Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes

Jossen, Valentin; Eibl-Schindler, Regine; Pörtner, Ralf; Kraume, Matthias; Eibl, Dieter

doi:10.1016/B978-0-444-63663-8.00007-0

Publication type:	Book part
Type of review:	Editorial review
Title:	Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes
Authors:	Jossen, Valentin Eibl-Schindler, Regine Pörtner, Ralf Kraume, Matthias Eibl, Dieter
et. al:	No
DOI:	10.1016/B978-0-444-63663-8.00007-0
Published in:	Current Developments in Biotechnology and Bioengineering
Page(s):	179
Pages to:	215
Issue Date:	2017
Publisher / Ed. Institution:	Elsevier
ISBN:	9780444636638
Language:	English
Subjects:	Bioreactor mode; Key engineering issue; Mammalian cell; Microorganism; Reusable; Single use; Transport phenomenom
Subject (DDC):	660: Chemical engineering
Abstract:	It is undisputed that stirred bioreactors are the most common type of bioreactors for submerged bioprocesses. Stirred bioreactors for biopharmaceuticals, which represent the strongest-growing branch of modern biotechnological products, are the focus of our chapter. They are available in working volumes from milliliters up to 70 m3 and are used for a wide range of expression systems that require aseptic conditions. Based on a brief summary of some basic rules for the construction and operation of stirred bioreactors, this chapter will review key engineering issues that affect the design of aseptic stirred bioreactors. We will also provide readers with some general information on transport phenomena in stirred bioreactors before discussing special design aspects and performance parameters for expression systems (mammalian and microbial cells) that prevail in commercial biopharmaceutical production processes. Special attention will be paid to single-use stirred bioreactors, which may have advantages over their reusable counterparts and have become widely accepted over the past years.
URI:	https://digitalcollection.zhaw.ch/handle/11475/19652
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Jossen, V., Eibl-Schindler, R., Pörtner, R., Kraume, M., & Eibl, D. (2017). Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes. In Current Developments in Biotechnology and Bioengineering (pp. 179–215). Elsevier. https://doi.org/10.1016/B978-0-444-63663-8.00007-0

Jossen, V. et al. (2017) ‘Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes’, in Current Developments in Biotechnology and Bioengineering. Elsevier, pp. 179–215. Available at: https://doi.org/10.1016/B978-0-444-63663-8.00007-0.

V. Jossen, R. Eibl-Schindler, R. Pörtner, M. Kraume, and D. Eibl, “Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes,” in Current Developments in Biotechnology and Bioengineering, Elsevier, 2017, pp. 179–215. doi: 10.1016/B978-0-444-63663-8.00007-0.

JOSSEN, Valentin, Regine EIBL-SCHINDLER, Ralf PÖRTNER, Matthias KRAUME und Dieter EIBL, 2017. Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes. In: Current Developments in Biotechnology and Bioengineering. Elsevier. S. 179–215. ISBN 9780444636638

Jossen, Valentin, Regine Eibl-Schindler, Ralf Pörtner, Matthias Kraume, and Dieter Eibl. 2017. “Stirred Bioreactors : Current State and Developments, with Special Emphasis on Biopharmaceutical Production Processes.” In Current Developments in Biotechnology and Bioengineering, 179–215. Elsevier. https://doi.org/10.1016/B978-0-444-63663-8.00007-0.

Jossen, Valentin, et al. “Stirred Bioreactors : Current State and Developments, with Special Emphasis on Biopharmaceutical Production Processes.” Current Developments in Biotechnology and Bioengineering, Elsevier, 2017, pp. 179–215, https://doi.org/10.1016/B978-0-444-63663-8.00007-0.