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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Neural correlates of subjective arousal and valence in health and panic disorder
Authors: Wade-Bohleber, Laura Maria
Thoma, R.
Gerber, A.J.
et. al: No
DOI: 10.1016/j.pscychresns.2020.111186
Published in: Psychiatry Research: Neuroimaging
Volume(Issue): 305
Issue: 111186
Issue Date: 10-Sep-2020
Publisher / Ed. Institution: Elsevier
ISSN: 0925-4927
Language: English
Subjects: Affective faces; Circumplex model of affect; Functional magnetic resonance imaging; Panic disorder
Subject (DDC): 616.8: Neurology, diseases of nervous system
Abstract: Aberrant emotion processing is a core characteristic of panic disorder (PD). Findings concerning the underlying neural pathways remain inconsistent. We applied functional magnetic resonance imaging (fMRI) in the context of a task based on the circumplex model of affect. This model links affective states to two underlying neurophysiological systems: arousal and valence. Twenty-two healthy participants and 20 participants with PD rated arousal and valence in response to affective faces during fMRI. In healthy controls, we found that arousal modulated the hemodynamic response in the parahippocampus, the ventromedial prefrontal cortex and the cuneus during face perception. Valence and extreme ratings of valence modulated the hemodynamic response in temporal, parietal, somatosensory, premotor and cerebellar regions. Comparing healthy controls to participants with PD, we found that healthy controls showed a stronger modulation of the hemodynamic response during face perception associated with extreme ratings of valence in the parahippocampus and the supplementary motor area. This suggests parahippocampal dysfunction in the processing of highly valenced affective faces in PD, which may underlie aberrant contextualization of strong affective stimuli. Our findings need to be interpreted with care as they were adjusted for multiple comparisons using a liberal correction procedure.
Fulltext version: Published version
License (according to publishing contract): CC BY-NC-ND 4.0: Attribution - Non commercial - No derivatives 4.0 International
Departement: Applied Psychology
Organisational Unit: Psychological Institute (PI)
Appears in collections:Publikationen Angewandte Psychologie

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