viviani, “Paediatic medulloblastoma cells are susceptible to Viscum album L. (mistletoe) preparations,” Anticancer Research, vol. 26, no. 5A, pp. 3485–3492, 2006.
ZUZAK, T., L. RIST, J. EGGENSCHWILER, M. A. GROTZER und A. VIVIANI, 2006. Paediatic medulloblastoma cells are susceptible to Viscum album L. (mistletoe) preparations. Anticancer Research. 2006. Bd. 26, Nr. 5A, S. 3485–3492
Zuzak, T., L. Rist, J. Eggenschwiler, M. A. Grotzer, and A. Viviani. 2006. “Paediatic Medulloblastoma Cells Are Susceptible to Viscum Album L. (Mistletoe) Preparations.” Anticancer Research 26 (5A): 3485–92.
Zuzak, T., et al. “Paediatic Medulloblastoma Cells Are Susceptible to Viscum Album L. (Mistletoe) Preparations.” Anticancer Research, vol. 26, no. 5A, 2006, pp. 3485–92.


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