Innovative, non-stirred bioreactors in scales form milliliters up to 1000 L for suspension cultures of cells using disposable bags and containers - a Swiss contribution

Werner, Sören; Eibl-Schindler, Regine; Lettenbauer, Christine; Röll, Marcel; Eibl, Dieter; De Jesus, Maria; Zhang, Xiaowei; Stettler, Matthieu; Tissot, Stephanie; Bürkie, Cedric; Broccard, Gilles; Kühner, Markus; Tanner, Rolf; Baldi, Lucia; Hacker, David; Wurm, Florian M.

doi:10.2533/chimia.2010.819

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Innovative, non-stirred bioreactors in scales form milliliters up to 1000 L for suspension cultures of cells using disposable bags and containers - a Swiss contribution
Authors:	Werner, Sören Eibl-Schindler, Regine Lettenbauer, Christine Röll, Marcel Eibl, Dieter De Jesus, Maria Zhang, Xiaowei Stettler, Matthieu Tissot, Stephanie Bürkie, Cedric Broccard, Gilles Kühner, Markus Tanner, Rolf Baldi, Lucia Hacker, David Wurm, Florian M.
DOI:	10.2533/chimia.2010.819
Published in:	Chimia
Volume(Issue):	64
Issue:	11
Page(s):	819
Pages to:	823
Issue Date:	Nov-2010
Publisher / Ed. Institution:	Schweizerische Chemische Gesellschaft
Publisher / Ed. Institution:	Bern
ISSN:	0009-4293
Language:	English
Subjects:	Disposable bioreactors; Engineering characteristics; High density cho cultures; Orbitally shaken; Wave mixed
Subject (DDC):	660: Chemical engineering
Abstract:	Innovative mixing principles in bioreactors, for example using the rocking of a platform to induce a backwards and forwards 'wave', or using orbital shaking to generate a 'wave' that runs round in a cylindrical container, have proved to be successful for the suspension cultures of cells, especially when combined with disposable materials. This article presents an overview of the engineering characteristics when these new principles are applied in bioreactors, and case studies covering scales of operation from milliliters to 1000 Liters.
URI:	https://digitalcollection.zhaw.ch/handle/11475/2251
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Werner, S., Eibl-Schindler, R., Lettenbauer, C., Röll, M., Eibl, D., De Jesus, M., Zhang, X., Stettler, M., Tissot, S., Bürkie, C., Broccard, G., Kühner, M., Tanner, R., Baldi, L., Hacker, D., & Wurm, F. M. (2010). Innovative, non-stirred bioreactors in scales form milliliters up to 1000 L for suspension cultures of cells using disposable bags and containers - a Swiss contribution. Chimia, 64(11), 819–823. https://doi.org/10.2533/chimia.2010.819

Werner, S. et al. (2010) ‘Innovative, non-stirred bioreactors in scales form milliliters up to 1000 L for suspension cultures of cells using disposable bags and containers - a Swiss contribution’, Chimia, 64(11), pp. 819–823. Available at: https://doi.org/10.2533/chimia.2010.819.

S. Werner et al., “Innovative, non-stirred bioreactors in scales form milliliters up to 1000 L for suspension cultures of cells using disposable bags and containers - a Swiss contribution,” Chimia, vol. 64, no. 11, pp. 819–823, Nov. 2010, doi: 10.2533/chimia.2010.819.

WERNER, Sören, Regine EIBL-SCHINDLER, Christine LETTENBAUER, Marcel RÖLL, Dieter EIBL, Maria DE JESUS, Xiaowei ZHANG, Matthieu STETTLER, Stephanie TISSOT, Cedric BÜRKIE, Gilles BROCCARD, Markus KÜHNER, Rolf TANNER, Lucia BALDI, David HACKER und Florian M. WURM, 2010. Innovative, non-stirred bioreactors in scales form milliliters up to 1000 L for suspension cultures of cells using disposable bags and containers - a Swiss contribution. Chimia. November 2010. Bd. 64, Nr. 11, S. 819–823. DOI 10.2533/chimia.2010.819

Werner, Sören, Regine Eibl-Schindler, Christine Lettenbauer, Marcel Röll, Dieter Eibl, Maria De Jesus, Xiaowei Zhang, et al. 2010. “Innovative, Non-Stirred Bioreactors in Scales Form Milliliters up to 1000 L for Suspension Cultures of Cells Using Disposable Bags and Containers - a Swiss Contribution.” Chimia 64 (11): 819–23. https://doi.org/10.2533/chimia.2010.819.

Werner, Sören, et al. “Innovative, Non-Stirred Bioreactors in Scales Form Milliliters up to 1000 L for Suspension Cultures of Cells Using Disposable Bags and Containers - a Swiss Contribution.” Chimia, vol. 64, no. 11, Nov. 2010, pp. 819–23, https://doi.org/10.2533/chimia.2010.819.