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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-1548
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dc.contributor.authorHirsch, Cordula-
dc.contributor.authorStriegl, Britta-
dc.contributor.authorMathes, Stephanie-
dc.contributor.authorAdlhart, Christian-
dc.contributor.authorEdelmann, Michael-
dc.contributor.authorBono, Epifania-
dc.contributor.authorGaan, Sabyasachi-
dc.contributor.authorSalmeia, Khalifah A.-
dc.contributor.authorHölting, Lise-
dc.contributor.authorKrebs, Alice-
dc.contributor.authorNyffeler, Johanna-
dc.contributor.authorPape, Regina-
dc.contributor.authorBürkle, Alexander-
dc.contributor.authorLeist, Marcel-
dc.contributor.authorWick, Peter-
dc.contributor.authorSchildknecht, Stefan-
dc.date.accessioned2018-01-16T15:40:59Z-
dc.date.available2018-01-16T15:40:59Z-
dc.date.issued2017-03-01-
dc.identifier.issn0340-5761de_CH
dc.identifier.issn1432-0738de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/2064-
dc.description.abstractHalogen-free organophosphorus flame retardants are considered as replacements for the phased-out class of polybrominated diphenyl ethers (PBDEs). However, toxicological information on new flame retardants is still limited. Based on their excellent flame retardation potential, we have selected three novel 9,10- dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) derivatives and assessed their toxicological profile using a battery of in vitro test systems in order to provide toxicological information before their large-scale production and use. PBDE-99, applied as a reference compound, exhibited distinct neuroselective cytotoxicity at concentrations ≥10 μM. 6-(2-((6-Oxidodibenzo[1,2]oxaphosphinin-6-yl)amino)ethoxydibenzo[1,2]oxaphosphinine-6-oxide) (ETA-DOPO) and 6,6′-(ethane-1,2-diylbis(oxy))bis(dibenzo[1,2]oxaphosphinine-6-oxide) (EG-DOPO) displayed adverse effects at concentrations >10 μM in test systems reflecting the properties of human central and peripheral nervous system neurons, as well as in a set of non-neuronal cell types. DOPO and its derivative 6,6′-(ethane-1,2-diylbis(azanediyl))bis(6H-dibenzo[1,2]oxaphosphine-6-oxide) (EDA-DOPO) were neither neurotoxic, nor did they exhibit an influence on neural crest cell migration, or on the integrity of human skin equivalents.The two compounds furthermore displayed no inflammatory activation potential, nor did they affect algae growth or daphnia viability at concentrations ≤400 μM. Based on the superior flame retardation properties,biophysical features suited for use in polyurethane foams, and low cytotoxicity of EDA-DOPO, our results suggest that it is a candidate for the replacement of currently applied flame retardants.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofArchives of Toxicologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectFlame retardantsde_CH
dc.subjectOrganophosphatede_CH
dc.subjectDermal absorptionde_CH
dc.subjectNeurotoxicityde_CH
dc.subjectPolybrominated diphenylsde_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.titleMultiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardantsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.publisher.placeBerlinde_CH
dc.identifier.doi10.21256/zhaw-1548-
dc.identifier.doi10.1007/s00204-016-1680-4de_CH
zhaw.funding.euNode_CH
zhaw.issue1de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end425de_CH
zhaw.pages.start407de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume91de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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Hirsch, C., Striegl, B., Mathes, S., Adlhart, C., Edelmann, M., Bono, E., Gaan, S., Salmeia, K. A., Hölting, L., Krebs, A., Nyffeler, J., Pape, R., Bürkle, A., Leist, M., Wick, P., & Schildknecht, S. (2017). Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants. Archives of Toxicology, 91(1), 407–425. https://doi.org/10.21256/zhaw-1548
Hirsch, C. et al. (2017) ‘Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants’, Archives of Toxicology, 91(1), pp. 407–425. Available at: https://doi.org/10.21256/zhaw-1548.
C. Hirsch et al., “Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants,” Archives of Toxicology, vol. 91, no. 1, pp. 407–425, Mar. 2017, doi: 10.21256/zhaw-1548.
HIRSCH, Cordula, Britta STRIEGL, Stephanie MATHES, Christian ADLHART, Michael EDELMANN, Epifania BONO, Sabyasachi GAAN, Khalifah A. SALMEIA, Lise HÖLTING, Alice KREBS, Johanna NYFFELER, Regina PAPE, Alexander BÜRKLE, Marcel LEIST, Peter WICK und Stefan SCHILDKNECHT, 2017. Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants. Archives of Toxicology. 1 März 2017. Bd. 91, Nr. 1, S. 407–425. DOI 10.21256/zhaw-1548
Hirsch, Cordula, Britta Striegl, Stephanie Mathes, Christian Adlhart, Michael Edelmann, Epifania Bono, Sabyasachi Gaan, et al. 2017. “Multiparameter Toxicity Assessment of Novel DOPO-Derived Organophosphorus Flame Retardants.” Archives of Toxicology 91 (1): 407–25. https://doi.org/10.21256/zhaw-1548.
Hirsch, Cordula, et al. “Multiparameter Toxicity Assessment of Novel DOPO-Derived Organophosphorus Flame Retardants.” Archives of Toxicology, vol. 91, no. 1, Mar. 2017, pp. 407–25, https://doi.org/10.21256/zhaw-1548.


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