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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-1581
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dc.contributor.authorEibl-Schindler, Regine-
dc.contributor.authorKaiser, Stephan-
dc.contributor.authorLombriser, Renate-
dc.contributor.authorEibl, Dieter-
dc.date.accessioned2018-01-29T15:00:39Z-
dc.date.available2018-01-29T15:00:39Z-
dc.date.issued2010-03-
dc.identifier.issn0175-7598de_CH
dc.identifier.issn1432-0614de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/2246-
dc.descriptionErworben im Rahmen der Schweizer Nationallizenz (http://www.nationallizenzen.ch)de_CH
dc.description.abstractDisposable bioreactors have increasingly been incorporated into preclinical, clinical, and production-scale biotechnological facilities over the last few years. Driven by market needs, and, in particular, by the developers and manufacturers of drugs, vaccines, and further biologicals, there has been a trend toward the use of disposable seed bioreactors as well as production bioreactors. Numerous studies documenting their advantages in use have contributed to further new developments and have resulted in the availability of a multitude of disposable bioreactor types which differ in power input, design, instrumentation, and scale of the cultivation container. In this review, the term “disposable bioreactor” is defined, the benefits and constraints of disposable bioreactors are discussed, and critical phases and milestones in the development of disposable bioreactors are summarized. An overview of the disposable bioreactors that are currently commercially available is provided, and the domination of wave-mixed, orbitally shaken, and, in particular, stirred disposable bioreactors in animal cell-derived productions at cubic meter scale is reported. The growth of this type of reactor system is attributed to the recent availability of stirred disposable benchtop systems such as the Mobius CellReady 3 L Bioreactor. Analysis of the data from computational fluid dynamic simulation studies and first cultivation runs confirms that this novel bioreactor system is a viable alternative to traditional cell culture bioreactors at benchtop scale.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofApplied Microbiology and Biotechnologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectBiomanufacturingde_CH
dc.subjectBioreactor typesde_CH
dc.subjectCell culturesde_CH
dc.subjectCFDde_CH
dc.subjectDisposable bioreactorde_CH
dc.subjectMicroorganismsde_CH
dc.subjectMobius CellReady 3 L bioreactorde_CH
dc.subject.ddc660: Technische Chemiede_CH
dc.titleDisposabe bioreactors : the current state-of-the-art and recommended applications in biotechnologyde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.publisher.placeBerlinde_CH
dc.identifier.doi10.21256/zhaw-1581-
dc.identifier.doi10.1007/s00253-009-2422-9de_CH
zhaw.funding.euNode_CH
zhaw.issue1de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end49de_CH
zhaw.pages.start41de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume86de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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Eibl-Schindler, R., Kaiser, S., Lombriser, R., & Eibl, D. (2010). Disposabe bioreactors : the current state-of-the-art and recommended applications in biotechnology. Applied Microbiology and Biotechnology, 86(1), 41–49. https://doi.org/10.21256/zhaw-1581
Eibl-Schindler, R. et al. (2010) ‘Disposabe bioreactors : the current state-of-the-art and recommended applications in biotechnology’, Applied Microbiology and Biotechnology, 86(1), pp. 41–49. Available at: https://doi.org/10.21256/zhaw-1581.
R. Eibl-Schindler, S. Kaiser, R. Lombriser, and D. Eibl, “Disposabe bioreactors : the current state-of-the-art and recommended applications in biotechnology,” Applied Microbiology and Biotechnology, vol. 86, no. 1, pp. 41–49, Mar. 2010, doi: 10.21256/zhaw-1581.
EIBL-SCHINDLER, Regine, Stephan KAISER, Renate LOMBRISER und Dieter EIBL, 2010. Disposabe bioreactors : the current state-of-the-art and recommended applications in biotechnology. Applied Microbiology and Biotechnology. März 2010. Bd. 86, Nr. 1, S. 41–49. DOI 10.21256/zhaw-1581
Eibl-Schindler, Regine, Stephan Kaiser, Renate Lombriser, and Dieter Eibl. 2010. “Disposabe Bioreactors : The Current State-of-the-Art and Recommended Applications in Biotechnology.” Applied Microbiology and Biotechnology 86 (1): 41–49. https://doi.org/10.21256/zhaw-1581.
Eibl-Schindler, Regine, et al. “Disposabe Bioreactors : The Current State-of-the-Art and Recommended Applications in Biotechnology.” Applied Microbiology and Biotechnology, vol. 86, no. 1, Mar. 2010, pp. 41–49, https://doi.org/10.21256/zhaw-1581.


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