Single‐use bioreactors : an overview

Jossen, Valentin; Eibl-Schindler, Regine; Eibl, Dieter

doi:10.1002/9781119477891.ch4

Publication type:	Book part
Type of review:	Not specified
Title:	Single‐use bioreactors : an overview
Authors:	Jossen, Valentin Eibl-Schindler, Regine Eibl, Dieter
et. al:	No
DOI:	10.1002/9781119477891.ch4
Published in:	Single‐Use Technology in Biopharmaceutical Manufacture
Page(s):	37
Pages to:	52
Issue Date:	2019
Publisher / Ed. Institution:	Wiley
ISBN:	9781119477839 9781119477891
Language:	English
Subject (DDC):	660: Chemical engineering
Abstract:	This chapter aims to give an overview of instrumented single‐use bioreactor (SUB) types that are currently available commercially. Based on the milestones in the development of SUBs, it focuses on the three most often applied types: wave‐mixed, stirred, and orbitally shaken versions. Their typical working principles are explained, possible fields of application are deduced, and trends in their selection are summarized. The development of SUBs can be described in three phases: the early beginnings; the establishment of disposable membrane bioreactors, multitray cell culture systems, and the first bag bioreactors; and the expansion of wave‐mixed, stirred, orbitally shaken, and further SUBs. The most suitable bioreactor for a desired application depends on several factors. The selection of the bioreactor is significantly influenced by the cultivation task, the engineering parameters of the bioreactor, the scale, the production organism, the legal requirements, the infrastructure, the know‐how of staff, and the costs for investment and operation.
URI:	https://digitalcollection.zhaw.ch/handle/11475/21976
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Jossen, V., Eibl-Schindler, R., & Eibl, D. (2019). Single‐use bioreactors : an overview. In Single‐Use Technology in Biopharmaceutical Manufacture (pp. 37–52). Wiley. https://doi.org/10.1002/9781119477891.ch4

Jossen, V., Eibl-Schindler, R. and Eibl, D. (2019) ‘Single‐use bioreactors : an overview’, in Single‐Use Technology in Biopharmaceutical Manufacture. Wiley, pp. 37–52. Available at: https://doi.org/10.1002/9781119477891.ch4.

V. Jossen, R. Eibl-Schindler, and D. Eibl, “Single‐use bioreactors : an overview,” in Single‐Use Technology in Biopharmaceutical Manufacture, Wiley, 2019, pp. 37–52. doi: 10.1002/9781119477891.ch4.

JOSSEN, Valentin, Regine EIBL-SCHINDLER und Dieter EIBL, 2019. Single‐use bioreactors : an overview. In: Single‐Use Technology in Biopharmaceutical Manufacture. Wiley. S. 37–52. ISBN 9781119477839

Jossen, Valentin, Regine Eibl-Schindler, and Dieter Eibl. 2019. “Single‐Use Bioreactors : An Overview.” In Single‐Use Technology in Biopharmaceutical Manufacture, 37–52. Wiley. https://doi.org/10.1002/9781119477891.ch4.

Jossen, Valentin, et al. “Single‐Use Bioreactors : An Overview.” Single‐Use Technology in Biopharmaceutical Manufacture, Wiley, 2019, pp. 37–52, https://doi.org/10.1002/9781119477891.ch4.