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  4. Publikationen Life Sciences und Facility Management
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dc.contributor.authorBakker, Mark K.-
dc.contributor.authorvan der Spek, Rick A. A.-
dc.contributor.authorvan Rheenen, Wouter-
dc.contributor.authorMorel, Sandrine-
dc.contributor.authorBourcier, Romain-
dc.contributor.authorHostettler, Isabel C.-
dc.contributor.authorAlg, Varinder S.-
dc.contributor.authorvan Eijk, Kristel R.-
dc.contributor.authorKoido, Masaru-
dc.contributor.authorAkiyama, Masato-
dc.contributor.authorTerao, Chikashi-
dc.contributor.authorMatsuda, Koichi-
dc.contributor.authorWalters, Robin G.-
dc.contributor.authorLin, Kuang-
dc.contributor.authorLi, Liming-
dc.contributor.authorMillwood, Iona Y.-
dc.contributor.authorChen, Zhengming-
dc.contributor.authorRouleau, Guy A.-
dc.contributor.authorZhou, Sirui-
dc.contributor.authorRannikmäe, Kristiina-
dc.contributor.authorSudlow, Cathie L. M.-
dc.contributor.authorHoulden, Henry-
dc.contributor.authorvan den Berg, Leonard H.-
dc.contributor.authorDina, Christian-
dc.contributor.authorNaggara, Olivier-
dc.contributor.authorGentric, Jean-Christophe-
dc.contributor.authorShotar, Eimad-
dc.contributor.authorEugène, François-
dc.contributor.authorDesal, Hubert-
dc.contributor.authorWinsvold, Bendik S.-
dc.contributor.authorBørte, Sigrid-
dc.contributor.authorJohnsen, Marianne Bakke-
dc.contributor.authorBrumpton, Ben M.-
dc.contributor.authorSandvei, Marie Søfteland-
dc.contributor.authorWiller, Cristen J.-
dc.contributor.authorHveem, Kristian-
dc.contributor.authorZwart, John-Anker-
dc.contributor.authorVerschuren, W. M. Monique-
dc.contributor.authorFriedrich, Christoph M.-
dc.contributor.authorHirsch, Sven-
dc.contributor.authorSchilling, Sabine-
dc.contributor.authorDauvillier, Jérôme-
dc.contributor.authorMartin, Olivier-
dc.contributor.authorJones, Gregory T.-
dc.contributor.authorBown, Matthew J.-
dc.contributor.authorKo, Nerissa U.-
dc.contributor.authorKim, Helen-
dc.contributor.authorColeman, Jonathan R. I.-
dc.contributor.authorBreen, Gerome-
dc.contributor.authorZaroff, Jonathan G.-
dc.contributor.authorKlijn, Catharina J. M.-
dc.contributor.authorMalik, Rainer-
dc.contributor.authorDichgans, Martin-
dc.contributor.authorSargurupremraj, Muralidharan-
dc.contributor.authorTatlisumak, Turgut-
dc.contributor.authorAmouyel, Philippe-
dc.contributor.authorDebette, Stéphanie-
dc.contributor.authorRinkel, Gabriel J. E.-
dc.contributor.authorWorrall, Bradford B.-
dc.contributor.authorPera, Joanna-
dc.contributor.authorSlowik, Agnieszka-
dc.contributor.authorGaál-Paavola, Emília I.-
dc.contributor.authorNiemelä, Mika-
dc.contributor.authorJääskeläinen, Juha E.-
dc.contributor.authorvon Und Zu Fraunberg, Mikael-
dc.contributor.authorLindgren, Antti-
dc.contributor.authorBroderick, Joseph P.-
dc.contributor.authorWerring, David J.-
dc.contributor.authorWoo, Daniel-
dc.contributor.authorRedon, Richard-
dc.contributor.authorBijlenga, Philippe-
dc.contributor.authorKamatani, Yoichiro-
dc.contributor.authorVeldink, Jan H.-
dc.contributor.authorRuigrok, Ynte M.-
dc.date.accessioned2021-02-04T10:31:53Z-
dc.date.available2021-02-04T10:31:53Z-
dc.date.issued2020-11-16-
dc.identifier.issn1061-4036de_CH
dc.identifier.issn1546-1718de_CH
dc.identifier.urihttps://europepmc.org/article/PMC/7116530de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/21534-
dc.descriptionAn author correction to this article published in December 2020 is available at https://doi.org/10.1038/s41588-020-00760-4.de_CH
dc.description.abstractRupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. We also find a suggestive role for endothelial cells by using gene mapping and heritability enrichment. Drug-target enrichment shows pleiotropy between intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial aneurysm pathophysiology. Finally, genetic risks for smoking and high blood pressure, the two main clinical risk factors, play important roles in intracranial aneurysm risk, and drive most of the genetic correlation between intracranial aneurysms and other cerebrovascular traits.de_CH
dc.language.isoende_CH
dc.publisherNature Publishing Groupde_CH
dc.relation.ispartofNature Geneticsde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectCerebrovascular disorderde_CH
dc.subjectGenome-wide association studyde_CH
dc.subjectStrokede_CH
dc.subjectIntracranial aneurysmde_CH
dc.subjectGenetic risk factorde_CH
dc.subject.ddc572: Biochemiede_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleGenome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factorsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Computational Life Sciences (ICLS)de_CH
dc.identifier.doi10.1038/s41588-020-00725-7de_CH
dc.identifier.pmid33199917de_CH
zhaw.funding.euNode_CH
zhaw.issue12de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end1313de_CH
zhaw.pages.start1303de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume52de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedBiomedical Simulationde_CH
zhaw.funding.zhawAneuXde_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Bakker, M. K., van der Spek, R. A. A., van Rheenen, W., Morel, S., Bourcier, R., Hostettler, I. C., Alg, V. S., van Eijk, K. R., Koido, M., Akiyama, M., Terao, C., Matsuda, K., Walters, R. G., Lin, K., Li, L., Millwood, I. Y., Chen, Z., Rouleau, G. A., Zhou, S., et al. (2020). Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors. Nature Genetics, 52(12), 1303–1313. https://doi.org/10.1038/s41588-020-00725-7
Bakker, M.K. et al. (2020) ‘Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors’, Nature Genetics, 52(12), pp. 1303–1313. Available at: https://doi.org/10.1038/s41588-020-00725-7.
M. K. Bakker et al., “Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors,” Nature Genetics, vol. 52, no. 12, pp. 1303–1313, Nov. 2020, doi: 10.1038/s41588-020-00725-7.
BAKKER, Mark K., Rick A. A. VAN DER SPEK, Wouter VAN RHEENEN, Sandrine MOREL, Romain BOURCIER, Isabel C. HOSTETTLER, Varinder S. ALG, Kristel R. VAN EIJK, Masaru KOIDO, Masato AKIYAMA, Chikashi TERAO, Koichi MATSUDA, Robin G. WALTERS, Kuang LIN, Liming LI, Iona Y. MILLWOOD, Zhengming CHEN, Guy A. ROULEAU, Sirui ZHOU, Kristiina RANNIKMÄE, Cathie L. M. SUDLOW, Henry HOULDEN, Leonard H. VAN DEN BERG, Christian DINA, Olivier NAGGARA, Jean-Christophe GENTRIC, Eimad SHOTAR, François EUGÈNE, Hubert DESAL, Bendik S. WINSVOLD, Sigrid BØRTE, Marianne Bakke JOHNSEN, Ben M. BRUMPTON, Marie Søfteland SANDVEI, Cristen J. WILLER, Kristian HVEEM, John-Anker ZWART, W. M. Monique VERSCHUREN, Christoph M. FRIEDRICH, Sven HIRSCH, Sabine SCHILLING, Jérôme DAUVILLIER, Olivier MARTIN, Gregory T. JONES, Matthew J. BOWN, Nerissa U. KO, Helen KIM, Jonathan R. I. COLEMAN, Gerome BREEN, Jonathan G. ZAROFF, Catharina J. M. KLIJN, Rainer MALIK, Martin DICHGANS, Muralidharan SARGURUPREMRAJ, Turgut TATLISUMAK, Philippe AMOUYEL, Stéphanie DEBETTE, Gabriel J. E. RINKEL, Bradford B. WORRALL, Joanna PERA, Agnieszka SLOWIK, Emília I. GAÁL-PAAVOLA, Mika NIEMELÄ, Juha E. JÄÄSKELÄINEN, Mikael VON UND ZU FRAUNBERG, Antti LINDGREN, Joseph P. BRODERICK, David J. WERRING, Daniel WOO, Richard REDON, Philippe BIJLENGA, Yoichiro KAMATANI, Jan H. VELDINK und Ynte M. RUIGROK, 2020. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors. Nature Genetics [online]. 16 November 2020. Bd. 52, Nr. 12, S. 1303–1313. DOI 10.1038/s41588-020-00725-7. Verfügbar unter: https://europepmc.org/article/PMC/7116530
Bakker, Mark K., Rick A. A. van der Spek, Wouter van Rheenen, Sandrine Morel, Romain Bourcier, Isabel C. Hostettler, Varinder S. Alg, et al. 2020. “Genome-Wide Association Study of Intracranial Aneurysms Identifies 17 Risk Loci and Genetic Overlap with Clinical Risk Factors.” Nature Genetics 52 (12): 1303–13. https://doi.org/10.1038/s41588-020-00725-7.
Bakker, Mark K., et al. “Genome-Wide Association Study of Intracranial Aneurysms Identifies 17 Risk Loci and Genetic Overlap with Clinical Risk Factors.” Nature Genetics, vol. 52, no. 12, Nov. 2020, pp. 1303–13, https://doi.org/10.1038/s41588-020-00725-7.


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