Photostability of sennosides in solution and their degradation products 1

Meier, Nadja; Meier, Beat; Peter, Samuel; Josic, Goijko; Wolfram, Evelyn

doi:10.1055/s-0037-1608273

Publication type:	Conference poster
Type of review:	Peer review (abstract)
Title:	Photostability of sennosides in solution and their degradation products 1
Authors:	Meier, Nadja Meier, Beat Peter, Samuel Josic, Goijko Wolfram, Evelyn
DOI:	10.1055/s-0037-1608273
Published in:	Planta Medica International Open
Volume(Issue):	4
Conference details:	65th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA 2017), Basel, 3-6 September 2017
Issue Date:	24-Oct-2017
Publisher / Ed. Institution:	Thieme
ISSN:	2509-6656 2509-9264
Language:	English
Subject (DDC):	615: Pharmacology and therapeutics 660.6: Biotechnology
Abstract:	The leaves and pods of Alexandrian and Tinnevelly senna were used for centuries as laxatives. Their main active constituents are the dianthron glucosides (sennoside A – D and A1) and anthraquinone glucosides [1]. The photochemical instability of sennoside A was published in 1980 [2]. The authors postulated a degradation to rhein. However, the degradation products were not well examined and only one solvent was used in the study. The aim was to test the photostability of sennosides A, B and C in different solvents, to detect the degradation products as well as to examine if and when the aglycones aloe-emodin and rhein are formed. Sennosides were dissolved in different solvents and exposed to light (Fluora® growth lamps), samples were taken over a period of 14 days to 1 month and analysed by UHPLC-PDA/QDa. After 18h of light exposure 50 – 60% of the sennosides degraded in a solution with methanol/0.1% sodium bicarbonate (70:30 v/v) into other sennosides and rhein-8-glucoside. The effect is less distinct in solution of 0.1%sodium bicarbonatewith a degradation of ˜10% and did not occur with storage at room temperature and 4 °C while protected from light. Also, further degradation was stopped without light exposure. A formation of the aglycones aloe-emodin or rhein was not measured at any time, in contrary, in a senna extract exposed to light rhein degraded as well. [1] Hänsel, R. & Sticher, O. Pharmakognosie – Phytopharmazie 9th edition. Springer Medizin Verlag Heidelberg; 2010 [2] Nabil Aboul-Enein M, Wasser G.M, El-Difrawy S.M. Fitoterapia 1980; 51: 157 – 159.
URI:	https://digitalcollection.zhaw.ch/handle/11475/1962
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

Files in This Item:

There are no files associated with this item.

Show full item record

Meier, N., Meier, B., Peter, S., Josic, G., & Wolfram, E. (2017). Photostability of sennosides in solution and their degradation products 1 [Conference poster]. Planta Medica International Open, 4. https://doi.org/10.1055/s-0037-1608273

Meier, N. et al. (2017) ‘Photostability of sennosides in solution and their degradation products 1’, in Planta Medica International Open. Thieme. Available at: https://doi.org/10.1055/s-0037-1608273.

N. Meier, B. Meier, S. Peter, G. Josic, and E. Wolfram, “Photostability of sennosides in solution and their degradation products 1,” in Planta Medica International Open, Oct. 2017, vol. 4. doi: 10.1055/s-0037-1608273.

MEIER, Nadja, Beat MEIER, Samuel PETER, Goijko JOSIC und Evelyn WOLFRAM, 2017. Photostability of sennosides in solution and their degradation products 1. In: Planta Medica International Open. Conference poster. Thieme. 24 Oktober 2017

Meier, Nadja, Beat Meier, Samuel Peter, Goijko Josic, and Evelyn Wolfram. 2017. “Photostability of Sennosides in Solution and Their Degradation Products 1.” Conference poster. In Planta Medica International Open. Vol. 4. Thieme. https://doi.org/10.1055/s-0037-1608273.

Meier, Nadja, et al. “Photostability of Sennosides in Solution and Their Degradation Products 1.” Planta Medica International Open, vol. 4, Thieme, 2017, https://doi.org/10.1055/s-0037-1608273.