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dc.contributor.authorRoth-Konforti, Michal-
dc.contributor.authorGreen, Ori-
dc.contributor.authorHupfeld, Mario-
dc.contributor.authorFieseler, Lars-
dc.contributor.authorHeinrich, Nadine-
dc.contributor.authorIhssen, Julian-
dc.contributor.authorVorberg, Raffael-
dc.contributor.authorWick, Lukas-
dc.contributor.authorSpitz, Urs-
dc.contributor.authorShabat, Doron-
dc.date.accessioned2019-10-16T13:52:56Z-
dc.date.available2019-10-16T13:52:56Z-
dc.date.issued2019-
dc.identifier.issn1433-7851de_CH
dc.identifier.issn1521-3773de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/18412-
dc.description.abstractDetection of Salmonella and L. monocytogenes in food samples by current diagnostic methods requires relatively long time to results (2-6 days). Furthermore, the ability to perform environmental monitoring at the factory site for these pathogens is limited due to the need for laboratory facilities. Herein, we report new chemiluminescence probes for the ultrasensitive direct detection of viable pathogenic bacteria. The probes are composed of a bright phenoxy-dioxetane luminophore masked by triggering group, which is activated by a specific bacterial enzyme, and could detect their corresponding bacteria with an LOD value of about 600-fold lower than that of fluorescent probes. Moreover, we were able to detect a minimum of 10 Salmonella cells within 6 h incubation. The assay allows for bacterial enrichment and detection in one test tube without further sample preparation. We anticipate that this design strategy will be used to prepare analogous chemiluminescence probes for other enzymes relevant to specific bacteria detection and point-of-care diagnostics.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofAngewandte Chemie: International Editionde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectListeriade_CH
dc.subjectSalmonellade_CH
dc.subjectBacterial probede_CH
dc.subjectChemiluminescencede_CH
dc.subjectDioxetanesde_CH
dc.subject.ddc660: Technische Chemiede_CH
dc.titleUltrasensitive detection of salmonella and listeria monocytogenes by small-molecule chemiluminescence probesde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Lebensmittel- und Getränkeinnovation (ILGI)de_CH
dc.identifier.doi10.1002/anie.201904719de_CH
dc.identifier.pmid31233265de_CH
zhaw.funding.euNode_CH
zhaw.issue30de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end10367de_CH
zhaw.pages.start10361de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume58de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedMikrobiologiede_CH
zhaw.funding.zhawNachweis von L. monocytogenes und Salmonella in Lebensmitteln und von Oberflächenabstrichen mittels AquaSparkTM Technologiede_CH
zhaw.author.additionalNode_CH
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Roth-Konforti, M., Green, O., Hupfeld, M., Fieseler, L., Heinrich, N., Ihssen, J., Vorberg, R., Wick, L., Spitz, U., & Shabat, D. (2019). Ultrasensitive detection of salmonella and listeria monocytogenes by small-molecule chemiluminescence probes. Angewandte Chemie: International Edition, 58(30), 10361–10367. https://doi.org/10.1002/anie.201904719
Roth-Konforti, M. et al. (2019) ‘Ultrasensitive detection of salmonella and listeria monocytogenes by small-molecule chemiluminescence probes’, Angewandte Chemie: International Edition, 58(30), pp. 10361–10367. Available at: https://doi.org/10.1002/anie.201904719.
M. Roth-Konforti et al., “Ultrasensitive detection of salmonella and listeria monocytogenes by small-molecule chemiluminescence probes,” Angewandte Chemie: International Edition, vol. 58, no. 30, pp. 10361–10367, 2019, doi: 10.1002/anie.201904719.
ROTH-KONFORTI, Michal, Ori GREEN, Mario HUPFELD, Lars FIESELER, Nadine HEINRICH, Julian IHSSEN, Raffael VORBERG, Lukas WICK, Urs SPITZ und Doron SHABAT, 2019. Ultrasensitive detection of salmonella and listeria monocytogenes by small-molecule chemiluminescence probes. Angewandte Chemie: International Edition. 2019. Bd. 58, Nr. 30, S. 10361–10367. DOI 10.1002/anie.201904719
Roth-Konforti, Michal, Ori Green, Mario Hupfeld, Lars Fieseler, Nadine Heinrich, Julian Ihssen, Raffael Vorberg, Lukas Wick, Urs Spitz, and Doron Shabat. 2019. “Ultrasensitive Detection of Salmonella and Listeria Monocytogenes by Small-Molecule Chemiluminescence Probes.” Angewandte Chemie: International Edition 58 (30): 10361–67. https://doi.org/10.1002/anie.201904719.
Roth-Konforti, Michal, et al. “Ultrasensitive Detection of Salmonella and Listeria Monocytogenes by Small-Molecule Chemiluminescence Probes.” Angewandte Chemie: International Edition, vol. 58, no. 30, 2019, pp. 10361–67, https://doi.org/10.1002/anie.201904719.


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