| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Synthetic 3D multicellular systems for drug development |
| Authors: | Rimann, Markus Graf-Hausner, Ursula |
| DOI: | 10.1016/j.copbio.2012.01.011 |
| Published in: | Current Opinion in Biotechnology |
| Volume(Issue): | 23 |
| Issue: | 5 |
| Page(s): | 803 |
| Pages to: | 809 |
| Issue Date: | 2012 |
| Publisher / Ed. Institution: | Elsevier |
| ISSN: | 0958-1669 1879-0429 |
| Language: | English |
| Subject (DDC): | 615: Pharmacology and therapeutics 660.6: Biotechnology |
| Abstract: | Since the 1970s, the limitations of two dimensional (2D) cell culture and the relevance of appropriate three dimensional (3D) cell systems have become increasingly evident. Extensive effort has thus been made to move cells from a flat world to a 3D environment. While 3D cell culture technologies are meanwhile widely used in academia, 2D culture technologies are still entrenched in the (pharmaceutical) industry for most kind of cell-based efficacy and toxicology tests. However, 3D cell culture technologies will certainly become more applicable if biological relevance, reproducibility and high throughput can be assured at acceptable costs. Most recent innovations and developments clearly indicate that the transition from 2D to 3D cell culture for industrial purposes, for example, drug development is simply a question of time. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/1604 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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Rimann, M., & Graf-Hausner, U. (2012). Synthetic 3D multicellular systems for drug development. Current Opinion in Biotechnology, 23(5), 803–809. https://doi.org/10.1016/j.copbio.2012.01.011
Rimann, M. and Graf-Hausner, U. (2012) ‘Synthetic 3D multicellular systems for drug development’, Current Opinion in Biotechnology, 23(5), pp. 803–809. Available at: https://doi.org/10.1016/j.copbio.2012.01.011.
M. Rimann and U. Graf-Hausner, “Synthetic 3D multicellular systems for drug development,” Current Opinion in Biotechnology, vol. 23, no. 5, pp. 803–809, 2012, doi: 10.1016/j.copbio.2012.01.011.
RIMANN, Markus und Ursula GRAF-HAUSNER, 2012. Synthetic 3D multicellular systems for drug development. Current Opinion in Biotechnology. 2012. Bd. 23, Nr. 5, S. 803–809. DOI 10.1016/j.copbio.2012.01.011
Rimann, Markus, and Ursula Graf-Hausner. 2012. “Synthetic 3D Multicellular Systems for Drug Development.” Current Opinion in Biotechnology 23 (5): 803–9. https://doi.org/10.1016/j.copbio.2012.01.011.
Rimann, Markus, and Ursula Graf-Hausner. “Synthetic 3D Multicellular Systems for Drug Development.” Current Opinion in Biotechnology, vol. 23, no. 5, 2012, pp. 803–9, https://doi.org/10.1016/j.copbio.2012.01.011.
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