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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-20637
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dc.contributor.authorFitzli, Dora-
dc.contributor.authorStoeckli, Esther T.-
dc.contributor.authorKunz, Stefan-
dc.contributor.authorSiribour, Kingsley-
dc.contributor.authorRader, Christoph-
dc.contributor.authorKunz, Beat-
dc.contributor.authorKozlov, Serguei V.-
dc.contributor.authorBuchstaller, Andrea-
dc.contributor.authorLane, Robert P.-
dc.contributor.authorSuter, Daniel M.-
dc.contributor.authorDreyer, William J.-
dc.contributor.authorSonderegger, Peter-
dc.date.accessioned2020-10-15T12:51:11Z-
dc.date.available2020-10-15T12:51:11Z-
dc.date.issued2000-05-15-
dc.identifier.issn0021-9525de_CH
dc.identifier.issn1540-8140de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/20637-
dc.description.abstractAn interaction of growth cone axonin-1 with the floor-plate NgCAM-related cell adhesion molecule (NrCAM) was shown to play a crucial role in commissural axon guidance across the midline of the spinal cord. We now provide evidence that axonin-1 mediates a guidance signal without promoting axon elongation. In an in vitro assay, commissural axons grew preferentially on stripes coated with a mixture of NrCAM and NgCAM. This preference was abolished in the presence of anti-axonin-1 antibodies without a decrease in neurite length. Consistent with these findings, commissural axons in vivo only fail to extend along the longitudinal axis when both NrCAM and NgCAM interactions, but not when axonin-1 and NrCAM or axonin-1 and NgCAM interactions, are perturbed. Thus, we conclude that axonin-1 is involved in guidance of commissural axons without promoting their growth.de_CH
dc.language.isoende_CH
dc.publisherRockefeller University Pressde_CH
dc.relation.ispartofJournal of Cell Biologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAnimalsde_CH
dc.subjectAxonsde_CH
dc.subjectBinding sitesde_CH
dc.subjectCell adhesionde_CH
dc.subjectCell adhesion moleculesde_CH
dc.subjectChick embryode_CH
dc.subjectContactin 2de_CH
dc.subjectGrowth conesde_CH
dc.subjectMultigene familyde_CH
dc.subjectNeural pathwaysde_CH
dc.subjectProtein bindingde_CH
dc.subjectRecombinant proteinsde_CH
dc.subjectSpinal cordde_CH
dc.subjectEmbryonic inductionde_CH
dc.subject.ddc571: Physiologie und verwandte Themende_CH
dc.titleA direct interaction of Axonin-1 with Ngcam-related cell adhesion molecule (Nrcam) results in guidance, but not growth of commissural axonsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementRektorat und Ressortsde_CH
zhaw.organisationalunitGeneralsekretariatde_CH
dc.identifier.doi10.1083/jcb.149.4.951de_CH
dc.identifier.doi10.21256/zhaw-20637-
dc.identifier.pmid10811834de_CH
zhaw.funding.euNode_CH
zhaw.issue4de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.end968de_CH
zhaw.pages.start951de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume149de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Fitzli, D., Stoeckli, E. T., Kunz, S., Siribour, K., Rader, C., Kunz, B., Kozlov, S. V., Buchstaller, A., Lane, R. P., Suter, D. M., Dreyer, W. J., & Sonderegger, P. (2000). A direct interaction of Axonin-1 with Ngcam-related cell adhesion molecule (Nrcam) results in guidance, but not growth of commissural axons. Journal of Cell Biology, 149(4), 951–968. https://doi.org/10.1083/jcb.149.4.951
Fitzli, D. et al. (2000) ‘A direct interaction of Axonin-1 with Ngcam-related cell adhesion molecule (Nrcam) results in guidance, but not growth of commissural axons’, Journal of Cell Biology, 149(4), pp. 951–968. Available at: https://doi.org/10.1083/jcb.149.4.951.
D. Fitzli et al., “A direct interaction of Axonin-1 with Ngcam-related cell adhesion molecule (Nrcam) results in guidance, but not growth of commissural axons,” Journal of Cell Biology, vol. 149, no. 4, pp. 951–968, May 2000, doi: 10.1083/jcb.149.4.951.
FITZLI, Dora, Esther T. STOECKLI, Stefan KUNZ, Kingsley SIRIBOUR, Christoph RADER, Beat KUNZ, Serguei V. KOZLOV, Andrea BUCHSTALLER, Robert P. LANE, Daniel M. SUTER, William J. DREYER und Peter SONDEREGGER, 2000. A direct interaction of Axonin-1 with Ngcam-related cell adhesion molecule (Nrcam) results in guidance, but not growth of commissural axons. Journal of Cell Biology. 15 Mai 2000. Bd. 149, Nr. 4, S. 951–968. DOI 10.1083/jcb.149.4.951
Fitzli, Dora, Esther T. Stoeckli, Stefan Kunz, Kingsley Siribour, Christoph Rader, Beat Kunz, Serguei V. Kozlov, et al. 2000. “A Direct Interaction of Axonin-1 with Ngcam-Related Cell Adhesion Molecule (Nrcam) Results in Guidance, but Not Growth of Commissural Axons.” Journal of Cell Biology 149 (4): 951–68. https://doi.org/10.1083/jcb.149.4.951.
Fitzli, Dora, et al. “A Direct Interaction of Axonin-1 with Ngcam-Related Cell Adhesion Molecule (Nrcam) Results in Guidance, but Not Growth of Commissural Axons.” Journal of Cell Biology, vol. 149, no. 4, May 2000, pp. 951–68, https://doi.org/10.1083/jcb.149.4.951.


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