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https://doi.org/10.21256/zhaw-21202| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Fitness benefits to bacteria of carrying prophages and prophage‐encoded antibiotic‐resistance genes peak in different environments |
| Authors: | Wendling, Carolin C. Refardt, Dominik Hall, Alex R. |
| et. al: | No |
| DOI: | 10.1111/evo.14153 10.21256/zhaw-21202 |
| Published in: | Evolution |
| Volume(Issue): | 75 |
| Issue: | 2 |
| Page(s): | 515 |
| Pages to: | 528 |
| Issue Date: | Feb-2021 |
| Publisher / Ed. Institution: | Wiley |
| ISSN: | 0014-3820 1558-5646 |
| Language: | English |
| Subjects: | Antibiotic resistance; Fitness; Lysogen; Mobile genetic element; Prophage; Temperate phage |
| Subject (DDC): | 579: Microbiology |
| Abstract: | Understanding the role of horizontal gene transfer (HGT) in adaptation is a key challenge in evolutionary biology. In microbes, an important mechanism of HGT is prophage acquisition (phage genomes integrated into bacterial chromosomes). Prophages can influence bacterial fitness via transfer of beneficial genes (including antibiotic-resistance genes, ARGs), protection from superinfecting phages, or switching to a lytic lifecycle which releases free phages infectious to competitors. We expect these effects to depend on environmental conditions because of, for example, environment-dependent induction of the lytic lifecycle. However, it remains unclear how costs/benefits of prophages vary across environments. Here, studying prophages with/without ARGs in Escherichia coli, we disentangled effects of prophages alone and adaptive genes they carry. In competition with prophage-free strains, benefits from prophages and ARGs peaked in different environments. Prophages were most beneficial when induction of the lytic lifecycle was common, whereas ARGs were more beneficial upon antibiotic exposure and with reduced prophage induction. Acquisition of prophage-encoded ARGs by competing strains was most common when prophage induction, and therefore free phages, were common. Thus, selection on prophages and adaptive genes they carry varies independently across environments, which is important for predicting the spread of mobile/integrating genetic elements and their role in evolution. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/21202 |
| Fulltext version: | Published version |
| License (according to publishing contract): | CC BY-NC 4.0: Attribution - Non commercial 4.0 International |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Natural Resource Sciences (IUNR) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 2021_Wendling-Refardt-Hall_Fitness-benefits-to-bacteria_EVO.pdf | 892.01 kB | Adobe PDF |  View/Open |
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Wendling, C. C., Refardt, D., & Hall, A. R. (2021). Fitness benefits to bacteria of carrying prophages and prophage‐encoded antibiotic‐resistance genes peak in different environments. Evolution, 75(2), 515–528. https://doi.org/10.1111/evo.14153
Wendling, C.C., Refardt, D. and Hall, A.R. (2021) ‘Fitness benefits to bacteria of carrying prophages and prophage‐encoded antibiotic‐resistance genes peak in different environments’, Evolution, 75(2), pp. 515–528. Available at: https://doi.org/10.1111/evo.14153.
C. C. Wendling, D. Refardt, and A. R. Hall, “Fitness benefits to bacteria of carrying prophages and prophage‐encoded antibiotic‐resistance genes peak in different environments,” Evolution, vol. 75, no. 2, pp. 515–528, Feb. 2021, doi: 10.1111/evo.14153.
WENDLING, Carolin C., Dominik REFARDT und Alex R. HALL, 2021. Fitness benefits to bacteria of carrying prophages and prophage‐encoded antibiotic‐resistance genes peak in different environments. Evolution. Februar 2021. Bd. 75, Nr. 2, S. 515–528. DOI 10.1111/evo.14153
Wendling, Carolin C., Dominik Refardt, and Alex R. Hall. 2021. “Fitness Benefits to Bacteria of Carrying Prophages and Prophage‐Encoded Antibiotic‐Resistance Genes Peak in Different Environments.” Evolution 75 (2): 515–28. https://doi.org/10.1111/evo.14153.
Wendling, Carolin C., et al. “Fitness Benefits to Bacteria of Carrying Prophages and Prophage‐Encoded Antibiotic‐Resistance Genes Peak in Different Environments.” Evolution, vol. 75, no. 2, Feb. 2021, pp. 515–28, https://doi.org/10.1111/evo.14153.
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