An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes

Schirmer, Cedric; Maschke, Rüdiger; Pörtner, Ralf; Eibl, Dieter

doi:10.1007/s00253-021-11180-7

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-21944

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes
Authors:	Schirmer, Cedric Maschke, Rüdiger Pörtner, Ralf Eibl, Dieter
et. al:	No
DOI:	10.1007/s00253-021-11180-7 10.21256/zhaw-21944
Published in:	Applied Microbiology and Biotechnology
Issue Date:	2-Mar-2021
Publisher / Ed. Institution:	Springer
ISSN:	0175-7598 1432-0614
Language:	English
Subjects:	Bioreactor agitation; Magnetic coupling; Mechanical sealing; Lip seal; Hygienic requirements; Application trends
Subject (DDC):	660: Chemical engineering
Abstract:	No matter the scale, stirred tank bioreactors are the most commonly used systems in biotechnological production processes. Single-use and reusable systems are supplied by several manufacturers. The type, size, and number of impellers used in these systems have a significant influence on the characteristics and designs of bioreactors. Depending on the desired application, classic shaft-driven systems, bearing-mounted drives, or stirring elements that levitate freely in the vessel may be employed. In systems with drive shafts, process hygiene requirements also affect the type of seal used. For sensitive processes with high hygienic requirements, magnetic-driven stirring systems, which have been the focus of much research in recent years, are recommended. This review provides the reader with an overview of the most common agitation and seal types implemented in stirred bioreactor systems, highlights their advantages and disadvantages, and explains their possible fields of application. Special attention is paid to the development of magnetically driven agitators, which are widely used in reusable systems and are also becoming more and more important in their single-use counterparts.
URI:	https://digitalcollection.zhaw.ch/handle/11475/21944
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Schirmer, C., Maschke, R., Pörtner, R., & Eibl, D. (2021). An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-021-11180-7

Schirmer, C. et al. (2021) ‘An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes’, Applied Microbiology and Biotechnology [Preprint]. Available at: https://doi.org/10.1007/s00253-021-11180-7.

C. Schirmer, R. Maschke, R. Pörtner, and D. Eibl, “An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes,” Applied Microbiology and Biotechnology, Mar. 2021, doi: 10.1007/s00253-021-11180-7.

SCHIRMER, Cedric, Rüdiger MASCHKE, Ralf PÖRTNER und Dieter EIBL, 2021. An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes. Applied Microbiology and Biotechnology. 2 März 2021. DOI 10.1007/s00253-021-11180-7

Schirmer, Cedric, Rüdiger Maschke, Ralf Pörtner, and Dieter Eibl. 2021. “An Overview of Drive Systems and Sealing Types in Stirred Bioreactors Used in Biotechnological Processes.” Applied Microbiology and Biotechnology, March. https://doi.org/10.1007/s00253-021-11180-7.

Schirmer, Cedric, et al. “An Overview of Drive Systems and Sealing Types in Stirred Bioreactors Used in Biotechnological Processes.” Applied Microbiology and Biotechnology, Mar. 2021, https://doi.org/10.1007/s00253-021-11180-7.