|Title:||Composition for treatment of pathogens that are resistant to tetracyclines|
|Patent submitter:||BioVersys AG|
|Published as:||EP2762134A1; EP2950793B1; US2015359791A1; US9682079B2; WO2014118361A1|
|Abstract:||The invention relates to compounds and pharmaceutical compositions useful in combination with tetracyclines in the treatment of bacterial infections caused by Gram- positive and Gram-negative pathogens, with particular efficacy in tetracycline resistant strains. These compounds specifically bind to TetR and therefore prevent the transcriptional activation of tet resistance genes. The compounds have a potentiating effect on the activity of members of the tetracycline family, in particular of tetracycline, minocycline, doxycycline and tigecycline, in the treatment of tetracycline susceptible, intermediate and tetracycline resistant pathogens.|
|Departement:||Life Sciences and Facility Management|
|Organisational Unit:||Institute of Chemistry and Biotechnology (ICBT)|
|Appears in collections:||Patente Life Sciences und Facility Management|
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