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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-21579
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dc.contributor.authorJuchler, Norman-
dc.contributor.authorSchilling, Sabine-
dc.contributor.authorBijlenga, Philippe-
dc.contributor.authorMorel, Sandrine-
dc.contributor.authorRüfenacht, Daniel-
dc.contributor.authorKurtcuoglu, Vartan-
dc.contributor.authorHirsch, Sven-
dc.date.accessioned2021-02-08T14:04:05Z-
dc.date.available2021-02-08T14:04:05Z-
dc.date.issued2020-06-04-
dc.identifier.issn0001-6268de_CH
dc.identifier.issn0942-0940de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/21579-
dc.descriptionErworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)de_CH
dc.description.abstractBackground: Morphological irregularity is linked to intracranial aneurysm wall instability and manifests in the lumen shape. Yet there is currently no consent on how to assess shape irregularity. The aims of this work are to quantify irregularity as perceived by clinicians, to break down irregularity into morphological attributes, and to relate these to clinically relevant factors such as rupture status, aneurysm location, and patient age or sex. Methods: Thirteen clinicians and 26 laypersons assessed 134 aneurysm lumen segmentations in terms of overall perceived irregularity and five different morphological attributes (presence/absence of a rough surface, blebs, lobules, asymmetry, complex geometry of the parent vasculature). We examined rater agreement and compared the ratings with clinical factors by means of regression analysis or binary classification. Results: Using rank-based aggregation, the irregularity ratings of clinicians and laypersons did not differ statistically. Perceived irregularity showed good agreement with curvature (coefficient of determination R2 = 0.68 ± 0.08) and was modeled very accurately using the five morphological rating attributes plus shape elongation (R2 = 0.95 ± 0.02). In agreement with previous studies, irregularity was associated with aneurysm rupture status (AUC = 0.81 ± 0.08); adding aneurysm location as an explanatory variable increased the AUC to 0.87 ± 0.09. Besides irregularity, perceived asymmetry, presence of blebs or lobules, aneurysm size, non-sphericity, and curvature were linked to rupture. No association was found between morphology and any of patient sex, age, and history of smoking or hypertension. Aneurysm size was linked to morphology. Conclusions: Irregular lumen shape carries significant information on the aneurysm’s disease status. Irregularity constitutes a continuous parameter that shows a strong association with the rupture status. To improve the objectivity of morphological assessment, we suggest examining shape through six different morphological attributes, which can characterize irregularity accurately.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofActa Neurochirurgicade_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectIntracranial aneurysmde_CH
dc.subjectIrregularityde_CH
dc.subjectQuantitative morphologyde_CH
dc.subjectRating studyde_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleShape irregularity of the intracranial aneurysm lumen exhibits diagnostic valuede_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Computational Life Sciences (ICLS)de_CH
dc.identifier.doi10.1007/s00701-020-04428-0de_CH
dc.identifier.doi10.21256/zhaw-21579-
dc.identifier.pmid32500254de_CH
zhaw.funding.euNode_CH
zhaw.issue9de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end2270de_CH
zhaw.pages.start2261de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume162de_CH
zhaw.embargo.end2025-10-01de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedBiomedical Simulationde_CH
zhaw.webfeedMedical Image Analysis & Data Modelingde_CH
zhaw.funding.zhawAneuXde_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Juchler, N., Schilling, S., Bijlenga, P., Morel, S., Rüfenacht, D., Kurtcuoglu, V., & Hirsch, S. (2020). Shape irregularity of the intracranial aneurysm lumen exhibits diagnostic value. Acta Neurochirurgica, 162(9), 2261–2270. https://doi.org/10.1007/s00701-020-04428-0
Juchler, N. et al. (2020) ‘Shape irregularity of the intracranial aneurysm lumen exhibits diagnostic value’, Acta Neurochirurgica, 162(9), pp. 2261–2270. Available at: https://doi.org/10.1007/s00701-020-04428-0.
N. Juchler et al., “Shape irregularity of the intracranial aneurysm lumen exhibits diagnostic value,” Acta Neurochirurgica, vol. 162, no. 9, pp. 2261–2270, Jun. 2020, doi: 10.1007/s00701-020-04428-0.
JUCHLER, Norman, Sabine SCHILLING, Philippe BIJLENGA, Sandrine MOREL, Daniel RÜFENACHT, Vartan KURTCUOGLU und Sven HIRSCH, 2020. Shape irregularity of the intracranial aneurysm lumen exhibits diagnostic value. Acta Neurochirurgica. 4 Juni 2020. Bd. 162, Nr. 9, S. 2261–2270. DOI 10.1007/s00701-020-04428-0
Juchler, Norman, Sabine Schilling, Philippe Bijlenga, Sandrine Morel, Daniel Rüfenacht, Vartan Kurtcuoglu, and Sven Hirsch. 2020. “Shape Irregularity of the Intracranial Aneurysm Lumen Exhibits Diagnostic Value.” Acta Neurochirurgica 162 (9): 2261–70. https://doi.org/10.1007/s00701-020-04428-0.
Juchler, Norman, et al. “Shape Irregularity of the Intracranial Aneurysm Lumen Exhibits Diagnostic Value.” Acta Neurochirurgica, vol. 162, no. 9, June 2020, pp. 2261–70, https://doi.org/10.1007/s00701-020-04428-0.


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