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dc.contributor.authorNeidhart, Berna-
dc.contributor.authorKowalska, Malwina-
dc.contributor.authorValentin, Jules D. P.-
dc.contributor.authorGall, Flavio-
dc.contributor.authorRen, Qun-
dc.contributor.authorRiedl, Rainer-
dc.contributor.authorPot, Simon-
dc.contributor.authorRottmar, Markus-
dc.date.accessioned2021-02-18T13:47:49Z-
dc.date.available2021-02-18T13:47:49Z-
dc.date.issued2021-
dc.identifier.issn1525-7797de_CH
dc.identifier.issn1526-4602de_CH
dc.identifier.urihttps://www.dora.lib4ri.ch/empa/islandora/object/empa:24355de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/21814-
dc.description.abstractMatrix metalloproteinase 9 (MMP-9) has a key role in many biological processes, and while it is crucial for a normal immune response, excessive release of this enzyme can lead to severe tissue damage, as evidenced by proteolytic digestion and perforation of the cornea during infectious keratitis. Current medical management strategies for keratitis mostly focus on antibacterial effects, but largely neglect the role of excess MMP activity. Here, a cyclic tissue inhibitor of metalloproteinase (TIMP) peptidomimetic, which downregulated MMP-9 expression both at the mRNA and protein levels as well as MMP-9 activity in THP-1-derived macrophages, is reported. A similar downregulating effect could also be observed on α smooth muscle actin (α-SMA) expression in fibroblasts. Furthermore, the TIMP peptidomimetic reduced Pseudomonas aeruginosa-induced MMP-9 activity in an ex vivo porcine infectious keratitis model and histological examinations demonstrated that a decrease of corneal thickness, associated with keratitis progression, was inhibited upon peptidomimetic treatment. The presented approach to reduce MMP-9 activity thus holds great potential to decrease corneal tissue damage and improve the clinical success of current treatment strategies for infectious keratitis.de_CH
dc.language.isoende_CH
dc.publisherAmerican Chemical Societyde_CH
dc.relation.ispartofBiomacromoleculesde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectImmunologyde_CH
dc.subjectInfectious diseasede_CH
dc.subjectPeptidomimeticsde_CH
dc.subjectPeptides and proteinsde_CH
dc.subjectDifferentiationde_CH
dc.subject.ddc540: Chemiede_CH
dc.titleTissue inhibitor of metalloproteinase (TIMP) peptidomimetic as an adjunctive therapy for infectious keratitisde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1021/acs.biomac.0c01473de_CH
dc.identifier.pmid33347749de_CH
zhaw.funding.euNode_CH
zhaw.issue2de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end639de_CH
zhaw.pages.start629de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume22de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedCC Drug Discoveryde_CH
zhaw.funding.zhawBurn Wound Treatmentde_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Neidhart, B., Kowalska, M., Valentin, J. D. P., Gall, F., Ren, Q., Riedl, R., Pot, S., & Rottmar, M. (2021). Tissue inhibitor of metalloproteinase (TIMP) peptidomimetic as an adjunctive therapy for infectious keratitis. Biomacromolecules, 22(2), 629–639. https://doi.org/10.1021/acs.biomac.0c01473
Neidhart, B. et al. (2021) ‘Tissue inhibitor of metalloproteinase (TIMP) peptidomimetic as an adjunctive therapy for infectious keratitis’, Biomacromolecules, 22(2), pp. 629–639. Available at: https://doi.org/10.1021/acs.biomac.0c01473.
B. Neidhart et al., “Tissue inhibitor of metalloproteinase (TIMP) peptidomimetic as an adjunctive therapy for infectious keratitis,” Biomacromolecules, vol. 22, no. 2, pp. 629–639, 2021, doi: 10.1021/acs.biomac.0c01473.
NEIDHART, Berna, Malwina KOWALSKA, Jules D. P. VALENTIN, Flavio GALL, Qun REN, Rainer RIEDL, Simon POT und Markus ROTTMAR, 2021. Tissue inhibitor of metalloproteinase (TIMP) peptidomimetic as an adjunctive therapy for infectious keratitis. Biomacromolecules [online]. 2021. Bd. 22, Nr. 2, S. 629–639. DOI 10.1021/acs.biomac.0c01473. Verfügbar unter: https://www.dora.lib4ri.ch/empa/islandora/object/empa:24355
Neidhart, Berna, Malwina Kowalska, Jules D. P. Valentin, Flavio Gall, Qun Ren, Rainer Riedl, Simon Pot, and Markus Rottmar. 2021. “Tissue Inhibitor of Metalloproteinase (TIMP) Peptidomimetic as an Adjunctive Therapy for Infectious Keratitis.” Biomacromolecules 22 (2): 629–39. https://doi.org/10.1021/acs.biomac.0c01473.
Neidhart, Berna, et al. “Tissue Inhibitor of Metalloproteinase (TIMP) Peptidomimetic as an Adjunctive Therapy for Infectious Keratitis.” Biomacromolecules, vol. 22, no. 2, 2021, pp. 629–39, https://doi.org/10.1021/acs.biomac.0c01473.


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