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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes
Authors: Schirmer, Cedric
Maschke, Rüdiger
Pörtner, Ralf
Eibl, Dieter
et. al: No
DOI: 10.1007/s00253-021-11180-7
Published in: Applied Microbiology and Biotechnology
Issue Date: 2-Mar-2021
Publisher / Ed. Institution: Springer
ISSN: 0175-7598
Language: English
Subjects: Bioreactor agitation; Magnetic coupling; Mechanical sealing; Lip seal; Hygienic requirements; Application trends
Subject (DDC): 660: Chemical engineering
Abstract: No matter the scale, stirred tank bioreactors are the most commonly used systems in biotechnological production processes. Single-use and reusable systems are supplied by several manufacturers. The type, size, and number of impellers used in these systems have a significant influence on the characteristics and designs of bioreactors. Depending on the desired application, classic shaft-driven systems, bearing-mounted drives, or stirring elements that levitate freely in the vessel may be employed. In systems with drive shafts, process hygiene requirements also affect the type of seal used. For sensitive processes with high hygienic requirements, magnetic-driven stirring systems, which have been the focus of much research in recent years, are recommended. This review provides the reader with an overview of the most common agitation and seal types implemented in stirred bioreactor systems, highlights their advantages and disadvantages, and explains their possible fields of application. Special attention is paid to the development of magnetically driven agitators, which are widely used in reusable systems and are also becoming more and more important in their single-use counterparts.
Fulltext version: Published version
License (according to publishing contract): CC BY 4.0: Attribution 4.0 International
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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