Negative affect is unrelated to fluctuations in hormone levels across the menstrual cycle : evidence from a multisite observational study across two successive cycles

Hengartner, Michael Pascal; Kruger, Tillmann H. C.; Geraedts, Kirsten; Tronci, Enrico; Mancini, Toni; Ille, Fabian; Egli, Marcel; Röblitz, Susanna; Ehrig, Rainald; Saleh, Lanja; Spanaus, Katharina; Schippert, Cordula; Zhang, Yuanyuan; Leeners, Brigitte

doi:10.1016/j.jpsychores.2017.05.018

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Negative affect is unrelated to fluctuations in hormone levels across the menstrual cycle : evidence from a multisite observational study across two successive cycles
Authors:	Hengartner, Michael Pascal Kruger, Tillmann H. C. Geraedts, Kirsten Tronci, Enrico Mancini, Toni Ille, Fabian Egli, Marcel Röblitz, Susanna Ehrig, Rainald Saleh, Lanja Spanaus, Katharina Schippert, Cordula Zhang, Yuanyuan Leeners, Brigitte
DOI:	10.1016/j.jpsychores.2017.05.018
Published in:	Journal of Psychosomatic Research
Volume(Issue):	99
Page(s):	21
Pages to:	27
Issue Date:	2017
Publisher / Ed. Institution:	Elsevier
ISSN:	0022-3999 1879-1360
Language:	English
Subject (DDC):	610: Medicine and health
Abstract:	Background: Female sex hormones may play a crucial role in the occurrence of cycle-related mood disorders. However, the literature is inconsistent and methodologically stringent observational studies on the relationship between sex hormones and negative affect are lacking. Methods: In this longitudinal multisite study from Hannover, Germany, and Zurich, Switzerland, we examined oestrogen, progesterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone serum levels in association with negative affect as measured with the Positive and Negative Affect Schedule (PANAS). Negative affect and hormone assays were collected at four consecutive time points comprising menstrual, pre-ovulatory, mid-luteal and premenstrual phase across two cycles (n = 87 and n = 67 for the first and second cycles). The Beck Depression Inventory (BDI) was assessed once prior to the first cycle and included as a secondary measure. Results: Mean negative affect scores did not significantly fluctuate across both cycles and there was in particular no symptom increase premenstrually. No sex hormone consistently related to repeated measures of negative affect across two consecutive cycles. The BDI sum-score assessed at baseline was not related to hormone levels across the first cycle. Conclusions: This is the first multisite longitudinal study on the association between negative affect and sex hormone levels encompassing two consecutive menstrual cycles. Negative affect did not fluctuate across the cycle and there was no direct and uniform association between sex hormones and self-reported negative affect. These findings suggest that moderators such as personality traits and epigenetics should be considered in future research.
URI:	https://digitalcollection.zhaw.ch/handle/11475/2231
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Applied Psychology
Organisational Unit:	Psychological Institute (PI)
Appears in collections:	Publikationen Angewandte Psychologie

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Hengartner, M. P., Kruger, T. H. C., Geraedts, K., Tronci, E., Mancini, T., Ille, F., Egli, M., Röblitz, S., Ehrig, R., Saleh, L., Spanaus, K., Schippert, C., Zhang, Y., & Leeners, B. (2017). Negative affect is unrelated to fluctuations in hormone levels across the menstrual cycle : evidence from a multisite observational study across two successive cycles. Journal of Psychosomatic Research, 99, 21–27. https://doi.org/10.1016/j.jpsychores.2017.05.018

Hengartner, M.P. et al. (2017) ‘Negative affect is unrelated to fluctuations in hormone levels across the menstrual cycle : evidence from a multisite observational study across two successive cycles’, Journal of Psychosomatic Research, 99, pp. 21–27. Available at: https://doi.org/10.1016/j.jpsychores.2017.05.018.

M. P. Hengartner et al., “Negative affect is unrelated to fluctuations in hormone levels across the menstrual cycle : evidence from a multisite observational study across two successive cycles,” Journal of Psychosomatic Research, vol. 99, pp. 21–27, 2017, doi: 10.1016/j.jpsychores.2017.05.018.

HENGARTNER, Michael Pascal, Tillmann H. C. KRUGER, Kirsten GERAEDTS, Enrico TRONCI, Toni MANCINI, Fabian ILLE, Marcel EGLI, Susanna RÖBLITZ, Rainald EHRIG, Lanja SALEH, Katharina SPANAUS, Cordula SCHIPPERT, Yuanyuan ZHANG und Brigitte LEENERS, 2017. Negative affect is unrelated to fluctuations in hormone levels across the menstrual cycle : evidence from a multisite observational study across two successive cycles. Journal of Psychosomatic Research. 2017. Bd. 99, S. 21–27. DOI 10.1016/j.jpsychores.2017.05.018

Hengartner, Michael Pascal, Tillmann H. C. Kruger, Kirsten Geraedts, Enrico Tronci, Toni Mancini, Fabian Ille, Marcel Egli, et al. 2017. “Negative Affect Is Unrelated to Fluctuations in Hormone Levels across the Menstrual Cycle : Evidence from a Multisite Observational Study across Two Successive Cycles.” Journal of Psychosomatic Research 99: 21–27. https://doi.org/10.1016/j.jpsychores.2017.05.018.

Hengartner, Michael Pascal, et al. “Negative Affect Is Unrelated to Fluctuations in Hormone Levels across the Menstrual Cycle : Evidence from a Multisite Observational Study across Two Successive Cycles.” Journal of Psychosomatic Research, vol. 99, 2017, pp. 21–27, https://doi.org/10.1016/j.jpsychores.2017.05.018.